scholarly journals The human ISG12a gene is a novel caspase dependent and p53 independent pro-apoptotic gene, that is overexpressed in breast cancer

2013 ◽  
Vol 20 (2) ◽  
pp. 37-46 ◽  
Author(s):  
Efrat Makovitzki-Avraham ◽  
Vered Daniel-Carmi ◽  
Zoya Alteber ◽  
Marganit Farago ◽  
Esther Tzehoval ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Apoptotic Gene

Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple‐negative breast cancer: Caspase, ΔΨm, and pro‐apoptotic gene involvement

2020 ◽  
Vol 34 (6) ◽  
pp. 671-686 ◽  
Author(s):  
Vida Celeste Rosas‐González ◽  
Martha Cecilia Téllez‐Bañuelos ◽  
Georgina Hernández‐Flores ◽  
Alejandro Bravo‐Cuellar ◽  
Adriana Aguilar-Lemarroy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Luminal A ◽  
Differential Effects ◽  
Apoptotic Gene

Abstract P1-04-02: The Role ofBIK (BCL-2 Interaction Killer)Pro-Apoptotic Gene in Breast Cancer

2010 ◽  
Author(s):  
A Rangaraj ◽  
L Ye ◽  
KG Harding ◽  
RE Mansel ◽  
WG. Jiang
Keyword(s):  
Breast Cancer ◽  
Apoptotic Gene

Distribution of Coding Apoptotic Gene Polymorphisms in Women with Extreme Phenotypes of Breast Cancer Predisposition and Tolerance

2011 ◽  
Vol 97 (2) ◽  
pp. 248-251 ◽  
Author(s):  
Yulia M Ulybina ◽  
Ekatherina S Kuligina ◽  
Nathalia V Mitiushkina ◽  
Nathalia Y Sherina ◽  
Dmitry V Baholdin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphisms ◽  
Cancer Predisposition ◽  
Apoptotic Gene ◽  
Breast Cancer Predisposition ◽  
Extreme Phenotypes

scholarly journals LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK

Oncotarget ◽  
2016 ◽  
Vol 7 (49) ◽  
pp. 81452-81462 ◽  
Author(s):  
Xinxin Si ◽  
Ruochen Zang ◽  
Erbao Zhang ◽  
Yue Liu ◽  
Xiao Shi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epigenetic Silencing ◽  
Apoptotic Gene ◽  
Positive Breast Cancer

scholarly journals Apoptotic Potential of Secretome from Interleukin-Induced Natural Killer Cells toward Breast Cancer Cell Line by Transwell Assay

2020 ◽  
Vol 27 (3) ◽  
pp. 186
Author(s):  
Wahyu Widowati ◽  
Diana Krisanti Jasaputra ◽  
Teresa Liliana Wargasetia ◽  
The Fransiska Eltania ◽  
Alya Mardhotillah Azizah ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Quantitative Polymerase Chain Reaction ◽  
Cancer Cell Line ◽  
Transwell Assay ◽  
Apoptotic Gene ◽  
Cause Of Deaths

Breast cancer (BC) is the number one cause of deaths from cancer in women. Metastasis in BC is caused by immunosurveillance deficiency, including impairment of Natural Killer (NK) cell maturation, low NK activity, and decreasing cytotoxicity. This study was performed to improve activating receptors and cytotoxicity of NK cells using interleukin 15 (IL15) against BC cells. Human recombinant IL15 was used to induce NK cells. To evaluate the potential of IL15 in inducing NK cells, we measured the activating and inhibiting receptors (NKG2D, NKG2A), apoptotic potency of NK cells on BC cells (MCF7) using transwell assay. The IL15 inducer  on the NK cell were measured NKG2D, NKG2A gene expression with quantitative polymerase chain reaction (qPCR), (GzmB) secretion using ELISA, apoptotic gene expression of MCF7 using qPCR. IL15 increased NKG2D expression 4.01-9.13%, but IL15 could not affect toward NKG2A expression on NK cells. IL15-activated NK cells, inhibited BC cells proliferation, induced apoptotic BC cells 25.89-32.19%, induced apoptotic genes of BC cells bax, p53. IL15 increase NK activating receptor (NKG2D), inhibit BC cells proliferation, induce apoptotic percentage and induce apoptotic gene expression.

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