Synthesis of Benzoisoselenazolones via Rh(III)‐Catalyzed Direct Annulative Selenation Using Elemental Selenium

AbstractTwo common problems with implantation after cancerous tumor resection are cancer recurrence and bacteria infection at the implant site. Tumor resection surgery sometimes can not remove all the cancerous cells, thus, cancer can return after implantation. In addition, bacteria infection is one of the leading causes of implant failure. Therefore, it is desirable to have anti-cancer and anti-bacterial molecules which both rapidly (for anti-infection purposes) and continuously (for anti-cancer purposes) are available at the implant site following implantation. Therefore, the objective of the present in vitro study was to create a multi-functional coating for anti-cancer and anti-bacterial orthopedic implant applications. Elemental selenium was chosen as the biologically active agent in this effort because of its known chemopreventive and anti-bacterial properties. To achieve that objective, titanium (Ti), a conventional orthopedic implant material was coated with selenium (Se) nanoclusters. Different coating densities were achieved by varying Se concentration in the reaction mixture. Titanium substrates coated with Se nanoclusters were shown to enhance healthy osteoblast (bone-forming cell) and inhibit cancerous osteoblast proliferation in co-culture experiments. Functions of S. epidermidis (one of the leading bacteria that infect implants) were inhibited on Ti coated with Se-nanoclusters compared to uncoated materials. Thus, this study provided for the first time a coating material (selenium nanoclusters) to the biomaterials’ community to promote healthy bone cells’ functions, inhibit cancer growth and prevent bacteria infection.

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Three-component reaction between secondary phosphine sulfides, elemental selenium and vinyl ethers: the first examples of Markovnikov addition of thioselenophosphinic acids to double bond

Tetrahedron ◽

10.1016/j.tet.2013.05.038 ◽

2013 ◽

Vol 69 (30) ◽

pp. 6185-6195 ◽

Cited By ~ 4

Author(s):

Ludmila A. Oparina ◽

Alexander V. Artem'ev ◽

Oksana V. Vysotskaya ◽

Nikita A. Kolyvanov ◽

Irina Yu. Bagryanskaya ◽

...

Keyword(s):

Double Bond ◽

Elemental Selenium ◽

Secondary Phosphine ◽

Vinyl Ethers ◽

Three Component Reaction ◽

Markovnikov Addition

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The efficacy of intraruminal pellets composed of elemental selenium and iron in sheep

New Zealand Veterinary Journal ◽

10.1080/00480169.1988.35480 ◽

1988 ◽

Vol 36 (2) ◽

pp. 53-55 ◽

Cited By ~ 4

Author(s):

K.R. Millar ◽

W.J. Meads

Keyword(s):

Elemental Selenium

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ANTIOXIDANT ACTIVITY AND BIOGENIC SYNTHESIS OF SELENIUM NANOPARTICLES USING THE LEAF EXTRACT OF ALOE VERA

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2017v9i4.20981 ◽

2017 ◽

Vol 9 (4) ◽

pp. 147 ◽

Cited By ~ 3

Author(s):

Jay Vyas ◽

Shafkat Rana

Keyword(s):

