Cytomorphology of Gastric-Type Cervical Adenocarcinoma on a ThinPrep Pap Test: Report of a p16-Positive Tumor Case

2016 ◽  
Vol 44 (8) ◽  
pp. 710-713 ◽  
Author(s):  
Clifton G. Fulmer ◽  
Rana S. Hoda ◽  
Edyta C. Pirog ◽  
Kay J. Park ◽  
Kevin Holcomb
Keyword(s):  
Pap Test ◽  
Cervical Adenocarcinoma ◽  
Test Report ◽  
Gastric Type

Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?

2021 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Tomoaki Naka ◽  
Mayumi Kobayashi-Kato ◽  
Nao Kikkawa ◽  
Yasuhito Tanase ◽  
...  
Keyword(s):  
Cervical Adenocarcinoma ◽  
Squamous Differentiation ◽  
Gastric Type

scholarly journals Comparison among the efficacy of interventions for the return rate to receive the pap test report: randomized controlled clinical trial

2017 ◽  
Vol 25 (0) ◽  
Author(s):  
Camila Teixeira Moreira Vasconcelos ◽  
Ana Karina Bezerra Pinheiro ◽  
Ana Izabel Oliveira Nicolau ◽  
Thaís Marques Lima ◽  
Denise de Fátima Fernandes Barbosa
Keyword(s):  
Clinical Trial ◽  
Pap Smear ◽  
Pap Test ◽  
Return Rate ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Test Report ◽  
Randomized Controlled ◽  
To Receive ◽  
Test Result

ABSTRACT Objective: to test the effects of a behavioral, an educative and a comparative intervention on women's adherence to the return appointment to receive the pap test report. Methods: randomized controlled clinical trial at a Primary Health Care Service, involving three groups: EG (educative session and test demonstration), BG (recall ribbon) and standard intervention (card containing the return appointment - graphical reminder), called comparative group here (CG). To select the sample, the following was established: having started sexual activity and undergoing the pap smear during the study, resulting in 775 women. Results: among the 775 women, 585 (75.5%) returned to receive the test result within 65 days. The educative group presented the highest return rate (EG=82%/CG=77%/BG=66%), statistically significant only when compared to the behavioral group (p=0.000). The educative group obtained the smallest interval (p<0.05) concerning the mean number of days of return to receive the test result (EG:M=43days/BG:M=47.5days/CG:M=44.8 days). Conclusion: the educative group reached higher return rates and the women returned earlier, but the behavioral intervention showed to be the least effective. Brazilian Clinical Trial Register: RBR-93ykhs.

scholarly journals A Retrospective Study on Incidence, Diagnosis, and Clinical Outcome of Gastric-type Endocervical Adenocarcinoma in a Single Institution

2021 ◽  
Author(s):  
Anna Radomska ◽  
Daniel Lee ◽  
Heather Neufeld ◽  
Nancy Korte ◽  
Emina Torlakovic ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Kinase Inhibitor ◽  
P53 Protein ◽  
Progesterone Receptors ◽  
Cervical Adenocarcinoma ◽  
Single Institution ◽  
Mutant Type ◽  
Usual Type ◽  
Endocervical Adenocarcinoma ◽  
Gastric Type

Abstract Background: Gastric-type endocervical adenocarcinoma is rare but the most common subtype of cervical adenocarcinoma not associated with human papillomavirus. It is more aggressive with a shorter five-year survival rate compared to human papillomavirus-associated usual type endocervical adenocarcinoma. The objectives of our study were to determine the incidence and clinical-pathological characteristics of Gastric-type endocervical adenocarcinoma in a single institution. Methods: Twenty four cases of invasive cervical adenocarcinoma were identified between January 2000 and December 2015, from the Saskatoon Health Region pathology database using International Endocervical Adenocarcinoma Criteria and Classification to retrospectively classify endocervical adenocarcinoma. Immunohistochemistry was performed with antibodies for Gastric mucin-6 (MUC-6), p16INK4a, cyclin-dependent kinase inhibitor 2A (p16), p53 protein (p53), estrogen and progesterone receptors. Clinical and pathological data was retrieved from pathology reports and charts. Statistical analysis was performed using Mann-Whitney U test and Chi-Square test.Results: Using the International Endocervical Adenocarcinoma Criteria and Classification criteria, 19 cases (79.2%) were classified as human papillomavirus-associated usual type endocervical adenocarcinoma, and five cases (20.8%) as Gastric-type endocervical adenocarcinoma. In our study 40% of Gastric-type endocervical adenocarcinoma cases presented at stage III compared to none of the usual type endocervical carcinoma cases. All the Gastric-type endocervical adenocarcinoma cases were positive for MUC-6, and negative for p16. 60% Gastric-type endocervical adenocarcinoma cases demonstrated mutant type p53 staining. In contrast, 84.2% of human papillomavirus-associated usual type endocervical adenocarcinoma cases showed block like nuclear and cytoplasmic positivity with p16 antibodies. The Gastric-type endocervical adenocarcinoma group had significantly shorter median survival time than human papillomavirus-associated usual type endocervical adenocarcinoma group, Gastric-type endocervical adenocarcinoma is 22 months compared to human papillomavirus-associated usual type endocervical adenocarcinoma at 118 months (p = 0.043). Conclusions: In this study, Gastric-type endocervical adenocarcinoma accounted for 20.8% of all cervical adenocarcinoma with higher stage at presentation and shorter overall survival. Histomorphology and immunohistochemistry for MUC-6 and p16 could differentiate between Gastric-type endocervical adenocarcinoma and human papillomavirus-associated usual type endocervical adenocarcinoma.

