ChemInform Abstract: PYRYLIUM-MEDIATED TRANSFORMATIONS OF NATURAL PRODUCTS. PART 7. DISPLACEMENT OF THE N-SUBSTITUENTS OF PYRIDINIUM IONS IN AQUEOUS SOLUTION: REPLACEMENT OF THE Ω-AMINO GROUP OF LYSINE, AND OF THE TERMINAL AMINO GROUP OF GLYCYLGLYCINE

1984 ◽  
Vol 15 (34) ◽  
Author(s):  
A. R. KATRITZKY ◽  
Y.-K. YANG
Keyword(s):  
Aqueous Solution ◽  
Natural Products ◽  
Amino Group ◽  
Terminal Amino ◽  
Pyridinium Ions

Reaction of metallic nitrilotriacetates with histamine

1969 ◽  
Vol 47 (8) ◽  
pp. 1269-1273 ◽  
Author(s):  
A. L. Beauchamp ◽  
J. Israeli ◽  
H. Saulnier
Keyword(s):  
Potentiometric Titration ◽  
Formation Constants ◽  
Amino Group ◽  
Mixed Complex ◽  
Ph Values ◽  
Titration Curves ◽  
Terminal Amino ◽  
Complex Ion

Cu(II), Ni(II), Co(II), and Zn(II) nitrilotriacetates (MeX−) react with histamine nitrate (LH+) to form a protonated mixed complex MeXLH where the metal appears to be bound only to the tertiary imidazolic nitrogen of histaminium ion. At higher pH values the proton dissociates to yield a mixed complex ion MeXL− in which both the imidazolic nitrogen and the terminal amino group are coordinated. The formation constants of these species were calculated from the potentiometric titration curves.

Synthesis of three Salmonella epitopes for biosensor studies of carbohydrate–antibody interactions

2002 ◽  
Vol 80 (8) ◽  
pp. 1131-1140 ◽  
Author(s):  
Henry N Yu ◽  
Chang-Chun Ling ◽  
David R Bundle
Keyword(s):  
Key Words ◽  
Self Assembled Monolayers ◽  
Antigenic Determinants ◽  
Amino Group ◽  
Assembled Monolayers ◽  
Construction Of Self ◽  
Terminal Amino ◽  
Salmonella Serotypes ◽  
O Antigens ◽  
Antibody Interactions

Disaccharides 1-3 corresponding to the antigenic determinants of Salmonella serotypes A, B, and D1 were synthesized in a form suited for use in biosensors. The disaccharide determinants each contain a unique 3,6-dideoxyhexose, namely abequose (3,6-dideoxy-D-xylo-hexose), paratose (3,6-dideoxy-D-ribohexose), and tyvelose (3,6-dideoxy-D-arabino-hexose), are α-linked to the 3-position of D-mannopyranose. The disaccharides were further derivatized with a linear aglycon that has a terminal amino group, and can be readily coupled to pertinent chains carrying a terminal thiol for the construction of self-assembled monolayers (SAMs). Efficient routes that employed a single 3,6-dideoxygenation step were developed for the synthesis of paratoside 15 and tyveloside 22.Key words: Salmonella O-antigens, lipopolysaccharide, abequose, paratose, tyvelose, 3,6-dideoxyhexose, deoxygenation, glycoside tethers, immobilization via pentenyl glycosides.

Heats of solution of gaseous anilinium and pyridinium ions in water and intrinsic basicities in aqueous solution

1973 ◽  
Vol 95 (11) ◽  
pp. 3811-3812 ◽  
Author(s):  
R. W. Taft ◽  
M. Taagepera ◽  
K. D. Summerhays ◽  
J. Mitsky
Keyword(s):  
Aqueous Solution ◽  
Heats Of Solution ◽  
Pyridinium Ions

scholarly journals New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 545
Author(s):  
Niccolò Chiaramonte ◽  
Alessio Gabellini ◽  
Andrea Angeli ◽  
Gianluca Bartolucci ◽  
Laura Braconi ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Imidazole Ring ◽  
Aliphatic Chain ◽  
Amino Group ◽  
Carbonic Anhydrase I ◽  
Terminal Amino ◽  
Human Carbonic Anhydrase ◽  
New Compounds ◽  
Related Compounds ◽  
Micromolar Range

A series of histamine (HST)-related compounds were synthesized and tested for their activating properties on five physiologically relevant human Carbonic Anhydrase (hCA) isoforms (I, II, Va, VII and XIII). The imidazole ring of HST was replaced with different 5-membered heterocycles and the length of the aliphatic chain was varied. For the most interesting compounds some modifications on the terminal amino group were also performed. The most sensitive isoform to activation was hCA I (KA values in the low micromolar range), but surprisingly none of the new compounds displayed activity on hCA II. Some derivatives (1, 3a and 22) displayed an interesting selectivity for activating hCA I over hCA II, Va, VII and XIII.

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