scholarly journals Prognostic value of lymph node evaluation in small bowel adenocarcinoma

Cancer ◽  
2010 ◽  
Vol 116 (23) ◽  
pp. 5374-5382 ◽  
Author(s):  
Michael J. Overman ◽  
Chung-Yuan Hu ◽  
Robert A. Wolff ◽  
George J. Chang
Keyword(s):  
Lymph Node ◽  
Small Bowel ◽  
Prognostic Value ◽  
Small Bowel Adenocarcinoma ◽  
Lymph Node Evaluation

Implications of Lymph Node Evaluation in Crohn’s Patients with Small-Bowel Adenocarcinoma

2021 ◽  
Author(s):  
Richard J. Straker ◽  
Adrienne B. Shannon ◽  
Robert R. Roses ◽  
Douglas L. Fraker ◽  
Najjia N. Mahmoud ◽  
...  
Keyword(s):  
Lymph Node ◽  
Small Bowel ◽  
Small Bowel Adenocarcinoma ◽  
Lymph Node Evaluation

Small Intestine: Adenocarcinoma

2017 ◽  
Author(s):  
Joel M Baumgartner ◽  
Sudeep Banerjee ◽  
Jason K Sicklick
Keyword(s):  
Lymph Node ◽  
Small Bowel ◽  
Systemic Chemotherapy ◽  
Imaging Techniques ◽  
Distant Metastases ◽  
Lymph Node Involvement ◽  
Small Bowel Adenocarcinoma ◽  
Stage Disease ◽  
Node Involvement ◽  
Inflammatory Bowel

Adenocarcinoma is the second most common nonduodenal small bowel tumor. Small bowel adenocarcinoma has risk factors similar to those of colorectal adenocarcinoma but is rarer and less well understood. Diagnosis relies on advanced imaging techniques as well as endoscopy or enteroscopy for tissue diagnosis. Aggressive biology and vague symptoms in early disease cause a majority of patients to present with late-stage disease. Adenocarcinomas with lymph node involvement should be treated with resection and systemic chemotherapy. In contrast, systemic chemotherapy alone should be employed in cases with distant metastases unless the primary tumor is bleeding, perforated, or causing a bowel obstruction.   This review contains 4 figures, 5 tables and 17 references Key words: adenocarcinoma, chemotherapy, enteroscopy, hereditary syndrome, inflammatory bowel disease, lymph node, mesentery, small bowel  

Small Intestine: Adenocarcinoma

2017 ◽  
Author(s):  
Joel M Baumgartner ◽  
Sudeep Banerjee ◽  
Jason K Sicklick
Keyword(s):  
Lymph Node ◽  
Small Bowel ◽  
Systemic Chemotherapy ◽  
Imaging Techniques ◽  
Distant Metastases ◽  
Lymph Node Involvement ◽  
Small Bowel Adenocarcinoma ◽  
Stage Disease ◽  
Node Involvement ◽  
Inflammatory Bowel

Adenocarcinoma is the second most common nonduodenal small bowel tumor. Small bowel adenocarcinoma has risk factors similar to those of colorectal adenocarcinoma but is rarer and less well understood. Diagnosis relies on advanced imaging techniques as well as endoscopy or enteroscopy for tissue diagnosis. Aggressive biology and vague symptoms in early disease cause a majority of patients to present with late-stage disease. Adenocarcinomas with lymph node involvement should be treated with resection and systemic chemotherapy. In contrast, systemic chemotherapy alone should be employed in cases with distant metastases unless the primary tumor is bleeding, perforated, or causing a bowel obstruction.   This review contains 4 figures, 5 tables and 17 references Key words: adenocarcinoma, chemotherapy, enteroscopy, hereditary syndrome, inflammatory bowel disease, lymph node, mesentery, small bowel  

scholarly journals Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2018
Author(s):  
Erkki-Ville Wirta ◽  
Säde Szeto ◽  
Ulrika Hänninen ◽  
Maarit Ahtiainen ◽  
Jan Böhm ◽  
...  
Keyword(s):  
Small Bowel ◽  
Prognostic Value ◽  
Immune Cell ◽  
Small Bowel Adenocarcinoma ◽  
Prognostic Information ◽  
Environment Analysis ◽  
Characterization Methods ◽  
Programmed Death ◽  
Formalin Fixed Paraffin Embedded ◽  
Predisposing Conditions

