For infants, what are the effects of skin care to prevent or reverse an impaired skin barrier on the development of eczema and food allergies?

2021 ◽  
Author(s):  
Agustín Ciapponi
Keyword(s):  
Skin Barrier ◽  
Skin Care ◽  
Food Allergies

scholarly journals Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis

2020 ◽  
Vol 21 (8) ◽  
pp. 2867 ◽  
Author(s):  
Gabsik Yang ◽  
Jin Kyung Seok ◽  
Han Chang Kang ◽  
Yong-Yeon Cho ◽  
Hye Suk Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Systemic Disease ◽  
Skin Barrier ◽  
Immune Dysregulation ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Barrier Dysfunction ◽  
Underlying Mechanisms ◽  
Chronic Pruritus ◽  
And Function

Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to occur primarily in children, increasing evidence suggests that AD is more common in adults than previously assumed. Accumulating evidence from experimental, genetic, and clinical studies indicates that AD expression is a precondition for the later development of other atopic diseases, such as asthma, food allergies, and allergic rhinitis. Although the exact mechanisms of the disease pathogenesis remain unclear, it is evident that both cutaneous barrier dysfunction and immune dysregulation are critical etiologies of AD pathology. This review explores recent findings on AD and the possible underlying mechanisms involved in its pathogenesis, which is characterized by dysregulation of immunological and skin barrier integrity and function, supporting the idea that AD is a systemic disease. These findings provide further insights for therapeutic developments aiming to repair the skin barrier and decrease inflammation.

Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Care

2012 ◽  
Vol 30 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Simon G. Danby ◽  
Tareq AlEnezi ◽  
Amani Sultan ◽  
Tina Lavender ◽  
John Chittock ◽  
...  
Keyword(s):  
Sunflower Seed ◽  
Seed Oil ◽  
Skin Barrier ◽  
Skin Care ◽  
Sunflower Seed Oil ◽  
Neonatal Skin ◽  
Adult Skin

scholarly journals DISORDERS OF SKIN MICROBIOTA AND FORMATION OF ATOPIC DERMATITIS IN CHILDREN

2019 ◽  
Vol 22 (4) ◽  
pp. 243-250
Author(s):  
Galina I. Smirnova ◽  
A. A. Korsunsky
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
General Concept ◽  
Skin Care ◽  
Special Significance ◽  
Dry Skin ◽  
Skin Microbiota ◽  
Rate Of Development ◽  
The Relationship

The review presents the special significance of changes in the intestinal and skin microbiota in the formation of atopic dermatitis (AD) in children. AD is considered as a form of allergic pathology directly related to the state and quality of the microbiota of a growing organism. The microbiota of the skin of patients with AD is characterized by a small species diversity of bacteria; a decrease in the number of actinomycetes and proteobacteria; increased colonization of various types of staphylococci (S. aureus, S. epidermidis, S. haemolyticus, etc). The relationship between the rate of development of AD and violations of the microbiota of the skin in children is shown. The necessity of maintaining high biodiversity of the microbiota of a growing organism as a strategy for optimizing the microecology of children through the use of adaptive probiotics in a healthy microenvironment is substantiated. The restoration of the barrier function of the skin and the normalization of the composition and quality of the intestinal microbiota are determined as the most important task of the general concept of the treatment of AD, where new dermatological cosmetics and proper skin care play an important role. The possibilities of normalizing the microbiome of the affected skin areas to restore the skin barrier with the help of dry skin care cosmetics are shown.

scholarly journals A Bibliometric Analysis of Atopic Dermatitis Research over the Past Three Decades and Future Perspectives

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1749
Author(s):  
Dongwon Kim ◽  
Younbyoung Chae ◽  
Hi-Joon Park ◽  
In-Seon Lee
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Skin Barrier ◽  
Food Allergies ◽  
Annual Number ◽  
Network Analyses ◽  
The Past ◽  
Keywords Atopic Dermatitis ◽  
The Usa ◽  
The Uk

Atopic dermatitis (AD) has been increasing in prevalence over the past few decades; however, AD has never been analyzed using a bibliometric approach. We searched for AD studies in the dermatology and allergy category of the Web of Science and SCOPUS databases using the keywords “atopic dermatitis”, “eczema”, and “atopy”. In total, 53,460 documents were retrieved. We analyzed annual publication trends and performed keyword and co-authorship network analyses. The annual number of AD publications has increased over the years. Asthma, food allergies, the skin barrier, IgE, and epidemiology have received extensive attention. The keywords ‘allergic rhinitis’, ‘child(ren)’, ‘quality of life’, and ‘probiotics’ have become more commonly used in recent years. AD research has been led by only a few countries, such as the USA, Germany, and the UK, and longstanding research topics such as asthma, allergy, and the immune system continue to be important. We suggest that global collaborations, research in developing countries, and research that is more holistic (thus exploring how genes, the immune system, the environment, and the microbiome together impact AD) are necessary.

scholarly journals Role of PAR1 in Food Allergies

2020 ◽  
Vol 3 ◽  
Author(s):  
Jennifer Garcia ◽  
Lauren Buelow ◽  
Joan Cook-Mills
Keyword(s):  
Food Allergy ◽  
Skin Barrier ◽  
Food Allergies ◽  
Neonatal Mice ◽  
Signaling Mechanisms ◽  
Skin Keratinocytes ◽  
Potential Impact ◽  
Fungal Allergen ◽  
Deficient Mice

Background and Hypothesis:  The prevalence of food allergies continues to rise. In a mouse model, food allergy to peanuts develops in flaky tail mice with skin barrier mutations and exposure to peanut (PNE) and Alternaria Alternata (fungal allergen, Alt) on the skin. In the skin, keratinocytes respond to proteases in allergens through protease activating receptor 1 (PAR1). Blocking PAR1 decreased the severity of viral induced inflammation in mice. Whether PAR1 has a major role in food allergies has not been investigated. We tested the hypothesis that blocking PAR1 would halt the development of food allergy to peanuts in neonatal mice.    Project Methods:  In our studies, pups were injected intradermally (i.d.) with a PAR1 antagonist and then treated with PNE/Alt. In another group, pups received i.d. injections of a PAR1 agonist and then treated with PNE only. Control groups received allergens only. Pups were treated and skin sensitized 5 times every 3-4 days. Forty-eight hours after the last treatment, pups were challenged with PNE through oral gavage, and temperatures were recorded every 15-30 minutes for 3 hours. Skin, ileum, and jejunum samples were collected and used for qPCR to determine the expression of inflammatory mediators. Plasma serum was used for analysis of anti-PNE specific antibodies by ELISA.      Results:   PAR1 antagonist blocked anaphylaxis in allergic mice sensitized with PNE and Alt. PAR1 agonist is sufficient to induce anaphylaxis in mice sensitized with PNE only.     Conclusion and Potential Impact:  This study demonstrates that PAR1 is involved in the development of food allergies, where blocking the receptor blocked food allergies in neonatal mice. The signaling mechanisms and activators of PAR1 need further studies, using PAR1 deficient mice. This novel pathway may lead to therapies to stop the development of food allergies. 

Stratum Corneum Skin Barrier Maintenance and Restoration: Evidence-Based Approach to Cleansing and Other Skin Care Practices

2013 ◽  
Vol 32 (2S) ◽  
pp. S30-S32 ◽  
Author(s):  
Paul Horowitz ◽  
Renee McLeod ◽  
Lawrence Eichenfield ◽  
Joseph Fowler ◽  
Peter Elias
Keyword(s):  
Stratum Corneum ◽  
Skin Barrier ◽  
Skin Care ◽  
Evidence Based ◽  
Care Practices
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