ChemInform Abstract: New Bisabolane Sesquiterpenes from the Rhizomes of Curcuma xanthorrhiza Roxb. and Their Inhibitory Effects on UVB-Induced MMP-1 Expression in Human Keratinocytes.

A new guaiane sesquiterpene, (1 R,4 S,5 S,10 R)-10-methyl guaianediol (1), along with five known compounds, 10-methylalismoxide (2), (+)-alismoxide (3), isozedoarondiol (4), zedoarondiol (5), and zedoalactone B (6), were isolated from the rhizomes of Curcuma xanthorrhiza Roxb. Compounds 1-6 were isolated from this plant for the first time. Chemical structures were determined using nuclear magnetic resonance (NMR), electron ionization mass spectrometry (EI/MS), polarimetry, circular dichroism (CD), and infrared spectroscopy (IR). Compounds 3 and 4 decreased MMP-1 expression in UVB-treated human keratinocytes by about 8.9-fold and 7.6-fold at the mRNA level, and by about 9.2-fold and 6.6-fold at the protein level, respectively. Results indicate that the isolated compounds have anti-aging effects by inhibiting MMP-1 expression in skin cells.

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Inhibitory Effects of Ecklonia cava Ethanol Extracts against TNF-α/IFN-γ-Induced Inflammation in Human Keratinocytes

Journal of Chitin and Chitosan ◽

10.17642/jcc.22.2.3 ◽

2017 ◽

Vol 22 (2) ◽

pp. 82-88 ◽

Cited By ~ 1

Author(s):

Nalae Kang ◽

Eui Jeong Han ◽

Soo Yeon Park ◽

Youngheun Jee ◽

You-Jin Jeon ◽

...

Keyword(s):

Human Keratinocytes ◽

Ecklonia Cava ◽

Inhibitory Effects ◽

Tnf Α ◽

Ifn Γ ◽

Ethanol Extracts

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New Bisabolane Sesquiterpenes from the Rhizomes ofCurcuma xanthorrhizaRoxb. and Their Inhibitory Effects on UVB-Induced MMP-1 Expression in Human Keratinocytes

Helvetica Chimica Acta ◽

10.1002/hlca.201300372 ◽

2014 ◽

Vol 97 (3) ◽

pp. 438-446 ◽

Cited By ~ 9

Author(s):

Ji-Hae Park ◽

Ye-Jin Jung ◽

Mohamed Antar Aziz Mohamed ◽

Tae Hoon Lee ◽

Chang-Ho Lee ◽

...

Keyword(s):

Human Keratinocytes ◽

Inhibitory Effects

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Inhibitory effects of skin permeable glucitol-core containing gallotannins from red maple leaves on elastase and their protective effects on human keratinocytes

Journal of Functional Foods ◽

10.1016/j.jff.2020.104208 ◽

2020 ◽

Vol 75 ◽

pp. 104208

Author(s):

Chang Liu ◽

Yiming Xu ◽

Riley D. Kirk ◽

Huifang Li ◽

Dongli Li ◽

...

Keyword(s):

Human Keratinocytes ◽

Protective Effects ◽

Red Maple ◽

Inhibitory Effects ◽

Maple Leaves

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Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes

Molecular Medicine Reports ◽

10.3892/mmr.2014.3074 ◽

2014 ◽

Vol 11 (4) ◽

pp. 3143-3147 ◽

Cited By ~ 10

Author(s):

LYSANN MICHAELA MEHLIG ◽

CLAUDIA GARVE ◽

JOSEPHINE TABEA TAUER ◽

MEINOLF SUTTORP ◽

ANDREA BAUER

Keyword(s):

Vitamin D3 ◽

Human Keratinocytes ◽

Inhibitory Effects

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Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT

International Journal of Immunopathology and Pharmacology ◽

10.1177/2058738418821837 ◽

2019 ◽

Vol 33 ◽

pp. 205873841882183 ◽

Cited By ~ 2

Author(s):

Jun Wang ◽

Guanzhi Chen ◽

Tongxin Shi ◽

Yingying Wang ◽

Chengfei Guan

Keyword(s):

Cell Viability ◽

Lichen Planus ◽

Inflammatory Cytokines ◽

Cell Injury ◽

Hacat Cell ◽

Human Keratinocytes ◽

Hacat Cells ◽

Protective Effects ◽

Inhibitory Effects ◽

Inflammatory Injury

Cutaneous lichen planus (CLP) is an autoimmune disease. Angelica polysaccharide (AP) has been found to exert immunomodulation activity. In this study, we explored the roles of AP in lipopolysaccharide (LPS)-induced inflammatory injury of human keratinocytes (HaCaT cells), as well as the underlying mechanisms. LPS-induced cell injury was evaluated by alterations of cell viability, apoptosis, and expressions of proteins associated with apoptosis and inflammatory cytokines. Then, the protective effects of AP on LPS-induced cell injury were assessed. The protein expressions of sirtuin 1 (SIRT1) and key kinases in the Nrf2/HO-1 and nuclear factor κB (NF-κB) pathways were measured using western blotting. SIRT1 knockdown and overexpression were used to analyze whether AP affected HaCaT cells through regulating SIRT1. Finally, the possible inhibitory effects of AP on cell injury after LPS treatment were also evaluated. We found that LPS reduced HaCaT cell viability, enhanced apoptosis, and induced release of inflammatory cytokines. AP alleviated LPS-induced HaCaT cell inflammatory injury. The expression of SIRT1 was enhanced after AP treatment. AP activated Nrf2/HO-1 pathway while inhibited NF-κB pathway in HaCaT cells. The protective effects of AP on LPS-induced HaCaT cell injury were reversed by SIRT1 knockdown. Dysregulation of SIRT1 altered the activation of Nrf2/HO-1 and NF-κB pathways in LPS-treated HaCaT cells. Furthermore, AP also exerted inhibitory effects on HaCaT cell injury after LPS stimulation. In conclusion, AP could alleviate LPS-induced inflammatory injury of HaCaT cells through upregulating SIRT1 expression and then activating Nrf2/HO-1 pathway but inactivating NF-κB pathway. This study provided a possible therapeutic strategy for clinical CLP treatments.

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