Bennu's Natural Sample Delivery Mechanism: Estimating the Flux of Bennuid Meteors at Earth

Universal immunization of children against common vaccine preventable diseases is the most important aspect of childcare programs. It has long been a goal of the Universal Immunization Program. National Population Policy, 2000 has also stressed on development of Indian Immunization Program, as India is one of the largest in the world, in terms of quantities of vaccines used, numbers of beneficiaries, and the numbers of immunization sessions organized. This program is spread all across the country and seven vaccines are used to protect children and pregnant mothers against tuberculosis, diphtheria, pertusis, polio, measles tetanus and hepatitis-B. Some other supplements like vitamin A and iron tablets have also been added with this delivery mechanism to support overall nutritional level of children and their mothers. To assess the grassroot level condition, this study has tried to explore and compare the different parameters related to routine vaccination and supplement distribution in some selected districts. Role of ASHAs and ANMs is very important for this whole immunization program and to enhance the coverage in qualitative manner, certain evaluation parameters must be established like how many households are aware of sanitation, hygiene, preventive health and healthy lifestyle through ASHA and ANM work.

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Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery

Current Gene Therapy ◽

10.2174/1566523220999200731011702 ◽

2020 ◽

Vol 20 (3) ◽

pp. 195-206 ◽

Cited By ~ 1

Author(s):

Shriya Agarwal ◽

Vinayak Agarwal ◽

Mugdha Agarwal ◽

Manisha Singh

Keyword(s):

Drug Delivery ◽

Gene Therapy ◽

Immune Responses ◽

Biological Membrane ◽

Gene Isolation ◽

Delivery Vehicle ◽

Scientific Communities ◽

Therapeutic Regime ◽

Targeted Gene Therapy ◽

Delivery Mechanism

Abstract: In recent times, several approaches for targeted gene therapy (GT) had been studied. However, the emergence of extracellular vesicles (EVs) as a shuttle carrying genetic information between cells has gained a lot of interest in scientific communities. Owing to their higher capabilities in dealing with short sequences of nucleic acid (mRNA, miRNA), proteins, recombinant proteins, exosomes, the most popular form of EVs are viewed as reliable biological therapeutic conveyers. They have natural access through every biological membrane and can be employed for site-specific and efficient drug delivery without eliciting any immune responses hence, qualifying as an ideal delivery vehicle. Also, there are many research studies conducted in the last few decades on using exosome-mediated gene therapy into developing an effective therapy with the concept of a higher degree of precision in gene isolation, purification and delivery mechanism loading, delivery and targeting protocols. This review discusses several facets that contribute towards developing an efficient therapeutic regime for gene therapy, highlighting limitations and drawbacks associated with current GT and suggested therapeutic regimes.

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Natural and Nanotechnology based Treatment: An Alternative Approach to Psoriasis

Current Nanomedicine ◽

10.2174/2468187310999201022192318 ◽

2020 ◽

Vol 10 ◽

Author(s):

Nishu Yadav ◽

Rohan Aggarwal ◽

Monika Targhotra ◽

P. K Sahoo ◽

Meenakshi K. Chauhan

Keyword(s):

Signs And Symptoms ◽

Lipid Nanoparticles ◽

Medicinal Products ◽

Herbal Medicinal Products ◽

Alternative Approach ◽

The World ◽

Herbal Medicinal ◽

Delivery Mechanism ◽

Dosage Frequency ◽

Dose Reductions

Abstract:: Psoriasis is an autoimmune disease of the skin that is chronic, inflammatory, recurring, and affects about 2-5 percent of the population of the world. For treating psoriasis, ample drugs and molecules are available. However, none are safe and efficient for treating the disease without sacrificing the compliance of the patient. Also, existing medications are intended to mitigate the signs and symptoms and 100% cure is not achieved. They do, however, concentrate on treating the illness and relieving the symptoms. Therefore, finding a delivery mechanism that can treat psoriasis safely and efficiently without sacrificing patient enforcement remains a critical task. Nano based formulations present a high prospect of overcoming the weakness of traditional formulations by providing dose reductions, reduced side effects, and dosage frequency with improved efficacy while herbal medicinal products can also be used as potential drugs against psoriasis as they are easily available and are safe. This review focuses primarily on the traditional strategies and recent discoveries of a range of anti-psoriatic drugs in metallic, polymer, and herbal-based formulations. Nanocarriers such as nanoparticles, dendrimers, micelles, nano-capsules, solid lipid nanoparticles (SLN), ethosome, liposomes have been elaborated. Also, studies relating to the use of phyto based plants in psoriasis has been discussed. Nano and herbal based formulations, in a nutshell, remain known as a promising approach for treating psoriasis.

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Cloning, heterologous expression, and characterization of a novel thioesterase from natural sample

Heliyon ◽

10.1016/j.heliyon.2021.e06542 ◽

2021 ◽

Vol 7 (3) ◽

pp. e06542

Author(s):

Suharti ◽

Gita Mahardika ◽

Raissa ◽

Laksmi Dewi ◽

Heni Yohandini ◽

...

Keyword(s):

Heterologous Expression ◽

Natural Sample

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Using the WWW as the delivery mechanism for interactive, visulaization-based instructional modules

ACM SIGCUE Outlook ◽

10.1145/274382.274380 ◽

1997 ◽

Vol 25 (4) ◽

pp. 13-26 ◽

Cited By ~ 1

Author(s):

Thomas Naps ◽

Joseph Bergin ◽

Ricardo Jiménez-Peris ◽

Myles F. McNally ◽

Marta Patiño-Martínez ◽

...

Keyword(s):

Delivery Mechanism

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Modelling and Analysis of a Grout Delivery Mechanism in the Remote Spray Lining of Shafts

Volume 3: 22nd Design Automation Conference ◽

10.1115/96-detc/dac-1445 ◽

1996 ◽

Author(s):

Liu Hongzhao ◽

E. Appleton

Keyword(s):

Relative Velocity ◽

Viscous Friction ◽

Emission Angle ◽

Inertia Force ◽

Viscous Damping ◽

Friction Forces ◽

Viscous Friction Force ◽

Full Discussion ◽

Delivery Mechanism ◽

Driving Torque

Abstract A thorough analysis on the characteristics of a grout delivery mechanism in the lining of shafts has been accomplished. The dynamic equation of this spraying mechanism has been established and can describe the system’s performance properties under different conditions of viscous friction forces. The analysis introduces a combined viscous damping coefficient c* and a ratio λ between viscous friction force and inertia force. It is proved theoretically that the relative velocity of the grout is less than the implicate velocity and the emission angle α described in the paper is always larger than 45 °. Numerical simulations are performed by feeding various different parameters into the model. A full discussion of the effects of different variables is presented. Additionally, a formula for calculating the driving torque and power is developed. These studies provide an understanding of the properties of this mechanism and should prove useful in guiding its design and operation.

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