Active matrix metalloproteinase‐8: A potential biomarker of oral systemic link

Background: Acute coronary syndrome (ACS) is the leading cause for morbidity and mortality in developed countries. Numerous groups have explored single and multiple biomarker strategies to identify diagnostic prognosticators of ACS which will improve our ability to identify high-risk individuals. Matrix metalloproteinase (MMP-9) is one potential biomarker which has been widely studied in ACS. Recent reports have showed the prognostic utility of MMP-9, but due to inconsistent results, it has not been possible to draw firm conclusions. Objective: This review aims to explore the ability of MMP-9 to predict long-term prognosis of ACS. To clarify this issue, we conducted a literature review to provide a comprehensive assessment of MMP-9 levels in ACS patients. Method: We retrieved a total of 1501 articles from PubMed and Google Scholar. After thorough scrutiny, 12 original research articles were found fulfilling the inclusion exclusion criteria. MMP-9’s ability as a biomarker of prognostication post ACS was reviewed. PRISMA guidelines were used for reporting. Result: The results revealed that MMP-9, apart from being an efficient diagnostic biomarker for ACS, helps in predicting the future risk of ACS with disease outcome. Positive correlation was found between plasma MMP-9 and left ventricular remodeling. A positive association was also found between cardiovascular death and higher MMP-9 levels. Conclusion: MMP-9 can be a potential prognostic marker for ACS and aid in identifying high risk patients for intensive management during follow -up.

Download Full-text

Origin of MMP-8 and Lactoferrin levels from gingival crevicular fluid, salivary glands and whole saliva

BMC Oral Health ◽

10.1186/s12903-021-01743-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Liza L. Ramenzoni ◽

Deborah Hofer ◽

Alex Solderer ◽

Daniel Wiedemeier ◽

Thomas Attin ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Salivary Glands ◽

Gingival Crevicular Fluid ◽

Clinical Parameters ◽

Pocket Depth ◽

Active Matrix ◽

Probing Pocket Depth ◽

Whole Saliva ◽

Biomarker Testing ◽

Crevicular Fluid

Abstract Background Pathologically elevated levels of matrix metalloproteinase-8 (MMP-8) and Lactoferrin in oral fluids have been associated with the presence of gingivitis/periodontitis. This study aimed to assess the origin of MMP-8 and Lactoferrin in periodontitis patients and to identify the degree to which conventional clinical parameters correlate with their presence. Methods A total of ten periodontitis and ten healthy patients were included in this study. Whole saliva (stimulated and unstimulated), parotid/sublingual glandular fluid and gingival crevicular fluid from pockets and sulci were tested for MMP-8 and Lactoferrin and protein concentrations were quantified using an ELISA assay. Clinical parameters were checked for potential associations with MMP-8 and Lactoferrin levels. Results Periodontal patients presented higher concentrations of MMP-8 and Lactoferrin in pockets than other sources (P = 0.03). Lactoferrin measurement was higher in the parotid compared to sublingual glandular fluid in periodontitis patients (P = 0.03). Increased probing pocket depth was positively correlated with high MMP-8 and Lactoferrin levels. Conclusions Periodontal pockets appear to be the major source of active matrix metalloproteinase and Lactoferrin, which also may also enter the oral cavity through the salivary glands. Since clinically healthy sites in periodontitis patients also had elevated biomarker levels, gingival crevicular fluid biomarker testing may be more predictive of future tissue breakdown than conventional clinical parameters.

Download Full-text

Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study

Expert Review of Proteomics ◽

10.1080/14789450.2020.1858056 ◽

2021 ◽

pp. 1-8

Author(s):

Mutlu Keskin ◽

Hanna Lähteenmäki ◽

Nilminie Rathnayake ◽

Ismo T. Räisänen ◽

Taina Tervahartiala ◽

...