Antioxidant Activity ◽

Aloe Vera ◽

Selenium Nanoparticles ◽

Spherical Particles ◽

Elemental Selenium ◽

Biogenic Synthesis ◽

Transmission Electron ◽

Ft Ir ◽

Ir Analysis ◽

Chemoprevention Agent

Objective: The objective of this present study were to the biogenic synthesis of selenium nanoparticles using Aloe vera extract and check it’s antioxidant potential by ABTS, DPPH and FRAP assays.Methods: In this study we investigated the clove of Aloe vera, which is used for the synthesis of selenium nanoparticles were characterized by using UV-Visible (UV-VIS) spectrophotometer, Transmission electron microscopy (TEM), Fourier transform spectroscopy (FTIR) and Energy dispersive X-Ray spectroscopy (EDAX) and ABTS, DPPH and FRAP assays for checked it’s antioxidant potential.Results: The present study was carried out to synthesis of Selenium nanoparticles using extract of Aloe vera. UV-Vis Spectra at 350 nm with Aloe vera extract and observed as hollow and spherical particles in size ranging 7-48 nm which is found more stable more than two months. EDAX analysis was carried out to check the presoak of Selenium in nanoparticles. Results of EDAX, confirmed its present. TEM and SEAD represented addition evidence of formation of nanoparticles whereas SEAD indicates the particles were crystalline in nature. FT-IR analysis was carried out to identify the possible bio molecules and Aloe vera extract-metal ions interaction responsible for formation and stabilization of selenium nanoparticles. FRAP, ABTS and DPPH assay results sequester that Selenium nanoparticles prepared using Aloe vera extract possess more activity than extract alone.Conclusion: The bio molecules of Aloe veraextract acted as stabilizing as well as capping agent leading to the formation of Selenium nanoparticles. Selenite has been proven to have antioxidant activity and is being used as chemoprevention agent in cancer diagnosis but same time it is toxic also. Elemental Selenium i.e. Selenium nanoparticles are less toxic form of selenium.

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Mobilization of Selenite by Ralstonia metallidurans CH34

Applied and Environmental Microbiology ◽

10.1128/aem.67.2.769-773.2001 ◽

2001 ◽

Vol 67 (2) ◽

pp. 769-773 ◽

Cited By ~ 73

Author(s):

Murielle Roux ◽

Géraldine Sarret ◽

Isabelle Pignot-Paintrand ◽

Marc Fontecave ◽

Jacques Coves

Keyword(s):

Alcaligenes Eutrophus ◽

Culture Conditions ◽

Lag Phase ◽

Elemental Selenium ◽

Kinetics Analysis ◽

X Ray ◽

Polluted Sites ◽

Ralstonia Metallidurans ◽

X Ray Absorption ◽

Bioremediation Processes

ABSTRACT Ralstonia metallidurans CH34 (formerlyAlcaligenes eutrophus CH34) is a soil bacterium characteristic of metal-contaminated biotopes, as it is able to grow in the presence of a variety of heavy metals. R. metalliduransCH34 is reported now to resist up to 6 mM selenite and to reduce selenite to elemental red selenium as shown by extended X-ray absorption fine-structure analysis. Growth kinetics analysis suggests an adaptation of the cells to the selenite stress during the lag-phase period. Depending on the culture conditions, the medium can be completely depleted of selenite. Selenium accumulates essentially in the cytoplasm as judged from electron microscopy and energy-dispersive X-ray analysis. Elemental selenium, highly insoluble, represents a nontoxic storage form for the bacterium. The ability of R. metallidurans CH34 to reduce large amounts of selenite may be of interest for bioremediation processes targeting selenite-polluted sites.

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Stable isotope fractionation by Clostridium pasteurianum. 5. Effect of SeO42− on the physiology and associated sulfur isotope fractionation during SO32− and SO42− reductions

Canadian Journal of Microbiology ◽

10.1139/m82-048 ◽

1982 ◽

Vol 28 (3) ◽

pp. 325-333 ◽

Cited By ~ 1

Author(s):

G. I. Harrison ◽

E. J. Laishley ◽

H. R. Krouse

Keyword(s):

Stationary Phase ◽

Isotope Fractionation ◽

Sulfur Isotope ◽

Reductase Activity ◽

Clostridium Pasteurianum ◽

Elemental Selenium ◽

Whole Cells ◽

Stable Isotope Fractionation ◽

Sulfur Isotope Fractionation ◽

Inverse Isotope Effect

The addition of 1 mM SeO42− significantly affected the physiology and metabolism of Clostridium pasteurianum growing on SO42− in the following ways: (1) the generation time was increased, essentially producing a biphasic growth curve, (2) cells became elongated and chains formed, (3) no H2S was liberated during the stationary phase, (4) assimilatory SO32− reductase activity was decreased, (5) ferredoxin levels decreased by a factor of 4. The effects of 1 mM SeO42− on Clostridium pasteurianum growing on SO32− were comparatively minor.H2S evolution in the stationary phase decreased by a factor of 2 and the δ34S maximum in the inverse isotope effect pattern occurred at a slightly lower percent H2S evolution. The deleterious effects of SeO42− addition were less pronounced than those associated with SeO32− addition. SeO32− but not SeO42− was reduced to elemental selenium by both whole cells and crude extracts.

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