Lack of an association between an apolipoprotein C3 genetic variant and the liver fat content in patients with type 2 diabetes

Hepatology ◽  
2011 ◽  
Vol 54 (3) ◽  
pp. 1109-1110 ◽  
Author(s):  
Jean Michel Petit ◽  
Boris Guiu ◽  
David Masson ◽  
Jean-Pierre Cercueil ◽  
Patrick Hillon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variant ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Apolipoprotein C3

Diabetes Remission Clinical Trial (DiRECT)—Plasma Liver Function Tests Reflect Change in Liver Fat Content in Early Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1834-P
Author(s):  
SVIATLANA V. ZHYZHNEUSKAYA ◽  
AHMAD AL-MRABEH ◽  
CARL PETERS ◽  
ALISON C. BARNES ◽  
KIEREN G. HOLLINGSWORTH ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Liver Function ◽  
Liver Function Tests ◽  
Fat Content ◽  
Diabetes Remission ◽  
Liver Fat ◽  
Early Type ◽  
Liver Fat Content

scholarly journals A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial

Diabetologia ◽  
2019 ◽  
Vol 62 (11) ◽  
pp. 2066-2078 ◽  
Author(s):  
Mads J. Skytte ◽  
Amirsalar Samkani ◽  
Amy D. Petersen ◽  
Mads N. Thomsen ◽  
Arne Astrup ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
High Protein Diet ◽  
Fat Content ◽  
Protein Diet ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Randomised Controlled

Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes

2006 ◽  
Vol 291 (2) ◽  
pp. E282-E290 ◽  
Author(s):  
Riikka Lautamäki ◽  
Ronald Borra ◽  
Patricia Iozzo ◽  
Markku Komu ◽  
Terho Lehtimäki ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Liver Steatosis ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Artery Disease ◽  
Myocardial Insulin Resistance ◽  
High Liver

Nonalcoholic fatty liver (NAFL) is a common comorbidity in patients with type 2 diabetes and links to the risk of coronary syndromes. The aim was to determine the manifestations of metabolic syndrome in different organs in patients with liver steatosis. We studied 55 type 2 diabetic patients with coronary artery disease using positron emission tomography. Myocardial perfusion was measured with [15O]H2O and myocardial and skeletal muscle glucose uptake with 2-deoxy-2-[18F]fluoro-d-glucose during hyperinsulinemic euglycemia. Liver fat content was determined by magnetic resonance proton spectroscopy. Patients were divided on the basis of their median (8%) into two groups with low (4.6 ± 2.0%) and high (17.4 ± 8.0%) liver fat content. The groups were well matched for age, BMI, and fasting plasma glucose. In addition to insulin resistance at the whole body level ( P = 0.012) and muscle ( P = 0.002), the high liver fat group had lower insulin-stimulated myocardial glucose uptake ( P = 0.040) and glucose extraction rate ( P = 0.0006) compared with the low liver fat group. In multiple regression analysis, liver fat content was the most significant explanatory variable for myocardial insulin resistance. In addition, the high liver fat group had increased concentrations of high sensitivity C-reactive protein, soluble forms of E-selectin, vascular adhesion protein-1, and intercellular adhesion molecule-1 ( P < 0.05) and lower coronary flow reserve ( P = 0.02) compared with the low liver fat group. In conclusion, in patients with type 2 diabetes and coronary artery disease, liver fat content is a novel independent indicator of myocardial insulin resistance and reduced coronary functional capacity. Further studies will reveal the effect of hepatic fat reduction on myocardial metabolism and coronary function.

scholarly journals Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial

Diabetes Care ◽  
2019 ◽  
Vol 43 (2) ◽  
pp. 298-305 ◽  
Author(s):  
Sabine Kahl ◽  
Sofiya Gancheva ◽  
Klaus Straßburger ◽  
Christian Herder ◽  
Jürgen Machann ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Controlled Trial ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Double Blind

scholarly journals Liver Fat Content in Type 2 Diabetes: Relationship With Hepatic Perfusion and Substrate Metabolism

Diabetes ◽  
2010 ◽  
Vol 59 (11) ◽  
pp. 2747-2754 ◽  
Author(s):  
L. J. Rijzewijk ◽  
R. W. van der Meer ◽  
M. Lubberink ◽  
H. J. Lamb ◽  
J. A. Romijn ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Hepatic Perfusion ◽  
Substrate Metabolism

GCKR polymorphism influences liver fat content in patients with type 2 diabetes

2015 ◽  
Vol 53 (2) ◽  
pp. 237-242 ◽  
Author(s):  
Jean-Michel Petit ◽  
David Masson ◽  
Boris Guiu ◽  
Fabien Rollot ◽  
Laurence Duvillard ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content
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