scholarly journals Integration of multiomic annotation data to prioritize and characterize inflammation and immune‐related risk variants in squamous cell lung cancer

2020 ◽  
Author(s):  
Ryan Sun ◽  
Miao Xu ◽  
Xihao Li ◽  
Sheila Gaynor ◽  
Hufeng Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Squamous Cell Lung Cancer ◽  
Annotation Data ◽  
Risk Variants ◽  
Related Risk

scholarly journals Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 394
Author(s):  
Nazlisadat Seyed Seyed Khoei ◽  
Robert Carreras-Torres ◽  
Neil Murphy ◽  
Marc J. Gunter ◽  
Paul Brennan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Hodgkin’S Lymphoma ◽  
Mendelian Randomization ◽  
Hodgkin's Lymphoma ◽  
Squamous Cell Lung Cancer ◽  
Phenotypic Variance ◽  
A Genome

Bilirubin, an endogenous antioxidant, may play a protective role in cancer development. We applied two-sample Mendelian randomization to investigate whether genetically raised bilirubin levels are causally associated with the risk of ten cancers (pancreas, kidney, endometrium, ovary, breast, prostate, lung, Hodgkin’s lymphoma, melanoma, and neuroblastoma). The number of cases and their matched controls of European descent ranged from 122,977 and 105,974 for breast cancer to 1200 and 6417 for Hodgkin’s lymphoma, respectively. A total of 115 single-nucleotide polymorphisms (SNPs) associated (p < 5 × 10−8) with circulating total bilirubin, extracted from a genome-wide association study in the UK Biobank, were used as instrumental variables. One SNP (rs6431625) in the promoter region of the uridine-diphosphoglucuronate glucuronosyltransferase1A1 (UGT1A1) gene explained 16.9% and the remaining 114 SNPs (non-UGT1A1 SNPs) explained 3.1% of phenotypic variance in circulating bilirubin levels. A one-standarddeviation increment in circulating bilirubin (≈ 4.4 µmol/L), predicted by non-UGT1A1 SNPs, was inversely associated with risk of squamous cell lung cancer and Hodgkin’s lymphoma (odds ratio (OR) 0.85, 95% confidence interval (CI) 0.73–0.99, P 0.04 and OR 0.64, 95% CI 0.42–0.99, p 0.04, respectively), which was confirmed after removing potential pleiotropic SNPs. In contrast, a positive association was observed with the risk of breast cancer after removing potential pleiotropic SNPs (OR 1.12, 95% CI 1.04–1.20, p 0.002). There was little evidence for robust associations with the other seven cancers investigated. Genetically raised bilirubin levels were inversely associated with risk of squamous cell lung cancer as well as Hodgkin’s lymphoma and positively associated with risk of breast cancer. Further studies are required to investigate the utility of bilirubin as a low-cost clinical marker to improve risk prediction for certain cancers.

scholarly journals Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer

2008 ◽  
Vol 7 (1) ◽  
pp. 62 ◽  
Author(s):  
Paul P Anglim ◽  
Janice S Galler ◽  
Michael N Koss ◽  
Jeffrey A Hagen ◽  
Sally Turla ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Methylation ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Squamous Cell Lung Cancer

scholarly journals Pembrolizumab‐induced pancytopenia in a patient with squamous cell lung cancer

2020 ◽  
Vol 11 (9) ◽  
pp. 2731-2735 ◽  
Author(s):  
Yuriko Ueki ◽  
Manabu Suzuki ◽  
Yuriko Horikawa ◽  
Hiromu Watanabe ◽  
Yoh Yamaguchi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Squamous Cell Lung Cancer

scholarly journals TORAKOCHIRURGIA DNA ploidy as an independent prognostic factor: 10-year results in a group of patients surgically treated for squamous cell lung cancer

2012 ◽  
Vol 3 ◽  
pp. 327-333 ◽  
Author(s):  
Mariusz Kasprzyk ◽  
Wojciech Dyszkiewicz ◽  
Magdalena Roszak ◽  
Rafał Rutkowski ◽  
Cezary Piwkowski ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Prognostic Factor ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Dna Ploidy ◽  
Independent Prognostic Factor ◽  
Squamous Cell Lung Cancer

High-Dose Rate Brachytherapy Has a Curative Potential in Patients with Intraluminal Squamous Cell Lung Cancer

Respiration ◽  
1994 ◽  
Vol 61 (3) ◽  
pp. 167-168 ◽  
Author(s):  
G. Sutedja ◽  
G. Baris ◽  
N. van Zandwijk ◽  
P.E. Postmus
Keyword(s):  
Lung Cancer ◽  
Dose Rate ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
High Dose Rate ◽  
Squamous Cell Lung Cancer ◽  
High Dose ◽  
High Dose Rate Brachytherapy

scholarly journals Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice

2016 ◽  
Vol 113 (27) ◽  
pp. 7614-7619 ◽  
Author(s):  
Yu-bing Dai ◽  
Yi-fei Miao ◽  
Wan-fu Wu ◽  
Yu Li ◽  
Francesca D'Errico ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Squamous Metaplasia ◽  
Inflammatory Cells ◽  
Squamous Cell Lung Cancer ◽  
Alveolar Wall ◽  
Sequencing Analysis ◽  
Thyroid Transcription Factor 1 ◽  
M1 Macrophage

The etiology of peripheral squamous cell lung cancer (PSCCa) remains unknown. Here, we show that this condition spontaneously develops in mice in which the genes for two oxysterol receptors, Liver X Receptor (LXR) α (Nr1h3) and β (Nr1h2), are inactivated. By 1 y of age, most of these mice have to be euthanized because of severe dyspnea. Starting at 3 mo, the lungs of LXRα,βDko mice, but not of LXRα or LXRβ single knockout mice, progressively accumulate foam cells, so that by 1 y, the lungs are covered by a “golden coat.” There is infiltration of inflammatory cells and progressive accumulation of lipid in the alveolar wall, type 2 pneumocytes, and macrophages. By 14 mo, there are three histological lesions: one resembling adenomatous hyperplasia, one squamous metaplasia, and one squamous cell carcinoma characterized by expression of transformation-related protein (p63), sex determining region Y-box 2 (Sox2), cytokeratin 14 (CK14), and cytokeratin 13 (CK13) and absence of thyroid transcription factor 1 (TTF1), and prosurfactant protein C (pro-SPC). RNA sequencing analysis at 12 mo confirmed a massive increase in markers of M1 macrophages and lymphocytes. The data suggest a previously unidentified etiology of PSCCa: cholesterol dysregulation and M1 macrophage-predominant lung inflammation combined with damage to, and aberrant repair of, lung tissue, particularly the peripheral parenchyma. The results raise the possibility that components of the LXR signaling may be useful targets in the treatment of PSCCa.

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