A prospective, single-center, randomized study to assess whether automated coregistration of optical coherence tomography with angiography can reduce geographic miss

2018 ◽  
Vol 93 (3) ◽  
pp. 411-418 ◽  
Author(s):  
Kohei Koyama ◽  
Akiko Fujino ◽  
Akiko Maehara ◽  
Myong Hwa Yamamoto ◽  
Dragos Alexandru ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Randomized Study ◽  
Optical Coherence ◽  
Single Center ◽  
Geographic Miss

scholarly journals Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study

2015 ◽  
Vol 7 (4) ◽  
pp. 459 ◽  
Author(s):  
Ronni Wessels ◽  
DanielM. De Bruin ◽  
DirkJ Faber ◽  
Simon Horenblas ◽  
BasW.G van Rhijn ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Prospective Study ◽  
Optical Coherence ◽  
Single Center ◽  
Malignant Lesions

Trends and outcomes of optical coherence tomography use: 877 patients single-center experience

2019 ◽  
Vol 20 (4) ◽  
pp. 303-310 ◽  
Author(s):  
Lazzaro Paraggio ◽  
Francesco Burzotta ◽  
Cristina Aurigemma ◽  
Renato Scalise ◽  
Antonio Maria Leone ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Single Center ◽  
Single Center Experience

scholarly journals Short-Term Effects of Dark Chocolate on Retinal and Choriocapillaris Perfusion in Young, Healthy Subjects Using Optical Coherence Tomography Angiography

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 664
Author(s):  
Gianluca Scuderi ◽  
Chiara Ciancimino ◽  
Fabian D’Apolito ◽  
Maurizio Maurizi Enrici ◽  
Fabio Guglielmelli ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Visual Function ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Randomized Study ◽  
Dark Chocolate ◽  
Optical Coherence ◽  
Flow Area ◽  
Positive Effects

(1) Aim: Contrasting results have been published on the effect of dark chocolate on visual function. The aim of this study was to evaluate retinal and choriocapillaris perfusion, using optical coherence tomography angiography (OCT-A), and visual function in healthy subjects following dark chocolate ingestion. (2) Methods: This prospective randomized study was carried out on 18 healthy young subjects at the St. Andrea Hospital, Sapienza, University of Rome. Visual acuity assessment and a complete ophthalmologic examination were carried out at baseline. In session one, each subject was randomized to eat either a 100 g dark chocolate bar or a 100 g white chocolate bar. In session two, the opposite chocolate was given to each participant. OCT-A and best corrected visual acuity (BCVA) were performed before the chocolate was eaten and repeated 1, 2, and 3 h after that. Retinal vessel density and choriocapillaris flow area were assessed. (3) Results: 18 patients with a mean (SD) age of 26.3 (1.5) years were included. No significant differences between dark or white chocolate were found when evaluating foveal density (%), whole density (%), choriocapillaris flow area, and BCVA. (4) Conclusions: Dark chocolate did not result in significant changes in retinal perfusion and choriocapillaris flow area. However, given the results of other studies showing the positive effects of flavonoids on visual function, further studies are warranted using pure chocolate without other components such as caffeine that can potentially affect results. Furthermore, we cannot rule out the possible benefits of higher doses of flavonoids in dietary supplementation over a more extended period and in a larger patient population.

scholarly journals A New Optical Coherence Tomography Method for Subfoveal Choroidal Thickness Measurement: A Single-center Observational Study

2020 ◽  
Author(s):  
Kyung Tae Kang ◽  
Ji Hye Jang ◽  
Yu Cheol Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Observational Study ◽  
Choroidal Thickness ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
New Method ◽  
Optical Coherence ◽  
Single Center ◽  
Intraclass Correlation Coefficients ◽  
Single Center Observational Study

Abstract Background: Several macular pathologies are associated with choroidal vascular supply, and thus require choroidal thickness evaluation. However, there is no standard subfoveal choroidal thickness (SFCT) measuring method. This study investigated a new method to measure the SFCT, using optical coherence tomography.Methods: This is a single-center observational study. Eighty-two senior medical students participated as observers and independently measured the SFCT on five standard optical coherence tomography images of healthy adults in a tertiary care setting. They used three different methods: (1) the observer’s own method, (2) the conventional method, perpendicular to the retinal pigment epithelium, and (3) the new method, along a virtual line connecting the umbo with the most elevated point of the ellipsoid. Additionally, the SFCT angle—the angle between the measurement line and the vertical line of the image—was measured and compared between methods. The intraclass correlation coefficient was used to determine interpersonal variability. Results: The intraclass correlation coefficients for SFCT measured by methods 1, 2, and 3 were 0.853, 0.880, and 0.896, respectively (P < 0.001 for all). It was the highest with method 3; the intraclass correlation coefficients SFCT angles were 0.647, 0.842, and 0.307, respectively (P < 0.001 for all).Conclusions: The new method showed the lowest interpersonal variability, and could therefore be a reliable standard for SFCT measurement, even in foveae with a steep slope on optical coherence tomography.Trial registration: Not applicable

scholarly journals Effect of Alirocumab on Coronary Plaque in Patients With Coronary Artery Disease Assessed by Optical Coherence Tomography

2021 ◽  
Author(s):  
Fei Gao ◽  
Zhi Jian Wang ◽  
Xiao Teng Ma ◽  
Hua Shen ◽  
Li Xia Yang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Statin Therapy ◽  
Standard Care ◽  
Ldl Cholesterol ◽  
Randomized Study ◽  
Coronary Plaque ◽  
Optical Coherence ◽  
Pcsk9 Inhibitors ◽  
Cholesterol Levels ◽  
The Impact

Abstract Background Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors have been demonstrated with significant greater reduction of LDL cholesterol levels and cardiovascular events, compared with standard statin therapy. However, the evidence on the impact of PCSK9 inhibitors on coronary plaque composition and morphology are limited. Methods In this prospective, open-label, randomized study, eligible patients with intermediate coronary lesions and elevated LDL cholesterol values were randomized to either alirocumab 75 mg Q2W plus statin therapy (alirocumab arm) or statin therapy (standard care arm). Optical coherence tomography (OCT) assessment for target lesions were obtained at the baseline and at 36 weeks of follow-up. Results LDL cholesterol levels were significantly decreased in both alirocumab arm and standard care arm, whereas the absolute reduction of LDL cholesterol was significantly greater in patients with alirocumab (1.72±0.51 vs 0.96±0.59, P<0.0001). Compared with standard statin therapy, the addition of alirocumab to statins was associated with significant greater increase in minimum fibrous cap thickness (18.0 [10.8- 29.2]um vs 13.2 [7.4-18.6]um; P=0.029), minimum lumen area (0.20[ 0.10-0.33]mm 2 vs 0.13 [0.12-0.24]mm 2 ; P=0.006) and greater diminution in maximum lipid arc (15.1 ̊ [7.8 -24.5] vs. 8.4 ̊ [2.0 -10.5]; P=0.008). Conclusions The addition of alirocumab to statins can not only provide additional LDL cholesterol lowering effect but also have a potential role in promoting a more stable plaque phenotype.

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