scholarly journals Single-Dose Bioequivalence of Two Mini Nicotine Lozenge Formulations

2017 ◽  
Vol 7 (5) ◽  
pp. 498-505 ◽  
Author(s):  
Scott C. Rasmussen ◽  
William D. Becker ◽  
Gilbert M. Shanga
Keyword(s):  
Single Dose ◽  
Nicotine Lozenge

Comparison of nicotine oral soluble film and nicotine lozenge on efficacy in relief of smoking cue-provoked acute craving after a single dose of treatment in low dependence smokers

2014 ◽  
Vol 231 (22) ◽  
pp. 4383-4391 ◽  
Author(s):  
Daniel Du ◽  
Mitchell Nides ◽  
James Borders ◽  
Alex Selmani ◽  
William Waverczak
Keyword(s):  
Single Dose ◽  
Nicotine Lozenge

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

Gastric Ulcers Produced by Cisplatin

1981 ◽  
Vol 39 ◽  
pp. 582-583
Author(s):  
S.K. Aggarwal ◽  
J. San Antonio
Keyword(s):  
Electron Microscopy ◽  
Single Dose ◽  
Side Effects ◽  
Antitumor Agent ◽  
Gastric Ulcers ◽  
Enzyme Cytochemistry ◽  
Intestinal Toxicity ◽  
Ovarian Cancers ◽  
Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: A randomized, double-blind single-dose study

1999 ◽  
Vol 66 (6) ◽  
pp. 625-635
Author(s):  
E BREIVIK ◽  
P BARKVOLL ◽  
E SKOVLUND
Keyword(s):  
Single Dose ◽  
Oral Surgery ◽  
Double Blind ◽  
Single Dose Study ◽  
Dose Study

A Single Dose of Adjuvant H1N1 Vaccine May Be OK

2010 ◽  
Vol 44 (2) ◽  
pp. 16
Author(s):  
HEIDI SPLETE
Keyword(s):  
Single Dose ◽  
H1n1 Vaccine

The Toxicity Profile of a Single Dose of Paroxetine: An Alternative Approach to Acute Toxicity Testing in the Rat

2001 ◽  
Vol 88 (2) ◽  
pp. 59-66 ◽  
Author(s):  
Pauline M. Ryan ◽  
John P. Kelly1Note ◽  
Philip L. Chambers ◽  
Brian E. Leonard
Keyword(s):  
Single Dose ◽  
Acute Toxicity ◽  
Toxicity Testing ◽  
Toxicity Profile ◽  
Alternative Approach ◽  
Acute Toxicity Testing

New single-dose drug shortens flu symptoms

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2018 ◽  
Keyword(s):  
Single Dose
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