Background: Small bowel adenocarcinoma (SBA) is a rare yet insidious cancer with poor survival. The abundance of tumour-infiltrating lymphocytes is associated with improved survival, but the role of the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway in tumour escape is controversial. We evaluated immune cell infiltration, PD1/PD-L1 expression and their prognostic value in a series of SBAs with previously verified predisposing conditions and exome-wide somatic mutation characterization. Methods: Formalin-fixed paraffin-embedded tissue sections stained for CD3, CD8, PD-L1 and PD-1 were analysed from 94 SBAs. An immune cell score (ICS) was formed from the amount of the CD3 and CD8 positive lymphocytes from the tumour centre and invasive margin. The PD-L1 and PD-1 positive immune cells (ICs) and ICS were combined into a variable called Immunoprofile. Results: High ICS, PD-L1IC and PD-1, individually and combined as Immunoprofile, were prognostic for better patient outcome. Sixty-five (69%) SBAs expressed ≥1% positive PD-L1IC. A high tumour mutation burden was common (19%) and associated with immune markers. Immunoprofile, adjusted for TNM stage, mismatch repair status, tumour location, sex and age were independent prognostic markers for disease-specific and overall survival. Conclusions: Analysing tumoral immune contexture provides prognostic information in SBA. Combining ICS, PD-1 and PD-L1IC as Immunoprofile enhanced the prognostic performance.

Prognostic relevance of lymph node ratio and total lymph node count for small bowel adenocarcinoma

Surgery ◽  
2015 ◽  
Vol 158 (2) ◽  
pp. 486-493 ◽  
Author(s):  
Thuy B. Tran ◽  
Motaz Qadan ◽  
Monica M. Dua ◽  
Jeffrey A. Norton ◽  
George A. Poultsides ◽  
...  
Keyword(s):  
Lymph Node ◽  
Small Bowel ◽  
Lymph Node Ratio ◽  
Small Bowel Adenocarcinoma ◽  
Lymph Node Count ◽  
Prognostic Relevance ◽  
Node Ratio ◽  
Node Count ◽  
Total Lymph Node

scholarly journals A rare case of jejunal adenocarcinoma with brain metastasis

2021 ◽  
Author(s):  
M. Harish ◽  
N. Hariprasad ◽  
R. Kannan
Keyword(s):  
Lymph Node ◽  
Small Bowel ◽  
Brain Metastasis ◽  
Delayed Diagnosis ◽  
Late Presentation ◽  
Lower Limbs ◽  
Jejunal Loop ◽  
Wall Thickening ◽  
Small Bowel Adenocarcinoma ◽  
Regional Lymphadenectomy

Small bowel malignancies are rare entity, with adenocarcinoma being one of common type along with neuroendocrine tumours. Associated with Crohns, celiac disease, FAP and HNPCC. Jejunal adenocarcinoma produce vague symptoms, accounting for late presentation leading to difficult and delayed diagnosis in favour of poor prognosis. Diagnosis is established by CECT abdomen and CEA levels. Ro resection with regional lymphadenectomy and jejunojejunal anastomosis is preferred followed by adjuvant FOLFOX chemotherapy. Here we presenting a 68 years old male, anaemic with vague abdominal pain for 3 months, CECT showed malignant wall thickening involving 10 cm of proximal jejunal loop with no enlarged lymph nodes and CEA was elevated. Proceeded with laparotomy, an irregular hard mass of 10×10 cm involving 20 cm of jejunum with transverse colon infiltration with multiple mesenteric nodes found, composite resection with jejunojejunostomy and colocolic anastomosis done. Histopathology showed poorly differentiated jejunal adenocarcinoma with colonic infiltration with reactive nodes and post operatively on day 7, patient developed seizures and weakness of left upper and lower limbs, MRI brain showed solitary metastasis 2×2 cm in right frontal region and PET CT showed brain metastasis and multiple intraabdominal lymph node, lung and prostate metastasis, planned SBRT for brain metastasis and palliative chemotherapy. Lymph node, liver and peritoneum are common site of metastasis for small bowel adenocarcinoma, very rarely brain metastasis can occur in short time and to be considered if neurological symptoms occur pre and postoperatively.

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