Layered Yttrium Hydroxide as a Host for Enhancing the UV‐Protective Capacity and Photostability of Benzophenone‐5

Background:Brucellosis is an infectious disease caused by Brucella bacteria that cause disease in animals and humans. Brucellosis is one of the most common zoonotic diseases transmitted from animals-to-human through direct contact with infected animals and also consumption of unpasteurized dairy products. Due to the wide incidence of brucellosis in Iran and economical costs in industrial animal husbandry, Vaccination is the best way to prevent this disease. All of the available commercial vaccines against brucellosis are derived from live attenuated strains of Brucella but because of the disadvantage of live attenuated vaccines, protective subunit vaccine against Brucella may be a good candidate for the production of new recombinant vaccines based on Brucella Outer Membrane Protein (OMP) antigens. In the present study, comprehensive bioinformatics analysis has been conducted on prediction software to predict T and B cell epitopes, the secondary and tertiary structures and antigenicity of Omp16 antigen and the validation of used software confirmed by experimental results.Conclusion:The final epitope prediction results have proposed that the three epitopes were predicted for the Omp16 protein with antigenicity ability. We hypothesized that these epitopes likely have the protective capacity to stimulate both the B-cell and T-cell mediated immune responses and so may be effective as an immunogenic candidate for the development of an epitope-based vaccine against brucellosis.

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Methodology for Increasing the Efficiency of Dynamic Process Calculations in Elastic Elements of Complex Engineering Constructions

Electronics ◽

10.3390/electronics10010040 ◽

2020 ◽

Vol 10 (1) ◽

pp. 40

Author(s):

Andriy Andrukhiv ◽

Maria Sokil ◽

Solomiia Fedushko ◽

Yuriy Syerov ◽

Yaryna Kalambet ◽

...

Keyword(s):

Dynamic Process ◽

Granular Media ◽

Homogeneous Medium ◽

Dynamic Processes ◽

Analytical Relationship ◽

Operational Parameters ◽

Protective Capacity ◽

Vibration Displacement ◽

Complex Engineering ◽

Elastic Elements

This study deals with a methodology for increasing the efficiency of dynamic process calculations in elastic elements of complex engineering constructions. We studied the complex dynamic processes in a simple engineering construction, a mechanical system of an elastic body–continuous flow of homogeneous medium. The developed methodology is based on the use of a priori information on some of the vibrations forms, the construction of a “simplified” mathematical model of system dynamics, and the obtaining of an analytical relationship that describe the overall range of factors on the elastic vibrations of system. The methodology is used for cases of complex vibrations of elastic bodies, and the obtained results can serve as a basis for choosing the main technological and operational parameters of elastic elements of mechanisms and machines that perform complex vibrations. The results obtained in this work are the basis for calculating the blast effect on the elements of protective structures in order to increase their protective capacity by improving the method of their attachment or by using additional reinforcement, buff load effects on the elements of drilling strings and dynamic processes that occur during surface strengthening by work hardening in order to avoid resonance phenomena, and technological processes of vibration displacement or vibration separation of granular media.

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