scholarly journals Abstract 2930: Characterization based on therapeutic target biomarkers of patients-driven xenografts model of gastric-type cervical adenocarcinoma

2021 ◽  
Author(s):  
Yuki Kojima ◽  
Hiroshi Yoshida ◽  
Toshihiro Okuya ◽  
Hitomi S. Okuma ◽  
Tadaaki Nishikawa ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Cervical Adenocarcinoma ◽  
Gastric Type

Cytomegalovirus inclusions on a cervical pap test: Report of a well-known organism at an uncommon site

2007 ◽  
Vol 35 (9) ◽  
pp. 618-620 ◽  
Author(s):  
Girish Venkataraman ◽  
George Kouria ◽  
Swati Mehrotra ◽  
Christine N. Booth ◽  
Rasheed Hammadeh ◽  
...  
Keyword(s):  
Pap Test ◽  
Test Report

scholarly journals A Tumor of Composite Cervical Adenocarcinoma with MUCIN Gene Mutation：A Case Report

2021 ◽  
Author(s):  
Meijun Guo ◽  
Guoping Li ◽  
Xiuxiu Jiang ◽  
Shiming Lv
Keyword(s):  
Cervical Cancer ◽  
Gene Mutations ◽  
Gene Sequencing ◽  
Enrichment Analysis ◽  
Cervical Adenocarcinoma ◽  
Cervical Lesions ◽  
Transitional Area ◽  
Mucin Gene ◽  
Gastric Type ◽  
Minimal Deviation

Abstract Background:There are reports about the coexistence of two kinds of tumors in the same patient,which is believed that this phenomenon is caused by the dedifferentiation between the two tumors.In this paper, we report an human papillomavirus (HPV) negative cervical adenocarcinoma in a patient composed of two adenocarcinoma components,which is first reported.Histologically, both minimal deviation adenocarcinoma (MDA) and poorly differentiated gastric type adenocarcinoma (GTA) components, as well as their transitional area, were observed.Methods:This case of cervical cancer was screened by gene sequencing. For detection of specific somatic mutations in MDA and GTA, we filtered out mutations in malignant cervical cancer blood sample and 7 common cervical carcinoma. Then the genes were screened and identified based on the enrichment analysis of GO and KEGG and related literature reports. Results:We found 13 specific somatic gene mutations in total. Among these genes, only Mucin gene was transformed from gene level to protein level, and was positive in both MDA and GTA components of the patient by immunohistochemistry.Both components had genes mutation of MUC4 and MUC17,the component in MDA had gene mutation of MUC3A,and we found that MUC3A and MUC17 were on the same chromosome. Moreover,MUC3A and MUC4 genes were found to be fused in FusionGDB database. Conclusion:According to the reports of MUC3A,MUC4 and MUC17 genes mutation in cervical adenocarcinoma and gene fusions in tumorigenesis, we speculate that the occurrence of the transformation of pathological type from MDA to GTA in this case of cervical cancer is related to the mechanism of MUC3A and MUC4 gene fusion.We would advice, for HPV negative or atypical cervical lesions, immunohistochemistry of MUCIN genes staining and gene sequencing should be considered, which may find unusual cancer types and change the prognosis of patients.

scholarly journals Morphologic Features of Gastric-type Cervical Adenocarcinoma in Small Surgical and Cytology Specimens

2019 ◽  
Vol 38 (3) ◽  
pp. 263-275 ◽  
Author(s):  
Gulisa Turashvili ◽  
Elizabeth G. Morency ◽  
Mihaela Kracun ◽  
Deborah F. DeLair ◽  
Sarah Chiang ◽  
...  
Keyword(s):  
Cervical Adenocarcinoma ◽  
Gastric Type
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