Discovery of Potent, Orally Bioavailable Small-Molecule Inhibitors of the Human CCR2 Receptor

ChemMedChem ◽

10.1002/cmdc.200700276 ◽

2008 ◽

Vol 3 (4) ◽

pp. 660-669 ◽

Author(s):

Julien Doyon ◽

Erwin Coesemans ◽

Staf Boeckx ◽

Mieke Buntinx ◽

Bart Hermans ◽

...

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Orally Bioavailable

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Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Journal of Medicinal Chemistry ◽

10.1021/jm501436m ◽

2015 ◽

Vol 58 (4) ◽

pp. 1717-1735 ◽

Author(s):

Aurélie Mallinger ◽

Simon Crumpler ◽

Mark Pichowicz ◽

Dennis Waalboer ◽

Mark Stubbs ◽

...

Keyword(s):

Wnt Signaling ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

A Cell ◽

Orally Bioavailable

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Abstract 53: Discovery of novel potent and orally bioavailable small-molecule inhibitors of ENPP1 to stabilize cGAMP and ATP in the tumor microenvironment and boost anti-tumor immunity

10.1158/1538-7445.am2021-53 ◽

2021 ◽

Author(s):

Matthias Versele ◽

Javier del Pino Garcia ◽

Ilse Vandecaetsbeek ◽

Karolien Castermans ◽

Ranie Kellens ◽

...

Keyword(s):

Tumor Microenvironment ◽

Tumor Immunity ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Orally Bioavailable

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b01407 ◽

2018 ◽

Vol 61 (23) ◽

pp. 10767-10792 ◽

Author(s):

Bohdan Waszkowycz ◽

Kate M. Smith ◽

Alison E. McGonagle ◽

Allan M. Jordan ◽

Ben Acton ◽

...

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Dna Damage Repair ◽

Repair Enzyme ◽

Damage Repair ◽

Orally Bioavailable

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Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery

MedChemComm ◽

10.1039/c3md00280b ◽

2014 ◽

Vol 5 (2) ◽

pp. 134-141 ◽

Author(s):

Gordon Saxty ◽

David Norton ◽

Karen Affleck ◽

Dave Clapham ◽

Anne Cleasby ◽

...

Keyword(s):

Drug Discovery ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Prostaglandin D2 ◽

X Ray ◽

Prostaglandin D2 Synthase ◽

Orally Bioavailable ◽

Fragment Based Drug Discovery

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From molecular diagnostics to molecular targeted therapy with natural product small molecule inhibitors in oral squamous cell carcinoma

Planta Medica ◽

10.1055/s-2007-986722 ◽

2007 ◽

Vol 73 (09) ◽

Author(s):

VB Konkimalla ◽

VL Suhas ◽

NR Chandra ◽

E Gebhart ◽

T Efferth

Keyword(s):

Squamous Cell Carcinoma ◽

Targeted Therapy ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Natural Product ◽

Molecular Diagnostics ◽

Small Molecule ◽

Squamous Cell ◽

Molecular Targeted Therapy ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1004750.54854 ◽

2002 ◽

Author(s):

Carol Otey

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of Identification of small molecule inhibitors of anthrax lethal factor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016978.201559 ◽

2004 ◽

Author(s):

Kristina Downing

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Lethal Factor ◽

Anthrax Lethal Factor

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Faculty Opinions recommendation of Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1017973.285766 ◽

2005 ◽

Author(s):

George Perry

Keyword(s):

Small Molecule ◽

Amyloid Beta ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023153.264839 ◽

2005 ◽

Author(s):

Robert Kelley

Keyword(s):

T Cell ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

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Faculty Opinions recommendation of Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1024840.292879 ◽

2005 ◽

Author(s):

Chandra Kumar

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Phosphoinositide Dependent Kinase

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