scholarly journals DISORDERS OF SKIN MICROBIOTA AND FORMATION OF ATOPIC DERMATITIS IN CHILDREN

2019 ◽  
Vol 22 (4) ◽  
pp. 243-250
Author(s):  
Galina I. Smirnova ◽  
A. A. Korsunsky
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
General Concept ◽  
Skin Care ◽  
Special Significance ◽  
Dry Skin ◽  
Skin Microbiota ◽  
Rate Of Development ◽  
The Relationship

The review presents the special significance of changes in the intestinal and skin microbiota in the formation of atopic dermatitis (AD) in children. AD is considered as a form of allergic pathology directly related to the state and quality of the microbiota of a growing organism. The microbiota of the skin of patients with AD is characterized by a small species diversity of bacteria; a decrease in the number of actinomycetes and proteobacteria; increased colonization of various types of staphylococci (S. aureus, S. epidermidis, S. haemolyticus, etc). The relationship between the rate of development of AD and violations of the microbiota of the skin in children is shown. The necessity of maintaining high biodiversity of the microbiota of a growing organism as a strategy for optimizing the microecology of children through the use of adaptive probiotics in a healthy microenvironment is substantiated. The restoration of the barrier function of the skin and the normalization of the composition and quality of the intestinal microbiota are determined as the most important task of the general concept of the treatment of AD, where new dermatological cosmetics and proper skin care play an important role. The possibilities of normalizing the microbiome of the affected skin areas to restore the skin barrier with the help of dry skin care cosmetics are shown.

scholarly journals SKIN MICROBIOTA AND ATOPIC DERMATITIS IN CHILDREN: NEW TREATMENT OPTIONS

2019 ◽  
Vol 21 (2) ◽  
pp. 106-113
Author(s):  
Galina I. Smirnova ◽  
D. B. Munblit ◽  
A. I. Kolotilina ◽  
D. M. Levina
Keyword(s):  
Atopic Dermatitis ◽  
Treatment Options ◽  
Skin Barrier ◽  
General Concept ◽  
Small Species ◽  
Dry Skin ◽  
Skin Microbiota ◽  
New Treatment ◽  
The Relationship

There are presented data characterizing atopic dermatitis (AD) in children as a form of allergic pathology, directly related to the condition and quality of the microbiota (intestinal and skin) of the growing organism. The microbiota of the affected skin of AD patients is characterized by a small species diversity of bacteria; the decrease in the number of actinomycetes and proteobacteria; increased colonization by various types of staphylococci (etc.). The relationship between the rate of formation of AD and the disturbance of the skin microbiota in children has been established. The concept of the preservation of high biodiversity of microbiota of a growing organism as a strategy for optimizing microecology of children by using adaptive probiotics in a healthy microenvironment is proposed. The restoration of the barrier function of the skin is determined as the most important task included in the general concept of the treatment of AD, where a significant role is assigned to new means of dermatological cosmetics and proper skin care. The possibilities of normalization the microbiota of affected areas of the skin with the help of cosmetic means for the care of dry skin are shown as a result of the restoration of the skin barrier.

Influence of Appropriate Skin Care on Facial Skin Physiology and Quality of Life in Atopic Dermatitis Patients

2013 ◽  
Vol 75 (1) ◽  
pp. 65-71
Author(s):  
Katsuko KIKUCHI ◽  
Maki OZAWA ◽  
Setsuya AIBA ◽  
Eishin MORITA
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Skin Care ◽  
Facial Skin ◽  
Skin Physiology

The Relationship Between Sensory Hypersensitivity and Sleep Quality of Children with Atopic Dermatitis

2009 ◽  
Vol 26 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Ayelet Shani-Adir ◽  
Dganit Rozenman ◽  
Aharon Kessel ◽  
Batya Engel-Yeger
Keyword(s):  
Atopic Dermatitis ◽  
Sleep Quality ◽  
Sensory Hypersensitivity ◽  
The Relationship

scholarly journals Shifts in the Skin Microbiota after UVB Treatment in Adult Atopic Dermatitis

