scholarly journals Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion

Hepatology ◽  
2014 ◽  
Vol 59 (3) ◽  
pp. 1030-1042 ◽  
Author(s):  
Nisanne S. Ghonem ◽  
Meenakshisundaram Ananthanarayanan ◽  
Carol J. Soroka ◽  
James L. Boyer
Keyword(s):  
Multidrug Resistance ◽  
Atp Binding ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Multidrug Resistance Transporter ◽  
Phosphatidylcholine Secretion ◽  
Atp Binding Cassette

scholarly journals Human Lupus Plasma Pro-Atherogenic Effects on Cultured Macrophages Are Not Mitigated by Statin Therapy: A Mechanistic LAPS Substudy

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 514 ◽  
Author(s):  
Reiss ◽  
Arain ◽  
Kasselman ◽  
Renna ◽  
Zhen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lupus Erythematosus ◽  
Cholesterol Metabolism ◽  
Lipid Lowering ◽  
Cholesterol Transport ◽  
Atp Binding ◽  
Peroxisome Proliferator ◽  
Atherosclerotic Cardiovascular Disease ◽  
Peroxisome Proliferator Activated Receptor ◽  
Atp Binding Cassette

Background and Objectives: Atherosclerotic cardiovascular disease (CVD) remains a major cause of morbidity and mortality in persons with systemic lupus erythematosus (SLE, lupus). Atherosclerosis, which involves interplay between cholesterol metabolism and cellular inflammatory pathways, is primarily treated with statins since statins have lipid-lowering and anti-inflammatory properties. The Lupus Atherosclerosis Prevention Study (LAPS) was designed to investigate the efficacy of statins against CVD in SLE patients. LAPS demonstrated that 2 years of atorvastatin administration did not reduce atherosclerosis progression in lupus patients. In this LAPs substudy, we use cultured macrophages to explore the atherogenic properties of plasma from LAPS subjects to explain the mechanistic rationale for the inability of statins to reduce CVD in lupus. Materials and Methods: THP-1 differentiated macrophages were treated for 18 h with 10% SLE patient plasma obtained pre- and post-atorvastatin therapy or placebo. Gene expression of the following cholesterol transport genes was measured by qRT-PCR. For efflux—ATP binding cassette transporter (ABC)A1 and ABCG1, 27-hydroxylase, peroxisome proliferator-activated receptor (PPAR)γ, and liver X receptor (LXR)α; and for influx—cluster of differentiation 36 (CD36) and scavenger receptor (ScR)A1. Results: Macrophages exposed to plasma from both statin-treated and placebo-treated groups showed a significant decrease in cholesterol efflux proteins ATP binding cassette (ABC) transporters A1 and ABCG1, an increase in 27-hydroxylase, an increase in the LDL receptor and a decrease in intracellular free cholesterol. No change in influx receptors ScRA1 and CD36, nor nuclear proteins LXRα and PPARγ was observed. Conclusions: Statins do not normalize pro-atherogenic changes induced by lupus and these changes continue to worsen over time. This study provides mechanistic insight into LAPS findings by demonstrating that statins are overall ineffective in altering the balance of cholesterol transport gene expression in human macrophages. Furthermore, our study suggests that statins as a CVD treatment may not be useful in attenuating lipid overload in the SLE environment.

scholarly journals HG-829 Is a Potent Noncompetitive Inhibitor of the ATP-Binding Cassette Multidrug Resistance Transporter ABCB1

2012 ◽  
Vol 72 (16) ◽  
pp. 4204-4213 ◽  
Author(s):  
Gisela Caceres ◽  
Robert W. Robey ◽  
Lubomir Sokol ◽  
Kathy L. McGraw ◽  
Justine Clark ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Atp Binding ◽  
Noncompetitive Inhibitor ◽  
Multidrug Resistance Transporter ◽  
Atp Binding Cassette

scholarly journals Enhanced Multispecificity ofArabidopsisVacuolar Multidrug Resistance-associated Protein-type ATP-binding Cassette Transporter, AtMRP2

2000 ◽  
Vol 276 (12) ◽  
pp. 8648-8656 ◽  
Author(s):  
Guosheng Liu ◽  
Rocı́o Sánchez-Fernández ◽  
Ze-Sheng Li ◽  
Philip A. Rea
Keyword(s):  
Multidrug Resistance ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette
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