Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells

2016 ◽  
pp. 1G.6.1-1G.6.18 ◽  
Author(s):  
Santosh Mathapati ◽  
Richard Siller ◽  
Agata A.R. Impellizzeri ◽  
Max Lycke ◽  
Karianne Vegheim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells

scholarly journals Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells

Blood ◽  
2017 ◽  
Vol 129 (26) ◽  
pp. 3428-3439 ◽  
Author(s):  
Mathew G. Angelos ◽  
Paige N. Ruh ◽  
Beau R. Webber ◽  
Robert H. Blum ◽  
Caitlin D. Ryan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Aryl Hydrocarbon Receptor ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Aryl Hydrocarbon ◽  
Small Molecule Inhibition ◽  
Receptor Inhibition ◽  
Key Points

Key Points Small-molecule inhibition and CRISPR/Cas9 deletion of AHR promote early hematoendothelial cell differentiation from hESCs. AHR inhibition enhances the differentiation of cNK cells from hESCs whereas AHR hyperactivation supports development of ILC3s.

scholarly journals Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

2015 ◽  
Vol 4 (5) ◽  
pp. 939-952 ◽  
Author(s):  
Richard Siller ◽  
Sebastian Greenhough ◽  
Elena Naumovska ◽  
Gareth J. Sullivan
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Hepatocyte Differentiation

scholarly journals Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells

2017 ◽  
Vol 24 ◽  
pp. 61-68 ◽  
Author(s):  
Azuma Kimura ◽  
Taro Toyoda ◽  
Yohei Nishi ◽  
Makoto Nasu ◽  
Akira Ohta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Progenitor Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells

scholarly journals Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

2012 ◽  
Vol 30 (7) ◽  
pp. 715-720 ◽  
Author(s):  
Stuart M Chambers ◽  
Yuchen Qi ◽  
Yvonne Mica ◽  
Gabsang Lee ◽  
Xin-Jun Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Developmental Timing ◽  
Small Molecule Inhibition

scholarly journals Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41958 ◽  
Author(s):  
Stefan Frank ◽  
Miao Zhang ◽  
Hans R. Schöler ◽  
Boris Greber
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells

scholarly journals A Small Molecule Inhibitor of Src Family Kinases Promotes Simple Epithelial Differentiation of Human Pluripotent Stem Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e60016 ◽  
Author(s):  
Xiaojun Lian ◽  
Joshua Selekman ◽  
Xiaoping Bao ◽  
Cheston Hsiao ◽  
Kexian Zhu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Small Molecule ◽  
Pluripotent Stem Cells ◽  
Small Molecule Inhibitor ◽  
Epithelial Differentiation ◽  
Human Pluripotent Stem Cells ◽  
Src Family Kinases ◽  
Molecule Inhibitor
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