Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro

Hepatology ◽  
1994 ◽  
Vol 20 (2) ◽  
pp. 376-382 ◽  
Author(s):  
Koshi Matsumoto ◽  
Hiroaki Fujii ◽  
George Michalopoulos ◽  
John J. Fung ◽  
Anthony J. Demetris
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Dna Synthesis ◽  
Interleukin 6 ◽  
Hepatocyte Growth Factors ◽  
Epidermal Growth ◽  
Hepatocyte Growth

scholarly journals Inhibition of DNA synthesis by somatostatin in rat hepatocytes stimulated by hepatocyte growth factor or epidermal growth factor

1992 ◽  
Vol 163 (1) ◽  
pp. 169-173 ◽  
Author(s):  
Norihiro Kokudo ◽  
]Piyush C. Kothary ◽  
Frederic E. Eckhauser ◽  
Toshikazu Nakamura ◽  
Steven E. Raper
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Dna Synthesis ◽  
Rat Hepatocytes ◽  
Epidermal Growth ◽  
Inhibition Of Dna Synthesis ◽  
Hepatocyte Growth

Kinetics of hepatocyte growth factor-induced DNA synthesis in vitro

1993 ◽  
Vol 5 (6) ◽  
pp. 451-456
Author(s):  
Anthony C. Woodman ◽  
Jane Collard ◽  
Clare Selden ◽  
Humphrey J.F. Hodgson
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Dna Synthesis ◽  
Kinetics Of ◽  
Hepatocyte Growth

scholarly journals Sustained increase in 1,2-diacylglycerol precedes DNA synthesis in epidermal-growth-factor-stimulated fibroblasts. Evidence for stimulated phosphatidylcholine hydrolysis

1990 ◽  
Vol 267 (2) ◽  
pp. 501-507 ◽  
Author(s):  
T M Wright ◽  
H S Shin ◽  
D M Raben
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Dna Synthesis ◽  
De Novo ◽  
Phospholipid Metabolism ◽  
Intracellular Signals ◽  
Mitogenic Signalling ◽  
Epidermal Growth ◽  
Hydrolysis Of

A property common to many growth factors is that they must be present for several hours before the commitment to DNA synthesis and cell division occurs. The intracellular signals that are relevant during this period are poorly defined. We examined the formation of 1,2-diacylglycerol in IIC9 fibroblasts after stimulation with epidermal growth factor (EGF), and found that the mass of this lipid remained elevated for at least four hours. The concentration-dependence of EGF-stimulated 1,2-diacylglycerol production and [3H]thymidine incorporation were similar. Studies of phospholipid metabolism strongly suggested that phosphatidylcholine was the source of the 1,2-diacylglycerol generated in response to EGF. EGF did not stimulate the hydrolysis of other phospholipids, including the phosphoinositides, nor did it increase synthesis de novo of 1,2-diacylglycerol. This pattern of sustained 1,2-diacylglycerol formation from phosphatidylcholine may be important in the mitogenic signalling of EGF and potentially other growth factors.

scholarly journals Influence of hepatocyte growth factor, epidermal growth factor, and mycophenolic acid on endothelin‐1 synthesis in human endothelial cells

2001 ◽  
Vol 16 (12) ◽  
pp. 2310-2316 ◽  
Author(s):  
Cornelia Haug ◽  
Alexandra Schmid‐Kotsas ◽  
Theresia Linder ◽  
Max G. Bachem ◽  
Adolf Gruenert ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Mycophenolic Acid ◽  
Human Endothelial Cells ◽  
Endothelin 1 ◽  
Epidermal Growth ◽  
Hepatocyte Growth

Inhibitory Effect of Epidermal Growth Factor and Hepatocyte Growth Factor on Endothelin-1 Release by Rabbit Proximal Tubule Cells

2000 ◽  
Vol 36 ◽  
pp. S248-S251 ◽  
Author(s):  
Cornelia Haug ◽  
Theresia M. Linder ◽  
Alexandra Schmid-Kotsas ◽  
Simone Hetzel ◽  
Friedlinde Ernst ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Proximal Tubule ◽  
Inhibitory Effect ◽  
Proximal Tubule Cells ◽  
Endothelin 1 ◽  
Epidermal Growth ◽  
Tubule Cells ◽  
Hepatocyte Growth
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