Metabolic regulation in the immune response to cancer

It is apparent that development of consistently effective methods of immunotherapy must await a more thorough understanding of the immune response to cancer. However, even those forms of immunotherapy which have been developed to date indicate a tremendous potential. It appears that immunotherapy may be most useful as an adjuvant to established forms of treatment. Surgery, radiation therapy and/or chemotherapy are used to remove all of the gross tumor, with immune therapy then employed to destroy the small foci of tumor which remain. As methods are developed which are effective in counteracting the immunosuppression of tumors, other means of immunotherapy may be found which are capable of destroying tumor cells while not affecting the adjacent normal tissue. Thus, the future of immune therapy holds great promise. As more is learned about the immune response to cancer, advances in therapy will certainly follow.

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Comparison by leukocyte adherence inhibition of human immune response to cancer-associated immunogens, Thomsen-Friedenreich (T) and Tn, myelin basic protein, and organ-specific cancer neoantigens

Clinical Immunology and Immunopathology ◽

10.1016/0090-1229(88)90113-4 ◽

1988 ◽

Vol 49 (2) ◽

pp. 231-241 ◽

Cited By ~ 3

Author(s):

D.M.P. Thomson ◽

Georg F. Springer ◽

Parimal R. Desai ◽

Rosemarie Scanzano ◽

Monica Gubersky ◽

...

Keyword(s):

Immune Response ◽

Basic Protein ◽

Leukocyte Adherence ◽

Specific Cancer ◽

Leukocyte Adherence Inhibition ◽

Organ Specific ◽

Immune Response To Cancer ◽

Human Immune Response ◽

Human Immune ◽

Adherence Inhibition

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LETTER TO THE EDITOR: Interaction of Allergic Disease and (Immune) Response to Cancer in Patient with Stage-4 Adenocarcinoma of the Lung

Clinical Laboratory ◽

10.7754/clin.lab.2012.120321 ◽

2013 ◽

Vol 59 (01+02/2013) ◽

Author(s):

Arzu Didem Yalcin ◽

Aysegul Kargi ◽

Burhan Savas ◽

Reginald M. Gorczynski

Keyword(s):

Immune Response ◽

Allergic Disease ◽

Adenocarcinoma Of The Lung ◽

Letter To The Editor ◽

Stage 4 ◽

Immune Response To Cancer

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Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response

Journal of Immunology Research ◽

10.1155/2018/2835761 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 10

Author(s):

Hong Zhong ◽

Minjuan Ma ◽

Tingming Liang ◽

Li Guo

Keyword(s):

Immune Response ◽

Immune System ◽

Metabolic Disorder ◽

Metabolic Regulation ◽

Public Health Issue ◽

Metabolic Dysfunction ◽

Global Public Health ◽

Adaptive Responses ◽

Living Organisms

In all living organisms, metabolic homeostasis and the immune system are the most fundamental requirements for survival. Recently, obesity has become a global public health issue, which is the cardinal risk factor for metabolic disorder. Many diseases emanating from obesity-induced metabolic dysfunction are responsible for the activated immune system, including innate and adaptive responses. Of note, inflammation is the manifest accountant signal. Deeply studied microRNAs (miRNAs) have participated in many pathways involved in metabolism and immune responses to protect cells from multiple harmful stimulants, and they play an important role in determining the progress through targeting different inflammatory pathways. Thus, immune response and metabolic regulation are highly integrated with miRNAs. Collectively, miRNAs are the new targets for therapy in immune dysfunction.

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