Molecular-cytogenetic characterization of head and neck cancer: Identification of novel prognostic factors and gene targets for therapy

Head & Neck ◽  
2006 ◽  
Vol 29 (1) ◽  
pp. 82-83
Author(s):  
Robert L. Ferris
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Neck Cancer ◽  
Molecular Cytogenetic ◽  
Cytogenetic Characterization

scholarly journals Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival

2020 ◽  
Author(s):  
Lars Axelsson ◽  
Erik Holmberg ◽  
Jan Nyman ◽  
Anders Högmo ◽  
Helena Sjödin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Multicenter Study ◽  
Performance Status ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
N Stage

Abstract Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPV-positive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p= 0.036), and N stage (p= 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and (chemo) radiation and primary (chemo) radiation gave similar survival outcomes. A randomized treatment study that includes quality of life is needed to establish the optimal treatment.

Prognosis in Head and Neck Cancer: Importance of Nutritional and Biological Inflammatory Status

2021 ◽  
pp. 019459982110045
Author(s):  
Nicolas Saroul ◽  
Mathilde Puechmaille ◽  
Céline Lambert ◽  
Achraf Sayed Hassan ◽  
Julian Biau ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Inflammatory Response ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Risk Index ◽  
Nutritional Risk ◽  
Inflammatory Status ◽  
Nutritional Risk Index

Objectives To determine the importance of nutritional status, social status, and inflammatory status in the prognosis of head and neck cancer. Study Design Single-center retrospective study of prospectively collected data. Setting Tertiary referral center. Methods Ninety-two consecutive patients newly diagnosed for cancer of the upper aerodigestive tract without metastases were assessed at time of diagnosis for several prognostic factors. Nutritional status was assessed by the nutritional risk index, social status by the EPICES score, and inflammatory status by the systemic inflammatory response index. The primary endpoint was overall survival. Results In multivariable analysis, the main prognostic factors were the TNM classification (hazard ratio [HR] = 3.34, P = .002, for stage T3-4), malnutrition as assessed by the nutritional risk index (HR = 3.64, P = .008, for severe malnutrition), and a systemic inflammatory response index score ≥1.6 (HR = 3.32, P = .02). Social deprivation was not a prognostic factor. Conclusion Prognosis in head and neck cancer is multifactorial; however, malnutrition and inflammation are important factors that are potentially reversible by early intervention.

scholarly journals Characterization of changes in total body composition for patients with head and neck cancer undergoing chemoradiotherapy using dual-energy x-ray absorptiometry

Head & Neck ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
William Jackson ◽  
Neil Alexander ◽  
Matthew Schipper ◽  
Lorraine Fig ◽  
Felix Feng ◽  
...  
Keyword(s):  
Body Composition ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Dual Energy ◽  
X Ray ◽  
Total Body Composition ◽  
Total Body

140 Prognostic factors of overall survival for patients with recurrent head and neck cancer: a retrospective study

2003 ◽  
Vol 1 (5) ◽  
pp. S46
Author(s):  
L. Chaigneau ◽  
T. Nguyen ◽  
U. Stein ◽  
E. Guardiola ◽  
A. Danzon ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Retrospective Study ◽  
Head And Neck ◽  
Neck Cancer ◽  
Recurrent Head

Prognostic factors for lymphedema in patients with locally advanced head and neck cancer after combined radio(chemo)therapy- results of a longitudinal study

Oral Oncology ◽  
2020 ◽  
Vol 109 ◽  
pp. 104856
Author(s):  
Silke Tribius ◽  
Henning Pazdyka ◽  
Pierre Tennstedt ◽  
Chia-Jung Busch ◽  
Henning Hanken ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Longitudinal Study ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head

scholarly journals Prognostic factors associated with a restricted mouth opening (trismus) in patients with head and neck cancer: Systematic review

Head & Neck ◽  
2020 ◽  
Vol 42 (9) ◽  
pp. 2696-2721 ◽  
Author(s):  
Sarah J. Geer ◽  
Phillip V. Rijn ◽  
Jan L.N. Roodenburg ◽  
Pieter U. Dijkstra
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Neck Cancer ◽  
Mouth Opening ◽  
Factors Associated

scholarly journals Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass

Oral Oncology ◽  
2019 ◽  
Vol 98 ◽  
pp. 53-61 ◽  
Author(s):  
Anne M. van Harten ◽  
Jos B. Poell ◽  
Marijke Buijze ◽  
Arjen Brink ◽  
Susanne I. Wells ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cell Line ◽  
Neck Cancer ◽  
Copy Number ◽  
Cell Line Panel
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