Создание равномерных покрытий импульсным лазерным осаждением

The present paper deals with the selection of laser beam processing parameters that guarantee the formation of thin coatings with even thickness by means of the laser beam deposition. Laser deposition was carried out in the atmosphere of Ar and Si and SiC samples were used as a source for the deposited material. Preliminary experiments show that there is a direct dependency between the brightness of the image of the deposited layer (at uniform illumination conditions) and its thickness. Therefore, it was possible to determine the thickness of the deposited layer for various processing parameters and to calculate the laws of motion of the work piece that guarantee the deposition of the layer with a minimal deviation of thickness from the required value. Calculated parameters were successfully used for the deposition of coatings on a substrate of a relatively large area.

Effective dielectric properties of Cement/Ba0.06(Na0.5Bi0.5)0.94TiO3 composites: A comparative approach

Lead-free ceramic powder of a morphotropic phase boundary composition Ba0.06(Na0.5Bi0.5)0.94TiO3 (BNBT) was prepared from a solid-state synthesis route. The cement-ceramic (1−ϕ)cement/ϕBNBT; 0 ≤ ϕ 1.0 composites were fabricated. The filler concentration-dependent values of the bulk density and real part of complex permittivity showed an increasing trend of variation while the apparent porosity and imaginary part of complex permittivity followed a decreasing trend. In order to test the acceptability of dielectric mixture equations of the inclusion material in the mixture, five such equations have been chosen. The Bruggeman, and Rother-Lichtenecker equations showed their coherence with minimal deviation from the experimental results of the real part of complex permittivity for the entire measurement range of volume fractions. Also, a first-order exponential growth/decay type of mathematical model was suggested which could fit the experimental data excellently well (r2 > 0.97).

A RARE CASE OF MINIMAL DEVIATION ADENOCARCINOMA OF CERVIX – A CASE REPORT

Minimal deviation adenocarcinoma is a subtype of cervical adenocarcinoma and accounts for 1-3% of cervical adenocarcinoma . It is also known as adenoma malignum. We report a case of 55 year old postmenopausal women with complaints of low back pain, on examination cervix was replaced by indurated growth and was diagnosed as minimal deviation adenocarcinoma of cervix by biopsy

Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas

Background We aimed to analyze the clinicopathological features and outcomes of patients with gastric-type of HPV-independent endocervical adenocarcinoma (GAS HPVI ECA), and compare them with non-GAS HPVI ECA cases. Methods Thirty-eight GASs [including 17 minimal deviation adenocarcinoma (MDA), 21 non-MDA GAS] and 17 non-GAS HPVI ECAs were studied. Data of clinical features, pathological characteristics, treatment, and outcomes were evaluated. Results The median age of patients with GAS and non-GAS HPVI ECA was 46 and 48 years, respectively (p = 0.93). Compared with non-GAS HPVI ECAs, GAS had more common complains of vaginal watery discharge (p = 0.04). GAS cases were also associated with higher clinical stage (p = 0.036), more common in deeper cervical stromal invasion (p = 0.002) and lymphoavascular invasion (p = 0.044). GAS was associated with worse median progression-free survival (PFS) (p = 0.02) and median overall survival (OS) (p = 0.03) over patients with non-GAS HPVI ECAs. MDA had similar clinical and pathological features and prognosis compared with non-MDA GAS. Of note, serum CA19–9 levels were significantly higher in GAS than that in non-GAS HPVI ECA cases. Conclusions GAS cases were more likely to have high risk pathological factors and poorer PFS and OS compared with non-GAS HPVI ECAs. Serum CA19–9 may be helpful for diagnosis and screening in patients with GAS.

Difficult Diagnosis of Minimal-deviation Adenocarcinoma of the Uterine Cervix: a Case Report and Review of the Literature.

