The tooling and fixture play important roles in manufacturing and production. It affects both product quality and quantity. Better tooling and fixture can also promote cost-effective manufacturing process. This paper introduces a new type of universal clamping mechanism based on computer-aided 3D modeling, engineering structural analysis, and prototype testing. It can be applied to easily and reliably clamp different geometrical shape of work pieces per user requirements. This new clamping mechanism, with less moving components, can assist manufacturing industry for high speed production, easy part handling, precise clamping, and lower tooling cost. Keywords: Computer-aided design, automated production, 3D modeling, cost-effective, high speed manufacturing, engineering analysis, optimization, efficient;
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