Purification of Gekko Small Peptide Fraction and Its Effect of Inducing Apoptosis of EC 9706 Esophageal Cancer Cells by Inhibiting PI3K/Akt/GLUT1 Signaling Pathway

2021 ◽  
Vol 18 (3) ◽  
Author(s):  
Xingzhi Lv ◽  
Ruifang Li ◽  
Zhongjie Li ◽  
Jiangang Wang
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Small Peptide ◽  
Peptide Fraction ◽  
Esophageal Cancer Cells

scholarly journals Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway

2020 ◽  
Vol 11 (10) ◽  
Author(s):  
Ying Gao ◽  
Dan-Lei Chen ◽  
Mi Zhou ◽  
Zhou-san Zheng ◽  
Mei-Fang He ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Caspase 3 ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Expression Levels ◽  
In Vivo Animal Model ◽  
Esophageal Cancer Cells

Abstract Although cisplatin (cDDP), is a first-line chemotherapy drug for esophageal cancer, it still has the potential to develop drug resistance and side effects. There is increasing evidence that cordycepin can work synergistically with other chemotherapy drugs. Therefore, we investigated whether combination therapy of cordycepin and cDDP may enhance the therapeutic effect of cDDP. We performed a series of functional tests to study the effect of medical treatment on esophageal cancer cells. We then used GO analysis to examine the pathways affected by treatment with cordycepin and cDDP. Next, we observed changes in the abundance of the selected pathway proteins. The in vivo animal model supported the results of the in vitro experiments. Co-treatment with cordycepin and cDDP inhibited cell growth, migration, and metastasis, as well as induced apoptosis. Cordycepin was found to effectively enhance activation of AMPK and inhibited activity of AKT. In all treatment groups, the expression levels of p-PI3K, p-Akt, p-p70S6K, Caspase-3, and Bcl-2 were significantly reduced, while the expression levels of p-AMPK, cleaved Caspase-3, and Bax increased, and the total levels of Akt, PI3K, and p70S6K levels remained unchanged. Overall, cordycepin was found to enhance the chemical sensitivity of esophageal cancer cells to cisplatin by inducing AMPK activation and inhibiting the AKT signaling pathway. Combination therapy of cordycepin and cisplatin represent a novel potential treatment of esophageal cancer.

scholarly journals Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: Activation of the mitochondria-dependent death-signaling pathway

2003 ◽  
Vol 125 (5) ◽  
pp. 1132-1142 ◽  
Author(s):  
Dao M. Nguyen ◽  
William D. Schrump ◽  
Wilson S. Tsai ◽  
Aaron Chen ◽  
John H. Stewart ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Esophageal Cancer Cells

Thymoquinone inhibits the proliferation and invasion of esophageal cancer cells by disrupting the AKT / GSK ‐3β/Wnt signaling pathway via PTEN upregulation

2020 ◽  
Vol 34 (12) ◽  
pp. 3388-3399 ◽  
Author(s):  
Jingjing Ma ◽  
Yunting Zhang ◽  
Huan Deng ◽  
Yinghui Liu ◽  
Xiaofei Lei ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Gsk 3Β ◽  
Esophageal Cancer Cells ◽  
Proliferation And Invasion

The 3-deoxysappanchalcone induces ROS-mediated apoptosis and cell cycle arrest via JNK/p38 MAPKs signaling pathway in human esophageal cancer cells

Phytomedicine ◽  
2021 ◽  
pp. 153564
Author(s):  
Ah-Won Kwak ◽  
Myeoung-Jun Lee ◽  
Mee-Hyun Lee ◽  
Goo Yoon ◽  
Seung-Sik Cho ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Esophageal Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cycle Arrest ◽  
Human Esophageal Cancer ◽  
Esophageal Cancer Cells ◽  
P38 Mapks

scholarly journals Id-1 activation of PI3K/Akt/NF B signaling pathway and its significance in promoting survival of esophageal cancer cells

2007 ◽  
Vol 28 (11) ◽  
pp. 2313-2320 ◽  
Author(s):  
B. Li ◽  
P. Y. Cheung ◽  
X. Wang ◽  
S. W. Tsao ◽  
M. T. Ling ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Esophageal Cancer Cells

METTL3 promotes the proliferation and invasion of esophageal cancer cells partly through AKT signaling pathway

2020 ◽  
Vol 216 (9) ◽  
pp. 153087
Author(s):  
Huaying Hou ◽  
Huidong Zhao ◽  
Xiaoming Yu ◽  
Ping Cong ◽  
Yong Zhou ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Esophageal Cancer Cells ◽  
Proliferation And Invasion

scholarly journals Silencing of S-phase kinase-associated protein 2 enhances radiosensitivity of esophageal cancer cells through inhibition of PI3K/AKT signaling pathway

Genomics ◽  
2020 ◽  
Vol 112 (5) ◽  
pp. 3504-3510
Author(s):  
Chunying Wang ◽  
Shimeng Li ◽  
Jin Liu ◽  
Ming Cheng ◽  
Dewen Wang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
S Phase ◽  
Akt Signaling Pathway ◽  
Esophageal Cancer Cells
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