Cover Feature: Smartphone-based colorimetric chiral recognition of ibuprofen using aptamers-capped gold nanoparticles

Abstract Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer’s disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeutics. Here we design and prepare 3.3 nm L- and D-glutathione stabilized gold nanoparticles (denoted as L3.3 and D3.3, respectively). Both chiral nanoparticles are able to inhibit aggregation of Aβ42 and cross the blood-brain barrier (BBB) following intravenous administration without noticeable toxicity. D3.3 possesses a larger binding affinity to Aβ42 and higher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of Aβ42 fibrillation and better rescue of behavioral impairments in AD model mice. This conjugation of a small nanoparticle with chiral recognition moiety provides a potential therapeutic approach for AD.

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A universal strategy for visual chiral recognition of α-amino acids with l-tartaric acid-capped gold nanoparticles as colorimetric probes

The Analyst ◽

10.1039/c5an02434j ◽

2016 ◽

Vol 141 (4) ◽

pp. 1257-1265 ◽

Cited By ~ 29

Author(s):

Guoxin Song ◽

Fulin Zhou ◽

Chunli Xu ◽

Baoxin Li

Keyword(s):

Amino Acids ◽

Gold Nanoparticles ◽

Tartaric Acid ◽

Chiral Recognition ◽

Color Change ◽

Blue Color ◽

Left Handed

All of 19 right-handed α-amino acids can induce a red-to-blue color change of l-tartaric acid-capped AuNP solution, whereas all of the left-handed amino acids (except cysteine) cannot.

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Visual chiral recognition of D/L-leucine using cube-shaped gold nanoparticles as colorimetric probes

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2019.117263 ◽

2019 ◽

Vol 223 ◽

pp. 117263 ◽

Cited By ~ 8

Author(s):

Xiaojuan Zhou ◽

Chunli Xu ◽

Yan Jin ◽

Baoxin Li

Keyword(s):

Gold Nanoparticles ◽

Chiral Recognition

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Correction: A universal strategy for visual chiral recognition of α-amino acids with l-tartaric acid-capped gold nanoparticles as colorimetric probes

The Analyst ◽

10.1039/c7an90049j ◽

2017 ◽

Vol 142 (14) ◽

pp. 2678-2678

Author(s):

Guoxin Song ◽

Fulin Zhou ◽

Chunli Xu ◽

Baoxin Li

Keyword(s):

Amino Acids ◽

Gold Nanoparticles ◽

Tartaric Acid ◽

Chiral Recognition

Correction for ‘A universal strategy for visual chiral recognition of α-amino acids with l-tartaric acid-capped gold nanoparticles as colorimetric probes’ by Guoxin Song et al., Analyst, 2016, 141, 1257–1265.

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A biosensing interface based on Au@BSA nanocomposite for chiral recognition of propranolol

Analytical Methods ◽

10.1039/c6ay00272b ◽

2016 ◽

Vol 8 (17) ◽

pp. 3564-3569 ◽

Cited By ~ 10

Author(s):

Chunzhi Xuan ◽

Qiao Xia ◽

Juanjuan Xu ◽

Qinghong Wang ◽

Xia Lin ◽

...

Keyword(s):

Gold Nanoparticles ◽

Bovine Serum Albumin ◽

Serum Albumin ◽

Bovine Serum ◽

Chiral Recognition ◽

Electrochemical Sensing

The nanocomposite (Au@BSA) which was synthesized using gold nanoparticles (AuNPs) and bovine serum albumin (BSA) was used as an electrochemical sensing layer for chiral recognition of propranolol (PRO).

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Application of Chiral Ionic Liquid-Modified Gold Nanoparticles in the Chiral Recognition of Amino Acid Enantiomers

Applied Spectroscopy ◽

10.1177/0003702816645353 ◽

2016 ◽

Vol 70 (10) ◽

pp. 1649-1654 ◽

Cited By ~ 10

Author(s):

Lu Huang ◽

Yi-Ting Chen ◽

Yan-Xia Li ◽

Li-Shuang Yu

Keyword(s):

Gold Nanoparticles ◽

Amino Acid ◽

Chiral Recognition ◽

Visible Spectroscopy ◽

Recognition Mechanism ◽

Chiral Ionic Liquids ◽

Amino Acid Enantiomers ◽

Transmission Electron ◽

Chiral Ionic Liquid

Two chiral ionic liquids (ILs), namely 1-ethyl-3-methylimidazole l-tartrate (EMIML-Tar) and 1-ethyl-3-methylimidazole l-lactate (EMIML-Lac), were used to modify gold nanoparticles (AuNPs) for chiral recognition of amino acid enantiomers. Transmission electron microscopy, infrared spectroscopy, ultraviolet-visible spectroscopy, and capillary electrophoresis were used for the characterization of chiral IL-modified AuNPs. Meanwhile, the performance of l-tartaric acid and l-lactic acid as modifiers was investigated to make a comparison. The chiral recognition mechanism is further discussed.

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