ChemInform Abstract: Synthesis and Pharmacological Activities of Novel Bicyclic Thiazoline Derivatives as Hepatoprotective Agents. Part 2. (7-Alkoxycarbonyl-2,3, 5,6-tetrahydropyrrolo(2,1-b)thiazol-3-ylidene)acetamide Derivatives.

ABSTRACT Fractionation of monkey pituitary glands gave an oxytocin fraction in low yield which showed a counter-current distribution coefficient equivalent to that obtained with oxytocin from other species. Fractionation and chromatography of monkey vasopressin on carboxymethyl cellulose gave arginine-vasopressin of 60% purity, based on amino acid analysis and specific activity. Counter-current distribution on a small scale gave arginine-vasopressin of 89% purity. Reports by others that monkey pituitary glands contain arginine-vasopressin, based on pharmacological activities, are substantiated by the chemical data presented here.

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Antipyretic Activity of the Root Extracts of Xylocarpus

International Journal of Research in Phytochemistry and Pharmacology ◽

10.26452/ijrpp.v9i3.1333 ◽

2019 ◽

Vol 9 (3) ◽

pp. 35-38

Author(s):

Ganesh Kumar Y ◽

Pranitha D ◽

Phaneendra D ◽

Madhava Reddy Ch

Keyword(s):

Mechanisms Of Action ◽

Prostaglandin Synthesis ◽

The Body ◽

Human Race ◽

Pharmacological Activities ◽

Standard Drug ◽

Root Extracts ◽

Antipyretic Activity ◽

Inhibition Of Prostaglandin Synthesis ◽

Elevated Body Temperature

Various types of conditions exist in the body that causes fever and pain. Drugs that are used to treat fever are called antipyretics, and those are usually prescribed to treat elevated body temperature. But those drugs result in many other side effects like ulcers, perforations, bleedings and obstructions, which make their use questionable and limiting. Medicinal plants are used in the treatment of diseases from the starting of the human race and the process; they had been subjected to rigorous investigations and tests to establish a scientific proof and validation of the various pharmacological activities and their respective mechanisms of action in treating the herbs. Considering the anti-inflammatory properties of the plant, Xylocarpus mekongesis was investigated for its antipyretic activity in yeast method and 3doses out of which 00mg/kg body weight showed a better activity compared to the standard drug and other extracts too. The mechanism of action was similar to the paracetamol action that is inhibition of prostaglandin synthesis.

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A REVIEW ON RECENT ADVANCES IN CHEMISTRY, SYNTHESIS AND BIOLOGICAL APPLICATIONS OF ISATIN DERIVATIVES

Journal of Applied Pharmaceutical Sciences and Research ◽

10.31069/japsr.v1i2.13063 ◽

2018 ◽

pp. 16-22

Author(s):

Shukla PK ◽

Singh MP ◽

Patel R

Keyword(s):

Heterocyclic Compounds ◽

Biologically Active ◽

Biological Applications ◽

Plant Origin ◽

Recent Past ◽

Pharmacological Activities ◽

Naturally Occurring ◽

Recent Advances ◽

Biological Aspects ◽

Isatin Derivatives

Indole and its derivatives have engaged a unique place in the chemistry of nitrogen heterocyclic compounds. The recognition of the plant growthhormone, heteroauxin, the significant amino acids, tryptamine & tryptophan and anti-inflammatory drug, indomethacine are the imperativederivatives of indole which have added stimulus to this review work. Isatin (1H-indole-2,3-dione), an indole derivative of plant origin. Althoughit is a naturally occurring compound, but was synthesized by Erdmann and Laurent in 1840 before it was found in nature. Isatin is a versatileprecursor for many biologically active molecules and its diversified nature makes it a versatile substrate for further modifications. It is concernedin many pharmacological activities like anti-malarial, antiviral, anti-allergic, antimicrobial etc; isatin and its derivatives have been also found todemonstrate promising outcomes against various cancer cell lines. This review provides a brief overview on the recent advances and futureperspectives on chemistry and biological aspects of isatin and its derivatives reported in the recent past.

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Pharmacological Activities and Chemical Constituents and of Bryonia Dioica L.:A Review

Indian Journal of Public Health Research & Development ◽

10.37506/v11/i2/2020/ijphrd/195157 ◽

2020 ◽

Vol 11 (2) ◽

pp. 2189

Author(s):

Thamer Mouhi Jasiem ◽

Rasha Eldalawy ◽

Zahraa Abdul Elah Alnaqqash

Keyword(s):

Chemical Constituents ◽

Pharmacological Activities ◽

Bryonia Dioica

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A Comprehensive Review on the Therapeutic Versatility of Imidazo [2,1-b]thiazoles

Current Medicinal Chemistry ◽

10.2174/0929867326666190729152440 ◽

2020 ◽

Vol 27 (40) ◽

pp. 6864-6887 ◽

Cited By ~ 1

Author(s):

Mohd Adil Shareef ◽

Irfan Khan ◽

Bathini Nagendra Babu ◽

Ahmed Kamal

Keyword(s):

Literature Review ◽

Medicinal Chemistry ◽

Therapeutic Agents ◽

Present Review ◽

Thiazole Derivatives ◽

Pharmacological Activities ◽

Comprehensive Review ◽

Derivatives Of

Background:: Imidazo[2,1-b]thiazole, a well-known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents. Objective:: To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness. Method:: Thorough literature review of all relevant papers and patents was conducted. Conclusion:: The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.

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