RACK1 mediates the advanced glycation end product‐induced degradation of HIF‐1α in nucleus pulposus cells via competing with HSP90 for HIF‐1α binding

2021 ◽  
Author(s):  
Yi‐Chang Xu ◽  
Yong Gu ◽  
Jia‐Ying Yang ◽  
Kun Xi ◽  
Jin‐Cheng Tang ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Advanced Glycation ◽  
Nucleus Pulposus Cells ◽  
Advanced Glycation End Product

Transplantation of Activated Nucleus Pulposus Cells after Cryopreservation: Efficacy Study in Canine Disc Degeneration Model

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376573-s-0034-1376573
Author(s):  
T. Nukaga ◽  
D. Sakai ◽  
A. Hiyama ◽  
T. Ishii ◽  
T. Nakai ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Efficacy Study ◽  
Nucleus Pulposus Cells

Rhinacanthins-rich extract: A potent superoxide scavenger and advanced glycation end-product formation inhibitor

2017 ◽  
Author(s):  
A Shah Muhammad ◽  
H Muhammad ◽  
R Khalil ◽  
Z Ul-Haq ◽  
P Panichayupakaranant
Keyword(s):  
Product Formation ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Superoxide Scavenger

Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation

Diabetes ◽  
1993 ◽  
Vol 42 (2) ◽  
pp. 221-232 ◽  
Author(s):  
R. G. Tilton ◽  
K. Chang ◽  
K. S. Hasan ◽  
S. R. Smith ◽  
J. M. Petrash ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Vascular Dysfunction ◽  
Product Formation ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Oxide Synthase

Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells

Diabetes ◽  
1997 ◽  
Vol 46 (9) ◽  
pp. 1481-1490 ◽  
Author(s):  
A. Bierhaus ◽  
S. Chevion ◽  
M. Chevion ◽  
M. Hofmann ◽  
P. Quehenberger ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Cultured Endothelial Cells ◽  
Nf Kappab

Sirtuin 1 Maitains Survival via PKB Signaling in Degenerative Human Disc Nucleus Pulposus Cells*

2012 ◽  
Vol 39 (6) ◽  
pp. 563-573
Author(s):  
Da-Wu WANG ◽  
Zhen-Ming HU ◽  
Jie HAO ◽  
Bin HE ◽  
Qiang GAN ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Sirtuin 1 ◽  
Nucleus Pulposus Cells

scholarly journals Advanced glycation end product levels were correlated with inflammation and carotid atherosclerosis in type 2 diabetes patients

2020 ◽  
Vol 15 (1) ◽  
pp. 364-372 ◽  
Author(s):  
Jie Li ◽  
Haiyan Shangguan ◽  
Xiaoqian Chen ◽  
Xiao Ye ◽  
Bin Zhong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Color Doppler ◽  
Enzyme Linked Immunosorbent Assay ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Inflammatory Status ◽  
Tnf Α ◽  
Ifn Γ

AbstractDiabetes mellitus with atherosclerosis (AS) adds to the social burden. This study aimed to investigate whether advanced glycation end product (AGE) levels were correlated with inflammation and carotid AS (CAS) in type 2 diabetes mellitus (T2DM) patients. A total of 50 elderly T2DM patients and 50 age-matched senior healthy subjects were recruited in this study. T2DM patients were classified into two groups based on the intima–media thickness (IMT) of the carotid artery from color Doppler ultrasonography. Patients with IMT > 1 mm were classified into the T2DM + CAS group (n = 28), and patients with IMT < 1 mm were assigned as the T2DM + non-atherosclerosis (NAS) group (n = 22). The plasma levels of AGEs, receptor for AGE (RAGE), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) of all subjects were measured by enzyme-linked immunosorbent assay. The T-lymphocyte subsets were analyzed by a flow detector. T2DM + CAS patients showed significantly higher concentrations of AGEs, RAGE, TNF-α, and IFN-γ in the peripheral blood. The highest levels of CD4+ T cells were observed in the T2DM + CAS group. The AGE level was positively correlated with the concentrations of RAGE, TNF-α, IFN-γ, and CD4+. In summary, the results showed that the levels of AGEs may be correlated with the inflammatory status in T2DM patients with CAS.

scholarly journals The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells

2021 ◽  
Vol 54 (2) ◽  
Author(s):  
Wencan Ke ◽  
Bingjin Wang ◽  
Wenbin Hua ◽  
Yu Song ◽  
Saideng Lu ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Compression Stress ◽  
Nucleus Pulposus Cells ◽  
Myosin Iia
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