ChemInform Abstract: Recent Advances in Asymmetric Catalysis. Synthetic Applications to Biologically Active Compounds

ChemInform ◽  
2010 ◽  
Vol 32 (42) ◽  
pp. no-no
Author(s):  
Jean Pierre Genet ◽  
Angela Marinetti ◽  
Virginie Ratovelomanana-Vidal
Keyword(s):  
Asymmetric Catalysis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Recent Advances

Recent Advances in the Green Synthesis of Heterocycles: From Building Blocks to Biologically Active Compounds

2021 ◽  
Vol 18 ◽  
Author(s):  
Christian Schäfer ◽  
Hyejin Cho ◽  
Bernadett Vlocskó ◽  
Guoshu Xie ◽  
Béla Török
Keyword(s):  
Green Synthesis ◽  
Building Blocks ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Active Compounds ◽  
Aromatic Heterocycles ◽  
High Interest ◽  
Recent Advances ◽  
Benign Synthesis

: Recent advances in the environmentally benign synthesis of common heterocycles are described. This account features three main parts; the preparation of non-aromatic heterocycles, one-ring aromatic heterocycles and their condensed analogs. Due to the great variety of and high interest in these compounds, this work focuses on providing representative examples of the preparation of the target compounds.

scholarly journals Organocatalytic atroposelective synthesis of axially chiral styrenes

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Sheng-Cai Zheng ◽  
San Wu ◽  
Qinghai Zhou ◽  
Lung Wa Chung ◽  
Liu Ye ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Addition Reaction ◽  
Building Blocks ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Chiral Compounds ◽  
Axially Chiral ◽  
Potential Applications ◽  
Styrene Derivatives

Abstract Axially chiral compounds are widespread in biologically active compounds and are useful chiral ligands or organocatalysts in asymmetric catalysis. It is well-known that styrenes are one of the most abundant and principal feedstocks and thus represent excellent prospective building blocks for chemical synthesis. Driven by the development of atroposelective synthesis of axially chiral styrene derivatives, we discovered herein the asymmetric organocatalytic approach via direct Michael addition reaction of substituted diones/ketone esters/malononitrile to alkynals. The axially chiral styrene compounds were produced with good chemical yields, enantioselectivities and almost complete E/Z-selectivities through a secondary amine-catalysed iminium activation strategy under mild conditions. Such structural motifs are important precursors for further transformations into biologically active compounds and synthetic useful intermediates and may have potential applications in asymmetric synthesis as olefin ligands or organocatalysts.

scholarly journals Electrophilic Iodination of Organic Compounds Using Elemental Iodine or Iodides: Recent Advances 2008–2021: Part I

Compounds ◽  
2022 ◽  
Vol 2 (1) ◽  
pp. 3-24
Author(s):  
Njomza Ajvazi ◽  
Stojan Stavber
Keyword(s):  
Organic Chemistry ◽  
Organic Compounds ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Present Review ◽  
Active Compounds ◽  
Synthetic Organic Chemistry ◽  
Recent Advances ◽  
Elemental Iodine

The iodination of organic compounds is of great importance in synthetic organic chemistry. It opens comprehensive approaches for the synthesis of various biologically active compounds. The recent advances in iodination of organic compounds using elemental iodine or iodides, covering the last thirteen years, are the objective of the present review.

Recent advances in the catalytic synthesis of 3-aminooxindoles: an update

2020 ◽  
Vol 18 (25) ◽  
pp. 4692-4708 ◽  
Author(s):  
Jasneet Kaur ◽  
Banni Preet Kaur ◽  
Swapandeep Singh Chimni
Keyword(s):  
Natural Products ◽  
Catalytic Synthesis ◽  
Biologically Active Compounds ◽  
Core Structure ◽  
Biologically Active ◽  
Active Compounds ◽  
The Core ◽  
Recent Advances

3-Substituted-3-aminooxindoles are versatile scaffolds and these motifs constitute the core structure of number of natural products and biologically active compounds.

scholarly journals Modular Chiral N-Heterocyclic Carbene Ligands for the Nickel-Catalyzed Enantioselective C–H Functionalization of Heterocycles

2020 ◽  
Vol 74 (4) ◽  
pp. 278-284
Author(s):  
Johannes Diesel ◽  
Nicolai Cramer
Keyword(s):  
Transition Metals ◽  
Asymmetric Catalysis ◽  
Heterocyclic Carbenes ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Carbene Ligands ◽  
Active Compounds ◽  
Flexible Ligand ◽  
Mild Conditions ◽  
Bicyclic Compounds

N-Heterocyclic carbenes (NHCs) are the ligands of choice in a large variety of transformations entailing different transition metals. However, the number and variety of chiral NHCs suitable as stereo-controlling ligands in asymmetric catalysis remains limited. Herein we highlight the introduction of a modular NHC ligand family, consisting of a chiral version of the widely used IPr ligand. These chiral NHC ligands were applied in the nickel-catalyzed enantioselective C–H functionalization of N-heterocycles. Nickel-NHC catalysis unlocked the stereoselective C–H annulation of 2- and 4-pyridones, delivering fused bicyclic compounds found in many biologically active compounds. Applying a bulky, yet flexible ligand scaffold enabled the highly enantioselective C–H functionalization of pyridones under mild conditions. The introduction of a bulky chiral SIPr analogue enabled the nickel-catalyzed enantioselective C–H functionalization of indoles, yielding valuable tetrahydropyridoindoles. Additionally, pyrrolopyridines, pyrrolopyrimidines and pyrroles were efficiently functionalized, delivering chiral annulated azoles.

Catalytic, Enantioselective Diamination of Alkenes

Synthesis ◽  
2021 ◽  
Author(s):  
Scott E. Denmark ◽  
Zhong-Lin Tao
Keyword(s):  
Asymmetric Synthesis ◽  
Reaction Mechanisms ◽  
Short Review ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Recent Advances ◽  
Vicinal Diamines

AbstractEnantioselective diamination of alkenes represents one of the most straightforward methods to access enantioenriched, vicinal diamines, which are not only frequently encountered in biologically active compounds, but also have broad applications in asymmetric synthesis. Although the analogous dihydroxylation of olefins is well-established, the development of enantioselective olefin diamination lags far behind. Nevertheless, several successful methods have been developed that operate by different reaction mechanisms, including a cycloaddition pathway, a two-electron redox pathway, and a radical pathway. This short review summarizes recent advances and identifies limitations, with the aim of inspiring further developments in this area.1 Introduction2 Cycloaddition Pathway3 Two-Electron Redox Pathway3.1 Pd(0)/Pd(II) Diamination3.2 Pd(II)/Pd(IV) Diamination3.3 I(I)/I(III) Diamination3.4 Se(II)/Se(IV) Diamination4 One-Electron Radical Pathway4.1 Cu-Catalyzed Diamination4.2 Fe-Catalyzed Diamination5 Summary and Outlook

scholarly journals Advances in deep eutectic solvents and water: applications in metal- and biocatalyzed processes, in the synthesis of APIs, and other biologically active compounds

2021 ◽  
Author(s):  
Luciana Cicco ◽  
Giuseppe Dilauro ◽  
Filippo Maria Perna ◽  
Paola Vitale ◽  
Vito Capriati
Keyword(s):  
Deep Eutectic Solvents ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Recent Advances ◽  
Environmentally Responsible

This review highlights recent advances in metal- and biocatalyzed transformations, in the synthesis of APIs and other biologically active compounds, when employing deep eutectic solvents and water as environmentally responsible solvents.

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