Keyword(s):

Head And Neck Cancer ◽

Pilot Study ◽

Matrix Metalloproteinase ◽

Head And Neck ◽

Neck Cancer ◽

Interleukin 6 ◽

Active Matrix

Download Full-text

Characterization of the Monomeric and Dimeric Forms of Latent and Active Matrix Metalloproteinase-9

Journal of Biological Chemistry ◽

10.1074/jbc.275.4.2661 ◽

2000 ◽

Vol 275 (4) ◽

pp. 2661-2668 ◽

Cited By ~ 112

Author(s):

Matthew W. Olson ◽

M. Margarida Bernardo ◽

Martin Pietila ◽

David C. Gervasi ◽

Marta Toth ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Matrix Metalloproteinase 9 ◽

Active Matrix ◽

Metalloproteinase 9

Download Full-text

Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin

Liver International ◽

10.1111/j.1478-3231.2009.02070.x ◽

2009 ◽

Vol 29 (7) ◽

pp. 966-978 ◽

Cited By ~ 35

Author(s):

Stephen N. Hartland ◽

Frank Murphy ◽

Rebecca L. Aucott ◽

Armand Abergel ◽

Xiaoying Zhou ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Hepatic Stellate Cells ◽

Stellate Cells ◽

Matrix Metalloproteinase 2 ◽

Active Matrix

Download Full-text

Serum matrix metalloproteinase-2: A potential biomarker for diagnosis of epilepsy

Epilepsy Research ◽

10.1016/j.eplepsyres.2016.02.009 ◽

2016 ◽

Vol 122 ◽

pp. 114-119 ◽

Cited By ~ 4

Author(s):

Rui Wang ◽

Guang Qun Zeng ◽

Rui Zhan Tong ◽

Dong Zhou ◽

Zhen Hong

Keyword(s):

Matrix Metalloproteinase ◽

Matrix Metalloproteinase 2 ◽

Potential Biomarker

Download Full-text

Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

Journal of the American Heart Association ◽

10.1161/jaha.120.019372 ◽

2021 ◽

Vol 10 (5) ◽

Author(s):

Corey S. Moran ◽

Erik Biros ◽

Smriti M. Krishna ◽

Susan K. Morton ◽

Daniel J. Sexton ◽

...

Keyword(s):

Aortic Aneurysm ◽

Mouse Model ◽

Matrix Metalloproteinase ◽

Cyclooxygenase 2 ◽

Matrix Metalloproteinase 2 ◽

Prostaglandin E ◽

Blocking Antibody ◽

Active Matrix ◽

Suprarenal Aorta ◽

Metalloproteinase 9

Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation. Bradykinin is generated from high‐ and low‐molecular‐weight kininogen by the serine protease kallikrein‐1. The aims of this study were first to examine the effect of neutralizing kallikrein‐1 on AAA development in a mouse model and second to test how blocking kallikrein‐1 affected cyclooxygenase‐2 and prostaglandin E 2 in human AAA explants. Methods and Results Neutralization of kallikrein‐1 in apolipoprotein E‐deficient ( ApoE −/− ) mice via administration of a blocking antibody inhibited suprarenal aorta expansion in response to angiotensin (Ang) II infusion. Kallikrein‐1 neutralization decreased suprarenal aorta concentrations of bradykinin and prostaglandin E 2 and reduced cyclooxygenase‐2 activity. Kallikrein‐1 neutralization also decreased protein kinase B and extracellular signal‐regulated kinase 1/2 phosphorylation and reduced levels of active matrix metalloproteinase 2 and matrix metalloproteinase 9. Kallikrein‐1 blocking antibody reduced levels of cyclooxygenase‐2 and secretion of prostaglandin E 2 and active matrix metalloproteinase 2 and matrix metalloproteinase 9 from human AAA explants and vascular smooth muscle cells exposed to activated neutrophils. Conclusions These findings suggest that kallikrein‐1 neutralization could be a treatment target for AAA.

Download Full-text