scholarly journals Methotrexate‐associated proliferative disorder in the lower esophagus extending to the gastroesophageal junction: A case report

DEN Open ◽  
2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Yuki Hojo ◽  
Masafumi Takatsuna ◽  
Satoshi Ikarashi ◽  
Hiroteru Kamimura ◽  
Rika Kimura ◽  
...  
F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 490
Author(s):  
Yasmine Hussein Agha ◽  
Nathaniel A. Parker ◽  
Joel Alderson

Primary malignant melanoma represents the fifth most common cancer in the United States. It is subdivided into two forms: cutaneous (90%), visceral (8%, including ocular and mucosal) and of unknown primary (2%). The vast majority of gastrointestinal melanomas are secondary lesions until proven otherwise. Primary esophageal melanoma in particular is exceedingly rare, less than 200 cases have been documented in the literature to date. It is highly prevalent in Japan and occurs twice as much in men than women around the 6th decade of life. It has a predilection for the middle and lower esophagus, with only 6 cases occurring at the gastroesophageal junction worldwide. Its etiology and pathogenesis are poorly understood, and no curative treatment has been established given the paucity of cases. We present a case of primary melanoma of the gastroesophageal junction which represents the 2nd incident case in the united states and 7th worldwide.


2021 ◽  
Vol 81 ◽  
pp. 105786
Author(s):  
Dinesh Prasad Koirala ◽  
Bibek Man Shrestha ◽  
Ankush Kansal ◽  
Diptee Poudel ◽  
Subita Neupane ◽  
...  

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Sharhanin Bahrudin

Introduction: Esophageal cancer is the fifth most common cancer in Asia. Synchronous malignancies with an esophageal malignancies is not uncommon however synchronous esophageal malignancy and renal cell carcinoma is rare. Case Report: A 70 years old non smoker man with comorbid of hypertension and diabetes mellitus presented with multiple episode of hemoptysis and pleuritic chest pain within one day duration. He also complaint of worsening dysphagia to solid food for 1 month duration with constitutional symptoms. Otherwise he does not have any other symptoms. Clinically he was pale and cachexic, otherwise all systemic examination was unremarkable. His blood investigation reveal low hemoglobin level of 9.9g/L with normal coagulation and renal profile. He underwent Oesophagoduodenoscopy which showed a tumor narrowing the lumen of the lower esophagus. Biopsy of the tumor revealed esophageal adenocarcinoma. CT thorax, abdomen and pelvis showed smooth circumferential wall thickening of the distal part of the esophagus near the gastroesophageal junction. Incidentally, there were heterogenous enhancing lobulated mass seen at the lower pole of left kidney with no obstructive uropathy features. Otherwise, others solid organ were normal. A left renal mass biopsy performed revealed renal cell carcinoma. An oncologist opinion was gathered for initiation of palliative chemotherapy however he developed symptomatic malignant pleural effusion which need a drainage. HRCT Thorax revealed multiple bilateral intrapulmonary nodule. He also complaint of a new right upper eyelid mass that increasing in size with contact bleeding however does not affect his visual. An assessment from an ophthalmologist and CT orbital performed consistent with features of a metastasis. Conclusion: Synchronous malignancies with an esophageal malignancies is not uncommon. Most common site reported is head and neck followed by lung malignancies. However synchronous esophageal malignancies and renal cell carcinoma is rare. Esophageal malignancies often have distant metastasis to the liver, lung and bone however rare to the eyelid.


2020 ◽  
Vol 76 ◽  
pp. 11-13
Author(s):  
Adil Ayub ◽  
Buria Naeem ◽  
Mollie Ahn ◽  
Kanika Bowen-Jallow ◽  
Sifrance Tran

2008 ◽  
Vol 123 (4) ◽  
pp. 471-474
Author(s):  
S Al-Zahid ◽  
J Clarke ◽  
C Roberts

AbstractObjective:We report an extremely rare upper airway complication of oesophageal stent failure.Case report:A 58-year-old woman presented four months after having a covered (anti-reflux valve type) oesophageal stent placed for a benign oesophageal stricture. Abdominal radiography showed a broken fragment at the gastroesophageal junction and another fragment in the rectum. On presentation, the patient had pneumonia with sepsis which required intensive care management. After recovery, she developed sinus symptoms of facial pain, green nasal discharge and bilateral hearing loss. ENT review revealed bilateral otitis media with effusion. Flexible naso-endoscopy found a stent fragment lodged in the nasopharynx. The wire mesh fragment was removed under general anaesthetic and bilateral grommets inserted. The patient's symptoms resolved.Conclusions:To our knowledge, this is the first report in the world literature of a broken and migrated oesophageal stent presenting with chronic sinusitis and bilateral hearing loss. This case highlights the importance of examining the upper airways in such cases, and the need for further, long term studies of the complications of metallic, expandable stents.


Author(s):  
José Francisco Juanmartiñena ◽  
Ignacio Fernández-Urien ◽  
Alicia Córdoba ◽  
Coro Miranda Murua ◽  
Ana Borda

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