scholarly journals Global gene expression response of a population exposed to benzene: A pilot study exploring the use of RNA-sequencing technology

2013 ◽  
Vol 54 (7) ◽  
pp. 566-573 ◽  
Author(s):  
Reuben Thomas ◽  
Cliona M. McHale ◽  
Qing Lan ◽  
Alan E. Hubbard ◽  
Luoping Zhang ◽  
...  



2018 ◽  
Vol 9 ◽  
Author(s):  
Diego Robledo ◽  
Alejandro P. Gutiérrez ◽  
Agustín Barría ◽  
José M. Yáñez ◽  
Ross D. Houston


2005 ◽  
Vol 115 (3) ◽  
pp. 221-237 ◽  
Author(s):  
T. Polen ◽  
M. Krämer ◽  
J. Bongaerts ◽  
M. Wubbolts ◽  
V.F. Wendisch


2005 ◽  
Vol 42 (5) ◽  
pp. 441-452 ◽  
Author(s):  
Maria Andersson ◽  
Lena Karlsson ◽  
Per-Arne Svensson ◽  
Erik Ulfhammer ◽  
Mikael Ekman ◽  
...  


2012 ◽  
Vol 160 (4) ◽  
pp. 2040-2051 ◽  
Author(s):  
Baohai Li ◽  
Qing Li ◽  
Liming Xiong ◽  
Herbert J. Kronzucker ◽  
Ute Krämer ◽  
...  


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sunirmal Paul ◽  
Norman J. Kleiman ◽  
Sally A. Amundson

AbstractDue to limitations of available human models for development of gene expression based radiation biodosimetry, many such studies have made use of mouse models. To provide a broad view of the gene expression response to irradiation in the mouse, we have exposed male C57BL/6 mice to 0, 1.5, 3, 6 or 10 Gy of gamma rays, sacrificing groups of the mice at 1, 2, 3, 5, or 7 days after exposure. We then profiled global gene expression in blood from individual mice using Agilent microarrays. In general, we found increasing numbers of genes differentially expressed with increasing dose, with more prolonged responses after the higher doses. Gene ontology analysis showed a similar pattern, with more biological processes enriched among the genes responding to higher doses, and at later times after exposure. Clustering the timecourse expression data using maSigPro identified four broad patterns of response, representing different gene ontology functions. The largest of these clusters included genes with initially decreased expression followed by increased expression at later times, a pattern of expression previously reported for several genes following neutron exposure. Another gene cluster showing consistent down regulation suggests genes useful for biodosimetry throughout the first week after exposure can be identified.



2018 ◽  
Vol 189 (4) ◽  
pp. 337 ◽  
Author(s):  
Nils Rudqvist ◽  
Evagelia C. Laiakis ◽  
Shanaz A. Ghandhi ◽  
Suresh Kumar ◽  
Jeffrey D. Knotts ◽  
...  




2011 ◽  
Vol 55 (10) ◽  
pp. 1466-1474 ◽  
Author(s):  
Yvonne G. J. van Helden ◽  
Roger W. L. Godschalk ◽  
Johannes von Lintig ◽  
Georg Lietz ◽  
Jean-Francois Landrier ◽  
...  


2020 ◽  
Vol 267 ◽  
pp. 115483
Author(s):  
Marco Gerdol ◽  
Andrea Visintin ◽  
Sara Kaleb ◽  
Francesca Spazzali ◽  
Alberto Pallavicini ◽  
...  


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