Germacrone improves liver fibrosis by regulating the PI3K/AKT/mTOR signalling pathway

2021 ◽  
Author(s):  
De Ji ◽  
Qi Zhao ◽  
Yuwen Qin ◽  
Huangjin Tong ◽  
Qiaohan Wang ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Tenofovir disoproxil fumarate directly ameliorates liver fibrosis by inducing hepatic stellate cell apoptosis via downregulation of PI3K/Akt/mTOR signaling pathway

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261067
Author(s):  
Sung Won Lee ◽  
Sung Min Kim ◽  
Wonhee Hur ◽  
Byung-Yoon Kang ◽  
Hae Lim Lee ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Tenofovir Disoproxil Fumarate ◽  
Stellate Cell ◽  
Antiviral Agent ◽  
Underlying Mechanism ◽  
Signalling Pathway ◽  
Long Term Treatment ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

Background Antifibrotic agent for the treatment of liver fibrosis has not been developed so far. Long term treatment of chronic hepatitis B patients with antiviral drugs tenofovir disoproxil fumarate (TDF) and entecavir (ETV) results in the regression of liver fibrosis, but the underlying mechanism has not been clarified. Therefore, we aimed to investigate the direct impact of TDF and ETV on liver fibrosis. Methods Activated hepatic stellate cell (HSC) cell lines were used to evaluate the effects of TDF and ETV. After treatment with each antiviral agent, cell viability, morphology, apoptotic features, autophagy and antifibrosis signalling pathways were examined. Then, collagen deposition, fibrosis markers and activated HSCs were measured in liver tissues of the liver fibrosis model mice. Results After TDF treatment, the viabilities of LX2 and HSC-T6 cells were decreased, and the cells exhibited apoptotic features, but ETV did not induce these effects. Cleavage of PARP and Caspase-3 and the inhibition of the antiapoptotic gene Bcl-xl indicated activated HSC apoptosis following TDF treatment. TDF simultaneously increased autophagy, which also regulated apoptosis through crosstalk. TDF inactivated the PI3K/Akt/mTOR signalling pathway, which was associated with the activation of both apoptosis and autophagy. In the liver fibrosis mouse model, the fibrotic area and activated HSC markers were decreased by TDF but not ETV treatment. Additionally, apoptotic cells were concentrated in the periportal fibrotic area after TDF treatment, which indicated the specific antifibrotic effect of TDF. Conclusions TDF directly ameliorates liver fibrosis by downregulating the PI3K/Akt/mTOR signalling pathway, which results in the apoptosis of activated HSCs. The antifibrotic effects of TDF indicate that it may be a therapeutic agent for the treatment of liver fibrosis.

scholarly journals Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Kit San Yeung ◽  
Winnie Wan Yee Tso ◽  
Janice Jing Kun Ip ◽  
Christopher Chun Yu Mak ◽  
Gordon Ka Chun Leung ◽  
...  
Keyword(s):  
Developmental Delay ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules

2008 ◽  
Vol 1 (1-4) ◽  
pp. 49-62 ◽  
Author(s):  
Richard M. Gunn ◽  
Helen C. Hailes
Keyword(s):  
Small Molecules ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Hnf1α is required for proper gut epithelial endocrine cell specification and controls the mTOR signalling pathway in mice

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Francois Boudreau ◽  
Carine R Lussier ◽  
Francois Brial ◽  
Nathalie Rivard ◽  
Nathalie Perreault
Keyword(s):  
Endocrine Cell ◽  
Signalling Pathway ◽  
Cell Specification ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals Role of the mTOR Signalling Pathway in Human Sepsis-Induced Myocardial Dysfunction

2019 ◽  
Vol 35 (7) ◽  
pp. 875-883 ◽  
Author(s):  
Wei Cheng MM ◽  
Yun Long ◽  
Hao Wang ◽  
Wen Han MM ◽  
Jiahui Zhang ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Signalling Pathway ◽  
Human Sepsis ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals PD‐1/PD‐L1 blockade rescue exhausted CD8+ T cells in gastrointestinal stromal tumours via the PI3K/Akt/mTOR signalling pathway

2019 ◽  
Vol 52 (3) ◽  
pp. e12571 ◽  
Author(s):  
Rui Zhao ◽  
Yinghan Song ◽  
Yong Wang ◽  
Yuqian Huang ◽  
Zhigui Li ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Signalling Pathway ◽  
Gastrointestinal Stromal Tumours ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals LncRNA MEG3 inhibits rheumatoid arthritis through miR‐141 and inactivation of AKT/mTOR signalling pathway

2019 ◽  
Vol 23 (10) ◽  
pp. 7116-7120 ◽  
Author(s):  
Guoqing Li ◽  
Ying Liu ◽  
Fanru Meng ◽  
Zhongbin Xia ◽  
Xia Wu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signalling Pathway ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

scholarly journals PI3K/Akt/mTOR signalling pathway activation in patients with ER‑positive, metachronous, contralateral breast cancer treated with hormone therapy

2018 ◽  
Author(s):  
Hirofumi Kanaizumi ◽  
Chihiro Higashi ◽  
Yumiko Tanaka ◽  
Mika Hamada ◽  
Wataru Shinzaki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Therapy ◽  
Contralateral Breast Cancer ◽  
Contralateral Breast ◽  
Signalling Pathway ◽  
Pathway Activation ◽  
Er Positive ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway

SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway

2013 ◽  
Vol 136 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Mi Kwon Son ◽  
Kyung Hee Jung ◽  
Sang-Won Hong ◽  
Hee-Seung Lee ◽  
Hong-Mei Zheng ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Signalling Pathway ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells ◽  
Mtor Signalling ◽  
Mtor Signalling Pathway
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