Epithelial cell adhesion molecule promotes breast cancer resistance protein ‐mediated multidrug resistance in breast cancer by inducing partial epithelial‐mesenchymal transition

2021 ◽  
Author(s):  
Rui‐Zan Shi ◽  
Yi‐Fan He ◽  
Jie Wen ◽  
Ya‐Nan Niu ◽  
Yu Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Epithelial Cell ◽  
Breast Cancer Resistance Protein ◽  
Cell Adhesion Molecule ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Resistance ◽  
Epithelial Cell Adhesion Molecule ◽  
Mesenchymal Transition ◽  
Resistance Protein

scholarly journals Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitoxantrone-Selected Cell Lines

1999 ◽  
Vol 91 (5) ◽  
pp. 429-433 ◽  
Author(s):  
D. D. Ross ◽  
W. Yang ◽  
L. V. Abruzzo ◽  
W. S. Dalton ◽  
E. Schneider ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cell Lines ◽  
Messenger Rna ◽  
Breast Cancer Resistance Protein ◽  
Rna Expression ◽  
Cancer Resistance ◽  
Resistance Protein

scholarly journals Phytoestrogens/Flavonoids Reverse Breast Cancer Resistance Protein/ABCG2-Mediated Multidrug Resistance

2004 ◽  
Vol 64 (12) ◽  
pp. 4346-4352 ◽  
Author(s):  
Yasuo Imai ◽  
Satomi Tsukahara ◽  
Sakiyo Asada ◽  
Yoshikazu Sugimoto
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
Resistance Protein

scholarly journals Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells

2015 ◽  
Vol 34 (3) ◽  
pp. 1169-1177 ◽  
Author(s):  
TERUYA NAGAHARA ◽  
HIDENORI SHIRAHA ◽  
HIROAKI SAWAHARA ◽  
DAISUKE UCHIDA ◽  
YASUTO TAKEUCHI ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Adhesion Molecule ◽  
Hepatic Stellate Cells ◽  
Cell Adhesion Molecule ◽  
Epithelial Mesenchymal Transition ◽  
Stellate Cells ◽  
Hepatic Cancer ◽  
Epithelial Cell Adhesion Molecule ◽  
Mesenchymal Transition

Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Mediate the Disposition of Leonurine-10-O-β-glucuronide

2020 ◽  
Vol 21 (13) ◽  
pp. 1060-1067
Author(s):  
Xiaocui Li ◽  
Yushan Xie ◽  
Wei Qu ◽  
Xiaojun Ou ◽  
Xiaowen Ou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Breast Cancer Resistance Protein ◽  
Gene Knockout ◽  
Multidrug Resistance Protein ◽  
Cancer Resistance ◽  
Wild Type ◽  
Multidrug Resistance Protein 2 ◽  
Intestinal Microsomes ◽  
Resistance Protein

Background: Leonurine (Leo), a promising antilipemic agent that has been approved for clinical trials, is extensively metabolized into bioactive Leonurine-10-O-β-glucuronide (L-10-G) vivo. Objective: To explore the effects of breast cancer resistance protein (Bcrp) and multidrug resistance protein 2 (Mrp2) on the disposition of L-10-G. Methods: The pharmacokinetics, tissue distribution and intestinal perfusion of Leo were studied by using efflux transporter gene knockout mouse models. The enzyme kinetics via liver and intestinal microsomes were also examined. Results: After intravenous injection with Leo, the AUC0-∞ values of L-10-G in Bcrp1-/- and Mrp2-/- mice were 1.55-fold and 16.80-fold higher, respectively, than those in wild-type FVB mice (P < 0.05). After oral administration, the AUC0-∞ value of L-10-G showed a 2.82-fold increase in Mrp2-/- mice compared with wild-type FVB mice (P < 0.05). After gavage with Leo for 10 and 25 min, the bile accumulation of L-10-G in Mrp2-/- mice was 3-fold and 22-fold lower, respectively, than that in wild-type FVB mice (P < 0.05). Besides, the intestinal excreted amount of L-10-G showed 2.22-fold and 2.68-fold decrease in Bcrp1-/- and Mrp2-/- mice, respectively, compared with that in wild-type FVB mice (P < 0.05). The clearance of L-10-G decreased in liver microsomes and increased in intestinal microsomes of Bcrp1-/- and Mrp2-/- mice compared to the wild-type FVB mice (P < 0.05). Conclusion: Both Bcrp and Mrp2 are involved in the disposition of L-10-G, and Mrp2 exhibits a superior influence.

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