Dermatology ◽  
2021 ◽  
pp. 1-12
Author(s):  
Astrid Haaskjold Lossius ◽  
Olav Sundnes ◽  
Anna Cäcilia Ingham ◽  
Sofie Marie Edslev ◽  
Jørgen Vildershøj Bjørnholt ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Temporal Dynamics ◽  
Skin Barrier ◽  
16S Rrna Gene Sequencing ◽  
Ultraviolet B ◽  
Rrna Gene ◽  
Skin Microbiota ◽  
Lesional Skin ◽  
Before And After ◽  
Nose And Throat

<b><i>Background:</i></b> The pathophysiology in atopic dermatitis (AD) is not fully understood, but immune dysfunction, skin barrier defects, and alterations of the skin microbiota are thought to play important roles. AD skin is frequently colonized with <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and microbial diversity on lesional skin (LS) is reduced compared to on healthy skin. Treatment with narrow-band ultraviolet B (nb-UVB) leads to clinical improvement of the eczema and reduced abundance of <i>S. aureus</i>. However, in-depth knowledge of the temporal dynamics of the skin microbiota in AD in response to nb-UVB treatment is lacking and could provide important clues to decipher whether the microbial changes are primary drivers of the disease, or secondary to the inflammatory process. <b><i>Objectives:</i></b> To map the temporal shifts in the microbiota of the skin, nose, and throat in adult AD patients after nb-UVB treatment. <b><i>Methods:</i></b> Skin swabs were taken from lesional AD skin (<i>n</i> = 16) before and after 3 treatments of nb-UVB, and after 6–8 weeks of full-body treatment. We also obtained samples from non-lesional skin (NLS) and from the nose and throat. All samples were characterized by 16S rRNA gene sequencing. <b><i>Results:</i></b> We observed shifts towards higher diversity in the microbiota of lesional AD skin after 6–8 weeks of treatment, while the microbiota of NLS and of the nose/throat remained unchanged. After only 3 treatments with nb-UVB, there were no significant changes in the microbiota. <b><i>Conclusion:</i></b> Nb-UVB induces changes in the skin microbiota towards higher diversity, but the microbiota of the nose and throat are not altered.

scholarly journals Pruritus and Atopic Dermatitis: from Etiological Features to Management

2020 ◽  
Vol 19 (6) ◽  
pp. 468-476
Author(s):  
Nikolay N. Murashkin ◽  
Leonid A. Opryatin ◽  
Roman V. Epishev ◽  
Alexander I. Materikin ◽  
Eduard T. Ambarchian ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Clinical Studies ◽  
Clinical Manifestations ◽  
Skin Barrier ◽  
Current Data ◽  
Scientific Images

Pruritus is one of the main clinical manifestations of atopic dermatitis, and it significantly reduces the quality of life of patients in childhood. Scientific images on its pathophysiological basis have now undergone significant changes. The histamine exceptional role in pruritus development was confounded, as well as data on immune system involvement in its maintenance was given. This article presents current data on differential approaches to pruritus management depending on its etiopathogenetic characteristics. The role of dermocosmetics in restoration of the skin barrier as the first stage prevention of pruritus in atopic dermatitis was considered. The results of clinical studies showing efficacy of topical agents (innovative component with anti-pruritic action — STIMU-TEX) application are presented.

scholarly journals Oxidative Stress in Atopic Dermatitis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Hongxiu Ji ◽  
Xiao-Kang Li
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Treatment Strategies ◽  
Scientific Progress ◽  
Skin Barrier ◽  
Skin Aging ◽  
Barrier Defect ◽  
Pruritic Skin

Atopic dermatitis (AD) is a chronic pruritic skin disorder affecting many people especially young children. It is a disease caused by the combination of genetic predisposition, immune dysregulation, and skin barrier defect. In recent years, emerging evidence suggests oxidative stress may play an important role in many skin diseases and skin aging, possibly including AD. In this review, we give an update on scientific progress linking oxidative stress to AD and discuss future treatment strategies for better disease control and improved quality of life for AD patients.

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