Background: Minimal-deviation adenocarcinoma (MDA) is a rare form of cervical adenocarcinoma. The clinical manifestations of MDA were not typical. Cervical cancer screening is not always effective at screening for MDA. Early clinical manifestations of MDA were lack of specificity and frequently regarded as cervicitis, the effect of treatment was usually poor. The cytological characteristics of MDA were similar to the normal cervical endometrial glands. It was difficult to distinguish between MDA and benign endometrial lesions. Therefore, early diagnosis difficulties often lead to delayed diagnosis.Case presentation: A rare case of MDA of the uterine cervix undergoing a hard process to make a confirmed diagnosis is reported. This case, with an initial complaint of cervical contact bleeding, pelvic pain, and vaginal itching, was negative for Thinprep cytologic test (TCT), the human papillomavirus (HPV) genotyping test by Hybrid Capture 2 (HC2), and cervical biopsies. Finally, the MDA was diagnosed with the assistance of the Bard-Magnum Biopsy Instrument under computed tomographic (CT) guidance and staged as an IIIB tumor according to the 2009 International Federation of Gynecology and Obstetrics (FIGO) staging system. The patient received concurrent chemoradiation as primary treatment and unfortunately died a few months later.Conclusion: Thus, MDA should be considered in the differential diagnosis of a cervical space-occupying lesion with negative HPV, cervical cytology, and biopsy. With the assistance of the Bard-Magnum Biopsy Instrument, CT-guided biopsy of deep cervical tissues could improve the early diagnosis rate of MDA, which was helpful for clinicians in early diagnosis.

A tumor of composite cervical adenocarcinoma with MUCIN gene mutation：a case report

Background : There are reports about the coexistence of two kinds of tumors in the same patient,which is believed that this phenomenon is caused by the dedifferentiation between the two tumors.In this paper, we report an human papillomavirus (HPV) negative cervical adenocarcinoma in a patient composed of two adenocarcinoma components,which is first reported.Histologically, both minimal deviation adenocarcinoma (MDA) and poorly differentiated gastric type adenocarcinoma (GTA) components, as well as their transitional area, were observed.Methods : This case of cervical cancer was screened by gene sequencing. For detection of specific somatic mutations in MDA and GTA, we filtered out mutations in malignant cervical cancer blood sample and 7 common cervical carcinoma. Then the genes were screened and identified based on the enrichment analysis of GO and KEGG and related literature reports. Results : We found 13 specific somatic gene mutations in total. Among these genes, only Mucin gene was transformed from gene level to protein level, and was positive in both MDA and GTA components of the patient by immunohistochemistry.Both components had genes mutation of MUC4 and MUC17,the component in MDA had gene mutation of MUC3A,and we found that MUC3A and MUC17 were on the same chromosome. Moreover,MUC3A and MUC4 genes were found to be fused in FusionGDB database. Conclusion : According to the reports of MUC3A,MUC4 and MUC17 genes mutation in cervical adenocarcinoma and gene fusions in tumorigenesis, we speculate that the occurrence of the transformation of pathological type from MDA to GTA in this case of cervical cancer is related to the mechanism of MUC3A and MUC4 gene fusion.We would advice, for HPV negative or atypical cervical lesions, immunohistochemistry of MUCIN genes staining and gene sequencing should be considered, which may find unusual cancer types and change the prognosis of patients.

The importance of correct radiological diagnosis in (adenoma malignum): a case report

ABSTRACT Minimal deviation adenocarcinoma (MDA) of the cervix otherwise known as adenoma malignum is a rare variation of cervical adenocarcinoma. Radiological evaluation plays a great role to ensure an early diagnosis. Here, we report a 48-year-old woman who was presented with a mucoid vaginal discharge 10 years after a supracervical hysterectomy. Despite normal biopsy and cytology, magnetic resonance imaging showed a large cervix and multiple cervical cysts that considered adenoma malignum as a differential diagnosis. She underwent surgery and the pathology confirmed the adenoma malignum. In conclusion, radiologists, as well as gynecologists, and also pathologists may consider MDA among the differential diagnosis in patients with a vaginal discharge and multicysts in the cervix even after hysterectomy despite normal cytology and biopsy.