The impact of worst pattern of invasion on the extension of surgical margins in oral squamous cell carcinoma

Head & Neck ◽  
2021 ◽  
Author(s):  
Hugo Fontan Köhler ◽  
José Guilherme Vartanian ◽  
Clóvis Antônio Lopes Pinto ◽  
Ivete Fabelo Pereira Silva Rodrigues ◽  
Luiz Paulo Kowalski
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margins ◽  
Pattern Of Invasion ◽  
The Impact ◽  
Worst Pattern Of Invasion

The Impact of Surgical Margins of Oral Squamous Cell Carcinoma on Local Recurrence and Disease-Specific Survival

2013 ◽  
Vol 71 (9) ◽  
pp. e76-e77
Author(s):  
T. Smoot ◽  
K. Pennau ◽  
T. McDonald ◽  
C. Brown ◽  
N. Futran ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Local Recurrence ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margins ◽  
Disease Specific Survival ◽  
The Impact ◽  
Disease Specific

scholarly journals The impact of close surgical margins on recurrence in oral squamous cell carcinoma

2021 ◽  
Vol 50 (1) ◽  
Author(s):  
Joseph Solomon ◽  
Ashley Hinther ◽  
T. Wayne Matthews ◽  
Steven C. Nakoneshny ◽  
Rob Hart ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cox Regression ◽  
Tumour Size ◽  
Surgical Margins ◽  
Smoking History ◽  
Cox Regression Analysis ◽  
The Impact

Abstract Background Close margins influence treatment and outcome in patients with oral squamous cell carcinoma (OSCC). This study evaluates 187 cases of surgically treated OSCC regarding the impact of close margins on recurrence-free survival (RFS) and disease-specific survival (DSS). Methods Predictors of worsened outcome were identified using Kaplan-Meier analysis and multivariate Cox regression analysis. Results Tumour size [HR:1.70(0.95–3.08)], nodal status [HR:2.15(1.00–4.64)], presence of extracapsular spread (ECS) [HR:6.36(2.41–16.74)] and smoking history [HR:2.87(1.19–6.86)] were associated with worsened RFS. Similar factors were associated with worsened DSS. Close margins did not influence RFS or DSS. Conclusions While most conventional risk factors for OSCC conferred a worsened outcome, close margins did not. One explanation for this would be that close margins (< 5 mm) are equivalent to clear margins and the cutoff definition for a close margin should be re-evaluated. Lack of standardized pathology could also reduce accuracy of reporting of close surgical margins. Graphical abstract

scholarly journals DNA Methylation Markers from Negative Surgical Margins Can Predict Recurrence of Oral Squamous Cell Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2915
Author(s):  
Bruna Pereira Sorroche ◽  
Fazlur Rahman Talukdar ◽  
Sheila Coelho Soares Lima ◽  
Matias Eliseo Melendez ◽  
Ana Carolina de Carvalho ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Recurrence ◽  
Surgical Margins ◽  
Risk Scores ◽  
Marker Panel ◽  
Specificity And Sensitivity

The identification of molecular markers in negative surgical margins of oral squamous cell carcinoma (OSCC) might help in identifying residual molecular aberrations, and potentially improve the prediction of prognosis. We performed an Infinium MethylationEPIC BeadChip array on 32 negative surgical margins stratified based on the status of tumor recurrence in order to identify recurrence-specific aberrant DNA methylation (DNAme) markers. We identified 2512 recurrence-associated Differentially Methylated Positions (DMPs) and 392 Differentially Methylated Regions (DMRs) which were enriched in cell signaling and cancer-related pathways. A set of 14-CpG markers was able to discriminate recurrent and non-recurrent cases with high specificity and sensitivity rates (AUC 0.98, p = 3 × 10−6; CI: 0.95–1). A risk score based on the 14-CpG marker panel was applied, with cases classified within higher risk scores exhibiting poorer survival. The results were replicated using tumor-adjacent normal HNSCC samples from The Cancer Genome Atlas (TCGA). We identified residual DNAme aberrations in the negative surgical margins of OSCC patients, which could be informative for patient management by improving therapeutic intervention. This study proposes a novel DNAme-based 14-CpG marker panel as a promising predictor for tumor recurrence, which might contribute to improved decision-making for the personalized treatment of OSCC cases.

P-97 The impact of tobacco smoking on survival for patients with oral squamous cell carcinoma: a population-based retrospective study

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 12
Author(s):  
Amanda Oester Andersen ◽  
Jakob Schmidt Jensen ◽  
Kathrine Kronberg Jakobsen ◽  
Helene Stampe ◽  
Kristoffer Juul Nielsen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tobacco Smoking ◽  
Population Based ◽  
The Impact

P-96 The impact of tobacco smoking on survival for patients with oral squamous cell carcinoma: a population-based retrospective study

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 11
Author(s):  
Amanda Oester Andersen ◽  
Jakob Schmidt Jensen ◽  
Kathrine Kronberg Jakobsen ◽  
Helene Stampe ◽  
Kristoffer Juul Nielsen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tobacco Smoking ◽  
Population Based ◽  
The Impact

scholarly journals Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma

2010 ◽  
Vol 52 (3) ◽  
pp. 417-424 ◽  
Author(s):  
Satiro Watanabe ◽  
Rogério Watanabe ◽  
Angélica F. Oton-Leite ◽  
Rita de C. G. Alencar ◽  
José C. Oliveira ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pattern Of Invasion

Evaluation of autofluorescence visualization system in the delineation of oral squamous cell carcinoma surgical margins

2021 ◽  
pp. 102487
Author(s):  
Li-Fan Sun ◽  
Chen-Xing Wang ◽  
Zheng-Yao Cao ◽  
Wei Han ◽  
Song-Song Guo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margins ◽  
Visualization System

Impact of dysplastic surgical margins for patients with oral squamous cell carcinoma

Oral Oncology ◽  
2019 ◽  
Vol 97 ◽  
pp. 1-6 ◽  
Author(s):  
Tseng-Cheng Chen ◽  
Huei-Lun Chang ◽  
Tsung-Lin Yang ◽  
Pei-Jen Lou ◽  
Yih-Leong Chang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margins
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