Incidence, risk factors, and outcomes of central venous catheter-related thromboembolism in breast cancer patients: the CAVECCAS study

Abstract Purpose: Limited risk assessment tool to stratify the risk of PICC-related thrombosis (PICC-RVT) in breast cancer patients. This study developed a model to assess the risk of PICC-RVT in breast cancer patients. Methods: We conducted a retrospective cohort study of 1284 breast cancer patients receiving PICC insertion during 1 January 2015 - 31 August 2019 at a cancer specialized hospital in Hunan province, China. The entire population is divided into two groups at a ratio of 3:1 which included a derivation sample (n=978), and a validation sample (n=284). PICC-RVT was confirmed by ultrasonography in the presence of clinical symptoms and signs. Results: PICC-RVT occurred in 40 (4.09%) of the derivation sample patients. Multivariable analysis identified 9 variables: chronic obstructive pulmonary disease, prior central venous catheter placement, higher level of Platelets, higher level of D-dimer, lower level of Activated partial thromboplastin time, menopause, no prior breast surgery, upper extremity lymphedema, and endocrine therapy. Points were assigned to each variable according to regression coefficient. The model had an area under the receiver operating characteristics curve (AUC) of 0.850 (95% CI 0.776 to 0.924), The Hosmer-Lemeshow goodness of fit was 4.781 (p=0.572). At a cutoff value of 3.5, the sensitivity and specifcity were 75% and 83%, respectively.Conclusion: Several disease-specific factors of breast cancer (e.g., menopause, endocrine therapy and upper extremity lymphedema) play important roles in the development of PICC-RVT. Patients at higher PICC-RVT risk could be candidates for close post-insertion monitoring and interventions to prevent PICC-RVT.

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Central venous catheter—related blood stream infections: incidence, risk factors, outcome, and associated pathogens

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1053/j.jvca.2004.03.009 ◽

2004 ◽

Vol 18 (3) ◽

pp. 304-308 ◽

Cited By ~ 43

Author(s):

Mandakini Pawar ◽

Yatin Mehta ◽

Pawan Kapoor ◽

Jitendra Sharma ◽

Abhinav Gupta ◽

...

Keyword(s):

Risk Factors ◽

Central Venous Catheter ◽

Venous Catheter ◽

Blood Stream ◽

Central Venous ◽

Blood Stream Infections ◽

Incidence Risk

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Upper limb lymphedema related to breast cancer therapy: incidence, risk factors, diagnostic techniques, risk reduction and optimal management

International Surgery Journal ◽

10.18203/2349-2902.isj20184636 ◽

2018 ◽

Vol 5 (11) ◽

pp. 3633

Author(s):

Hatem A. Saleh ◽

Tarek M. Rageh ◽

Suzan A. Alhassanin ◽

Mohamed A. Megahed

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Cancer Patients ◽

Upper Limb ◽

Diagnostic Techniques ◽

Breast Cancer Patients ◽

Breast Cancer Therapy ◽

Cancer Management ◽

Breast Cancer Management ◽

Incidence Risk

Background: Lymphedema remains to be a great source of morbidity for breast cancer survivors. The aim of this work is to study upper limb lymphedema following breast cancer therapy for breast cancer patients regarding its incidence, risk factors, diagnostic techniques, risk reduction and optimal management.Methods: This prospective study was done on two hundred breast cancer patients who underwent breast cancer management. The study was done in the period between May 2016 and July 2018. Exclusion criteria were Male patients, Female patients with metastatic breast cancer and who already had upper limb lymphedema before breast cancer management. All patients underwent follow up for incidence, risk factors, diagnostic techniques and management of lymphedema. Statistical analysis used: The collected data were organized, tabulated and statistically analyzed using SPSS softwareResults: The incidence of lymphedema was (18 %) distributed as follow: grade I = 55.6%, grade II = 33.3%, grade III = 11.1 % and grade IV = 0 %. The most relevant risk factors for development of lymphedema were: age between 41 and 50 years and diabetes mellitus. Higher incidence of pain (66.7%) and restricted motion (61.1%) were observed in lymphedema cases.Conclusions: Old (41:50 years) and diabetic patients are at the highest risk for developing lymphedema. Breast cancer patients of stage IIIB who had undergone modified radical mastectomy or who developed postoperative seroma are at higher risk for developing lymphedema. Physical exercises and compression garment are important part of treatment plan.

