ChemInform Abstract: Synthetic Approaches to Functional Derivatives of Cycl[3.2.2]azine-1,2-dicarboxylic Acid - Perspective Building Blocks for π-Extended Macrocyclic Compounds

ChemInform ◽  
2015 ◽  
Vol 46 (37) ◽  
pp. no-no
Author(s):  
Fedor E. Zhurkin ◽  
Victor E. Pushkarev ◽  
Larisa G. Tomilova
Keyword(s):  
Dicarboxylic Acid ◽  
Building Blocks ◽  
Macrocyclic Compounds ◽  
Functional Derivatives ◽  
Synthetic Approaches ◽  
Derivatives Of

Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

2019 ◽  
Vol 16 (7) ◽  
pp. 653-688 ◽  
Author(s):  
Leena Kumari ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Daman Pandey ◽  
Mohammad Shahar Yar ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Vital Role ◽  
Review Of Literature ◽  
Drug Discovery Process ◽  
Active Compounds ◽  
Lead Compounds ◽  
Synthetic Approaches ◽  
Derivatives Of

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

Functional derivatives of (bi)phenyl-substituted carbazoles as building blocks for electro-active polymers

2010 ◽  
Vol 70 (7) ◽  
pp. 477-481 ◽  
Author(s):  
S. Lengvinaite ◽  
J.V. Grazulevicius ◽  
S. Grigalevicius ◽  
B. Zhang ◽  
Z. Xie
Keyword(s):  
Building Blocks ◽  
Functional Derivatives ◽  
Derivatives Of

Synthesis of aryl-substituted polyisobutylenes as precursors for ligands for greener, phase-selectively soluble catalysts

2009 ◽  
Vol 81 (11) ◽  
pp. 1981-1990 ◽  
Author(s):  
David E. Bergbreiter ◽  
Chris Hobbs ◽  
Jianhua Tian ◽  
Hisao Koizumi ◽  
Haw-Lih Su ◽  
...  
Keyword(s):  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Homogeneous Catalysts ◽  
Functional Derivatives ◽  
Potential Problems ◽  
Ligand Precursors ◽  
Synthetic Approaches ◽  
Derivatives Of

General synthetic approaches to functional derivatives of polyisobutylene (PIB) that contain arene groups that can be used as catalysts or as precursors to catalyst ligands are discussed. The emphasis is on reactions that use commercially available terminally functionalized PIB derivatives as starting materials. Both successful and unsuccessful electrophilic aromatic substitution processes are described, and potential problems of this process and ways to circumvent the problem of depolymerization of the intermediate polyisobutyl cation in substitutions of less reactive arenes are detailed. Examples that lead to polyisobutyl-containing arenes that are known and potentially useful as ligands or ligand precursors for greener homogeneous catalysts that are phase-selectively soluble and recoverable in heptane are emphasized.

SYNTHESIS OF N-HYDROXYINDOLES

2017 ◽  
Vol 60 (4) ◽  
pp. 4 ◽  
Author(s):  
Zhanna V. Chirkova
Keyword(s):  
Noble Metals ◽  
Dicarboxylic Acids ◽  
Building Blocks ◽  
Monoamine Oxidase A ◽  
Biologically Active ◽  
Synthetic Methods ◽  
Titanium Chloride ◽  
Functional Derivatives ◽  
Derivatives Of ◽  
Treat Breast Cancer

The basic synthetic methods for obtaining N-hydroxyindoles were studied. The first method is intramolecular reductive cyclization of ortho-substituted nitroaromatic compounds by various reducing agents. Nitrophenyl acetaldehydes (synthesis by Acheson), N,N-disubstituted amino-2-nitrostyrenes (synthesis by Somei), ortho-nitroketoetheres of different structure or 1-(o-nitroarene)-1-cyanoalkylnitroketones, ortho-nitrophenylacetonitriles were used as substrates for the synthesis of N-hydroxyindoles. Titanium chloride (III), zinc in THF solution of ammonium chloride or in acetic acid, stannous chloride in ethanolic HCl, and hydrogen with application of catalytic agent on basis of noble metals (platinum, palladium) were used as reduction agents. The second method is a [3+2]-cycloaddition with nitrozoaromatic compounds to alkynes or deoxygenation ortho-nitro substituted aromatic compounds with subsequent intramolecular cyclization. The third method is catalytic oxidation of 2,3-dihydroindoles or different indoles by concentrated hydrogen peroxide with application of of tungstate sodium as catalyst. We attended special attention to synthesis of functional derivatives of N-hydroxyindole-5,6-dicarboxylic acids because these compounds were synthesized from commercially available basic materials using well known synthetic methods and without using expensive catalysts. Indoles of various designs were synthesized. They may be building blocks for the synthesis of biologically active substances, phthalocyanines of different structures having mesomorphic and catalytic properties. Compounds of this class of heterocycles were found among many natural products and they can be used as therapeutic agents, for example, as inhibitors of human lactate dehydrogenase of isoforms 5, selective inhibitors of monoamine oxidase A and B, and N-methoxyindole can be used to treat breast cancer. For citation:Chirkova Zh.V. Synthesis of N-hydroxyindoles. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 4. P. 4-20.

