Perceived threat of Alzheimer's disease and related dementias in Chinese older adults: The role of knowledge and perceived stigma

2019 ◽  
Vol 35 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Ms Xiang Gao ◽  
Mr Xiang Gao ◽  
Lin Guo ◽  
Fei Sun ◽  
Anao Zhang
2020 ◽  
pp. 1-17
Author(s):  
Xiang Gao ◽  
Fei Sun ◽  
Lucas Prieto ◽  
Vijeth Iyengar

Abstract In mainland China, as the population ages, Alzheimer's disease and related dementia (ADRD) is estimated to increase among Chinese older adults. Chinese older adults tend to hold stigmatising beliefs about ADRD that in turn affect their help-seeking behaviour and receipt of prevention and treatment. The Framework Integrating Normative Influences on Stigma provides a rationale for Chinese older adult's stigma about ADRD. Questionnaires were administered in person to 754 older adults (42% male, mean age = 69.54 years) from two urban communities in mainland China. We examined ADRD stigma and the associations with real-life exposure, knowledge of ADRD, health conditions and social networks. This study found that Chinese older adults who had good family quality, lower depression (as measured by the Center for Epidemiological Studies Depression Scale) and better cognitive health (as measured by the Montreal Cognitive Assessment) were more likely to have lower perceived stigma. Conversely, those individuals who experienced neglect and had more ADRD knowledge exhibited higher levels of perceived stigma. Social networks moderated the associations between cognitive scores and perceived stigma. This research suggested that the quality of one's social networks is essential to reduce perceived stigma among Chinese older adults. Future research should continue to explore ADRD stigma among Chinese older adults to help guide relevant interventions, services and supports for this population.


2015 ◽  
Vol 4 (1) ◽  
pp. 28-38 ◽  
Author(s):  
Jennifer L. Etnier

Alzheimer's disease is a chronic illness characterized by clinical cognitive impairment. A behavioral strategy that is being explored in the prevention of Alzheimer's disease is physical activity. Evidence from randomized controlled trials (RCTs) testing the effects of physical activity for cognitively normal older adults supports that physical activity benefits cognitive performance. Evidence from prospective studies supports a protective effect of physical activity with reductions in the risk of cognitive decline ranging from 28% to 45%. RCTs with cognitively impaired older adults also generally support positive effects with greater benefits evident for aerobic interventions. Research examining the potential moderating role of apolipoprotein E (APOE) has yielded mixed results, but the majority of the studies support that physical activity most benefits those who are at greatest genetic risk of Alzheimer's disease. Future directions for research are considered with an emphasis on the need for additional funding to support this promising area of research.


2017 ◽  
Vol 33 (2) ◽  
pp. 122-130
Author(s):  
Eunsaem Kim ◽  
Sarah Ullrich-French ◽  
Cory Bolkan ◽  
Laura Griner Hill

2021 ◽  
Vol 19 ◽  
Author(s):  
Xin-Zhu Yan ◽  
Laijun Lai ◽  
Qiang Ao ◽  
Xiao-hong Tian ◽  
Yan-hui Zhang

: Alzheimer’s disease (AD) is a progressive neurodegenerative disease which mainly affects older adults. Although the global burden of AD is increasing year by year, the causes of AD remain largely unknown. Numerous basic and clinical studies have shown that interleukin-17A (IL-17A) may play a significant role in the pathogenesis of AD. A comprehensive assessment ofthe role of IL-17A in AD would benefit the diagnosis, understanding of etiology and treatment. However, over the past decade controversies remain regarding the expression level and role of IL-17A in AD. We have incorporated newly published researches and point out that IL-17A expression levels may vary along with the development of AD, exercising different roles at different stages of AD, although much more work remains to be done to support the potential role of IL-17A in AD-related pathology.Here, it is our intention to review the underlying mechanisms of IL-17A in AD and address the current controversies, in an effort to clarify the results of existing research and suggest future studies.


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