Acute exposure of human lung cells to 1,3-butadiene diepoxide results in G1 and G2 cell cycle arrest

2005 ◽  
Vol 45 (4) ◽  
pp. 354-364 ◽  
Author(s):  
Michael Schmiederer ◽  
Eugene Knutson ◽  
Perpetua Muganda ◽  
Thomas Albrecht
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Lung ◽  
Acute Exposure ◽  
Lung Cells ◽  
Cycle Arrest ◽  
Human Lung Cells ◽  
G2 Cell Cycle Arrest

scholarly journals Overexpression of cyclin L2 induces apoptosis and cell-cycle arrest in human lung cancer cells

2007 ◽  
Vol 120 (10) ◽  
pp. 905-909 ◽  
Author(s):  
Hong-li LI ◽  
Tong-shan WANG ◽  
Xiao-yu LI ◽  
Nan LI ◽  
Ding-zhi HUANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Cycle Arrest ◽  
Human Lung Cancer Cells

scholarly journals Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells

2015 ◽  
Vol 48 (1) ◽  
pp. 67-77 ◽  
Author(s):  
P. Plaimee ◽  
N. Weerapreeyakul ◽  
S. Barusrux ◽  
N. P. Johns
Keyword(s):  
Cell Cycle ◽  
Lung Adenocarcinoma ◽  
Cell Cycle Arrest ◽  
Human Lung ◽  
Human Lung Adenocarcinoma ◽  
Cycle Arrest ◽  
Adenocarcinoma Cells ◽  
Human Lung Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
Induced Apoptosis

scholarly journals G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells

FEBS Letters ◽  
1999 ◽  
Vol 461 (3) ◽  
pp. 299-305 ◽  
Author(s):  
Wai Yi Siu ◽  
Cain H Yam ◽  
Randy Y.C Poon
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
G2 Cell Cycle Arrest

HIV-1 Vpr: G2 cell cycle arrest, macrophages and nuclear transport

1997 ◽  
pp. 21-27 ◽  
Author(s):  
Fabio Re ◽  
Jeremy Luban
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Nuclear Transport ◽  
Cycle Arrest ◽  
G2 Cell Cycle Arrest ◽  
Hiv 1

scholarly journals Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest

2017 ◽  
Vol 21 (1) ◽  
pp. 107-119.e6 ◽  
Author(s):  
Phong Dang Nguyen ◽  
David Baruch Gurevich ◽  
Carmen Sonntag ◽  
Lucy Hersey ◽  
Sara Alaei ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Cycle Arrest ◽  
Tissue Growth ◽  
Muscle Stem Cells ◽  
Cycle Arrest ◽  
G2 Cell Cycle Arrest

scholarly journals Leptospermum flavescens Constituent-LF1 Causes Cell Death through the Induction of Cell Cycle Arrest and Apoptosis in Human Lung Carcinoma Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135995 ◽  
Author(s):  
Suerialoasan Navanesan ◽  
Norhanom Abdul Wahab ◽  
Sugumaran Manickam ◽  
Kae Shin Sim
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Cell Cycle Arrest ◽  
Lung Carcinoma ◽  
Human Lung ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Cycle Arrest ◽  
Human Lung Carcinoma

scholarly journals Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest

2020 ◽  
Vol 527 (1) ◽  
pp. 257-263
Author(s):  
Kayoko Nagata ◽  
Keisuke Shindo ◽  
Yusuke Matsui ◽  
Kotaro Shirakawa ◽  
Akifumi Takaori-Kondo
Keyword(s):  
Cell Cycle ◽  
Protein Degradation ◽  
Cell Cycle Arrest ◽  
Critical Role ◽  
Cycle Arrest ◽  
Family Protein ◽  
G2 Cell Cycle Arrest ◽  
Hiv 1

Viriditoxin Induces G2/M Cell Cycle Arrest and Apoptosis in A549 Human Lung Cancer Cells

2015 ◽  
Vol 21 (4) ◽  
pp. 282 ◽  
Author(s):  
Ju Hee Park ◽  
Tae Hwan Noh ◽  
Haibo Wang ◽  
Nam Deuk Kim ◽  
Jee H. Jung
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
M Cell ◽  
Cycle Arrest ◽  
Human Lung Cancer Cells

scholarly journals Weighted Correlation Network Analysis Reveals CDK2 as a Regulator of a Ubiquitous Environmental Toxin-Induced Cell-Cycle Arrest

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 143
Author(s):  
Virginie Dubourg ◽  
Alexander Nolze ◽  
Michael Kopf ◽  
Michael Gekle ◽  
Gerald Schwerdt
Keyword(s):  
Cell Cycle ◽  
Network Analysis ◽  
Cell Cycle Arrest ◽  
Regulation Of Gene Expression ◽  
Correlation Network ◽  
Food Contaminants ◽  
Proximal Tubule Cells ◽  
Cycle Arrest ◽  
G2 Cell Cycle Arrest ◽  
Weighted Correlation

Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms. We applied a top-down approach to identify relevant toxicological mechanisms of OTA using RNA-sequencing followed by in-depth bioinformatics analysis and experimental validation. Differential expression analyses revealed that OTA led to the regulation of gene expression in kidney human cell lines, including for genes enriched in cell cycle-related pathways, and OTA-induced gap 1 and 2 (G1 and G2) cell-cycle arrests were observed. Weighted correlation network analysis highlighted cyclin dependent kinase 2 (CDK2) as a putative key regulator of this effect. CDK2 was downregulated by OTA exposure, and its overexpression partially blocked the OTA-induced G1 but not G2 cell-cycle arrest. We, therefore, propose CDK2 as one of the key regulators of the G1 cell-cycle arrest induced by low nanomolar concentrations of OTA.

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