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Incidence of Central Venous Catheter-Related Infection and Risk Factors in Critically Ill Post-Operative Cancer Patients: A Randomized Prospective Cohort Study

Archives of Critical Care Medicine ◽

10.17795/accm-7732 ◽

2015 ◽

Vol 1 (4) ◽

Author(s):

Mohammad Taghi Beigmohammadi

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Central Venous Catheter ◽

Cancer Patients ◽

Critically Ill ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Venous Catheter ◽

Central Venous ◽

Catheter Related Infection

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Subclavian central venous catheter-related thrombosis in trauma patients: incidence, risk factors and influence of polyurethane type

Critical Care ◽

10.1186/cc12748 ◽

2013 ◽

Vol 17 (3) ◽

pp. R103 ◽

Cited By ~ 9

Author(s):

Ariane Gentile ◽

Laurent Petit ◽

Françoise Masson ◽

Vincent Cottenceau ◽

Josseline Bertrand-Barat ◽

...

Keyword(s):

Risk Factors ◽

Central Venous Catheter ◽

Venous Catheter ◽

Trauma Patients ◽

Central Venous ◽

Incidence Risk ◽

Catheter Related Thrombosis

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Chemotherapy-Related Amenorrhea and Menopause in Young Chinese Breast Cancer Patients: Analysis on Incidence, Risk Factors and Serum Hormone Profiles

PLoS ONE ◽

10.1371/journal.pone.0140842 ◽

2015 ◽

Vol 10 (10) ◽

pp. e0140842 ◽

Cited By ~ 13

Author(s):

Giok S. Liem ◽

Frankie K. F. Mo ◽

Elizabeth Pang ◽

Joyce J. S. Suen ◽

Nelson L. S. Tang ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Serum Hormone ◽

Incidence Risk

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Risk Factors of Thromboembolic Disease in Men with Prostate Cancer: Report from a Hispanic Population

Blood ◽

10.1182/blood-2018-99-120227 ◽

2018 ◽

Vol 132 (Supplement 1) ◽

pp. 5025-5025

Author(s):

Rodrigo Luna-Santiago ◽

Maria T Bourlon ◽

Ariel Jasqui-Bucay ◽

Alan Jasqui-Bucay ◽

Oscar Manuel Fierro-Angulo ◽

...

Keyword(s):

Prostate Cancer ◽

Risk Factors ◽

Multivariate Analysis ◽

Hip Fracture ◽

Central Venous Catheter ◽

Venous Thrombosis ◽

Cancer Patients ◽

Venous Catheter ◽

Central Venous ◽

History Of

Abstract Introduction Prostate cancer is the most frequent malignant neoplasm diagnosed in men worldwide. Patients with prostate cancer have higher rates of thrombotic events when compared with other groups of cancer patients; that can be explained because of the presence of multiple risk factors such as age, histopathology, type of therapy, and associated comorbidities. The aim of this study was to determine the risk factors related to development of thrombosis in patients with prostate cancer in a tertiary care center. Methods Retrospective cohort study that included patients ≥18yo diagnosed with prostate cancer at our institution between 2014 and 2017. Univariate and multivariate analysis were performed including all previously described thrombosis risk factors in cancer patients. Results A total of 101 patients were included. Median age was 72 years (52-92). A total of 23 patients (22.8%) presented with a thrombotic event. Regarding baseline characteristics, patients with thrombosis were older (77 vs. 71 years; p=.015), had lower levels of HDL (40.4 vs. 48 mg/dL; p=.033), and a higher prevalence of primary hypertension (65.2% vs.34.6%; p=.009). In patients with thrombosis, 52.2% (n=12) were venous thrombosis and 47.8% (n=11) were arterial. The most common events were pulmonary thromboembolism (n=7; 58.3%) for venous thrombosis and acute coronary syndromes (n=6; 54.5%) for arterial events. In univariate analysis risk factors related to the development of thrombosis were: prostration > 3 days (p=.039), immobility (p=.023), central venous catheter (p=.004), congestive heart failure (p=.021), history of TE (p=.021), major surgery (p=.031) and hip fracture (p=.021). Table 1. On multivariate analysis factors that remained statistically significant were: central venous catheter OR 8.8 (CI 95% 2.2-35.7, p=.002), previous thrombosis OR 10.3 (CI 95% 1.5-72.8, p=.020), and hip fracture OR 8.5 (CI 95% 1.2-63.5,p=.037). Conclusions In conclusion, our study confirms findings from previous studies regarding factors that significantly predispose cancer patients to thrombosis development. Considering our population age, it is not surprising that risk factors in patients with prostate cancer were mainly related to the presence of other comorbiditiesparticularly cardiovascular and atherothrombotic disease. The main risk factor was history of previous thrombosis, suggesting that closer and prolonged anticoagulation therapy should be consider. Multicenter prospective studies most be urged in our population to asses and validate risk factors, and design prognostic scores that can help on determining which patients could be candidates to early intervention modifying preexisting factors and/or receiving prophylactic dose of anticoagulants. Disclosures No relevant conflicts of interest to declare.

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