scholarly journals Synthetic approaches to 2,5-bis(hydroxymethyl)furan (BHMF): a stable bio-based diol

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Fabio Aricò
Keyword(s):  
Dicarboxylic Acid ◽  
Building Blocks ◽  
Comprehensive Overview ◽  
Future Developments ◽  
Synthetic Approaches ◽  
First Time

Abstract Biorefinery is defined as a sustainable process where biomass is converted in a spectrum of marketable products and fuels. In this view, C6 furan-based compounds, usually referred as furanics, have been extensively investigated as aromatic promising building blocks from renewables. 5-Hydroxymethylfurfural (HMF) and 2,5-furan dicarboxylic acid (FDCA) are well known examples of furanics whose syntheses and applications have been extensively reviewed in the literature. Herein for the first time it is reported a comprehensive overview on the synthetic procedures to another bio-derived furan compounds, i.e. 2,5-bis(hydroxymethyl)furan (BHMF), a stable bio-based diol with numerous applications as monomer for bio-materials and fuels. Advantages and limitations of the different synthetic approaches are addressed, as well as possible future developments to render this compound part of the biorefinery market.

Functional Derivatives of Sterically Hindered Amines. Polyalkylpiperidine Diesters

1995 ◽  
Vol 60 (9) ◽  
pp. 1529-1535 ◽  
Author(s):  
František Vašš ◽  
Jozef Lustoň
Keyword(s):  
Dicarboxylic Acid ◽  
Nucleophilic Addition ◽  
Dicarboxylic Acids ◽  
Amino Derivative ◽  
Replacement Reaction ◽  
Structural Units ◽  
Functional Derivatives ◽  
Acid Catalyzed ◽  
Hindered Amines ◽  
Derivatives Of

Several diesters of dicarboxylic acids with pendant polyalkylpiperidine structural units were prepared from α-bromo and α,α'-dibromo substituted aliphatic dicarboxylic acid diesters by a nucleophilic replacement reaction with 2,2,6,6-tetramethyl-4-hydroxypiperidine, 1,2,2,6,6-pentamethyl-4-hydroxypiperidine, and 2,2,6,6-tetramethyl-4-aminopiperidine, by a nucleophilic addition of amino derivative to the α,β-unsaturated dicarboxylic acid diester and by an acid catalyzed condensation of 2,2,6,6-tetramethyl-4-oxopiperidine with diethyl bis(hydroxymethyl)malonate.

The Coarse Scale Velocity

2017 ◽  
Author(s):  
Philip Isett
Keyword(s):  
Velocity Field ◽  
Building Blocks ◽  
Coarse Scale ◽  
Divergence Equation ◽  
Higher Derivatives ◽  
Order Of Magnitude ◽  
Derivatives Of

This chapter deals with the coarse scale velocity. It begins the proof of Lemma (10.1) by choosing a double mollification for the velocity field. Here ∈ᵥ is taken to be as large as possible so that higher derivatives of velement are less costly, and each vsubscript Element has frequency smaller than λ‎ so elementv⁻¹ must be smaller than λ‎ in order of magnitude. Each derivative of vsubscript Element up to order L costs a factor of Ξ‎. The chapter proceeds by describing the basic building blocks of the construction, the choice of elementv and the parametrix expansion for the divergence equation.

ChemInform Abstract: BROMINATION OF FUNCTIONAL DERIVATIVES OF SOME VINYLACETYLENE HYDROCARBONS AND SILICON HYDROCARBONS

1976 ◽  
Vol 7 (44) ◽  
pp. no-no
Author(s):  
T. R. BORONOEVA ◽  
N. N. BELYAEV ◽  
M. D. STADNICHUK ◽  
A. A. PETROV
Keyword(s):  
Functional Derivatives ◽  
Derivatives Of

scholarly journals Core-Substituted Naphthalene-diimides (cNDI) and Related Derivatives: Versatile Scaffold for Supramolecular Assembly and Functional Materials

2021 ◽  
Author(s):  
Anurag Mukherjee ◽  
Suhrit Ghosh
Keyword(s):  
Photophysical Properties ◽  
Supramolecular Assembly ◽  
Functional Materials ◽  
Building Blocks ◽  
Short Review ◽  
Molecular Engineering ◽  
Organic Optoelectronics ◽  
Naphthalene Diimide ◽  
Naphthalene Diimides ◽  
Derivatives Of

Naphthalene-diimide (NDI) derived building blocks have been explored extensively for supramolecular assembly as they exhibit attractive photophysical properties, suitable for applications in organic optoelectronics. Core-substituted derivatives of the NDI chromophore (cNDI) differ significantly from the parent NDI dye in terms of optical and redox properties. Adequate molecular engineering opportunities and substitution-dependent tunable optoelectronic properties make cNDI derivatives highly promising candidates for supramolecular assembly and functional material. This short review discusses recent development in the area of functional supramolecular assemblies based on cNDIs and related molecules.

Sign in / Sign up

Export Citation Format

Share Document