Quantitative CT scan analysis in senile dementia of the Alzheimer type: II. Radioattentuation of grey and white matter

SummaryComputed cranial tomography was performed on 48 patients with Senile Dementia of the Alzheimer Type (SDAT) who have since been followed up in a continuing prospective study. At six-months follow-up, ten patients had died; these did not differ significantly from the survivors either in mean age or duration of dementia, although the latter tended to have been shorter in the deceased. Despite having shorter histories, the deceased had performed worse on initial testing with several cognitive measures, and this was significant for the mental test score; this suggests some patients may have a more rapidly progressive form of SDAT. In a comparison between the CT scan of the deceased and survivors, the deceased were found to have significantly lower mean attenuation densities in the parietal, occipital, and left thalamic regions. The hypothesis that low attenuation density in the parietal regions of the CT scan in SDAT is associated with a more rapid demise is supported for the present period of follow-up.

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Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging

Neurology ◽

10.1212/wnl.37.8.1365 ◽

1987 ◽

Vol 37 (8) ◽

pp. 1365-1365 ◽

Cited By ~ 110

Author(s):

D. L. Rezek ◽

J. C. Morris ◽

K. H. Fulling ◽

M. H. Gado

Keyword(s):

White Matter ◽

Senile Dementia ◽

Normal Aging ◽

Periventricular White Matter ◽

Alzheimer Type ◽

Senile Dementia Of The

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Membrane Components Separate Early-Onset Alzheimer's Disease From Senile Dementia of the Alzheimer Type

International Psychogeriatrics ◽

10.1017/s1041610296002736 ◽

1996 ◽

Vol 8 (3) ◽

pp. 365-372 ◽

Cited By ~ 52

Author(s):

Carl-Gerhard Gottfries ◽

Ingvar Karlsson ◽

Lars Svennerholm

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

White Matter ◽

Brain Tissue ◽

Membrane Lipids ◽

Senile Dementia ◽

Alzheimer Type ◽

Synapse Degeneration ◽

Membrane Components ◽

Senile Dementia Of The

Brain tissue from 12 subjects with pure Alzheimer's disease (AD) and 21 subjects with senile dementia of the Alzheimer type (SDAT) was investigated for membrane lipids and compared with that in age-matched controls. In brain tissue from the patients with AD, phospholipids were significantly decreased compared with that from SDAT patients and controls, cholesterol was reduced compared with that in controls, and gangliosides were significantly reduced in all gray-matter areas investigated compared with those in both SDAT subjects and controls. A reduction in gangliosides also occurred in the SDAT group, but it was smaller. In the white matter, the pattern of changes was the opposite. Phospholipids, cholesterol, cerebroside, and sulfatide were significantly reduced in the frontal-lobe white matter in the SDAT group compared with that in age-matched controls and AD patients. Gangliosides in the cerebrospinal fluid also separated AD from SDAT and controls. The findings indicate synapse degeneration as an important pathogenetic factor in AD. This disorder should be separated from SDAT, in which white-matter degeneration appears to be more prominent.

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Magnetic resonance imaging in pre-senile dementia of the Alzheimer-type, multi-infarct dementia and Korsakoff's syndrome

Psychological Medicine ◽

10.1017/s0033291700007868 ◽

1988 ◽

Vol 18 (2) ◽

pp. 319-329 ◽

Cited By ~ 31

Author(s):

J. E. Christie ◽

D. M. Kean ◽

R. H. B. Douglas ◽

H. M. Engleman ◽

D. St. Clair ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Differential Diagnosis ◽

White Matter ◽

Magnetic Resonance ◽

Senile Dementia ◽

Resonance Imaging ◽

Alzheimer Type ◽

Korsakoff’S Syndrome ◽

Korsakoff's Syndrome ◽

Senile Dementia Of The

SynopsisMagnetic resonance imaging T1 values in Alzheimer's disease (ATD) were similar to age-matched controls although frontal T1 values tended to increase intraindividually with progression of the dementia. T1 values were raised, in both cortical grey and white matter, in Korsakoff's syndrome and multi-infarct dementia. T1 values appear of little value in studying the neuropathological changes in ATD in relationship to the neuropsychological deficits, but can assist in the differential diagnosis of pre-senile dementia.

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