Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease

2012 ◽  
Vol 18 (1) ◽  
pp. 180-186 ◽  
Author(s):  
Gheorghe Hundorfean ◽  
Markus F. Neurath ◽  
Jonas Mudter
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Th17 Cells ◽  
T Helper ◽  
T Helper 17 ◽  
Inflammatory Bowel ◽  
Functional Relevance

Sa1780 Comprehensive T Helper Cell Profiling Reveals Concomitant Upregulation of Regulatory T Cells and TH17 Cells in Active Inflammatory Bowel Disease

2013 ◽  
Vol 144 (5) ◽  
pp. S-304
Author(s):  
Bertram Bengsch ◽  
Anna-Maria Globig ◽  
Nadine Hennecke ◽  
Maximilian Seidl ◽  
Hubert E. Blum ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
Regulatory T Cells ◽  
Bowel Disease ◽  
Th17 Cells ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Active Inflammatory Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Association of SIRT-1, T helper 17-associated gene and Antimicrobial Peptides gene in Inflammatory Bowel Disease Patients

2017 ◽  
Vol 7 (3) ◽  
pp. 196-203
Author(s):  
Magdy Amin El Serafy ◽  
◽  
Dina Sabry ◽  
Mohammed Ahmed Mohey El din ◽  
Ahmed Moustafa ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Antimicrobial Peptides ◽  
Bowel Disease ◽  
T Helper ◽  
T Helper 17 ◽  
Inflammatory Bowel

scholarly journals High Intestinal and Systemic Levels of Interleukin-23/T-Helper 17 Pathway in Chinese Patients with Inflammatory Bowel Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Lu Song ◽  
Rui Zhou ◽  
Sha Huang ◽  
Feng Zhou ◽  
Shufang Xu ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Chinese Population ◽  
Janus Kinase ◽  
Chinese Patients ◽  
Mrna Levels ◽  
T Helper ◽  
T Helper 17 ◽  
Inflammatory Bowel ◽  
Interleukin 23

Interleukin-23/T-helper 17 (IL-23/Th17) pathway plays a key role in the pathogenesis of inflammatory bowel disease (IBD), but little is known about its expression in Chinese population. In this study, we investigated the mRNA and protein levels of IL-12p40, tumor necrosis factor-like cytokine 1A (TL1A), Janus kinase 2 (JAK2), and IL-23R both locally and systemically in Chinese IBD patients. Our results indicated that the mRNA levels of IL-12p40 and TL1A were increased in ulcerative colitis (UC) patients. Furthermore, serum IL-12p40 and TL1A levels were higher in active UC patients, especially in patients with disease course less than 1.25 years or initial onset. No correlation was found between the genotype and serum levels of IL-12p40 or TL1A in UC patients. Additionally, the mRNA and protein expression of JAK2 and IL-23R were increased in UC and Crohn’s disease (CD) patients. Taken together, our results provided evidence that IL-23/Th17 pathway genes may represent important biomarkers of active stage of IBD and serve as novel therapeutic targets for IBD in Chinese population.

scholarly journals Alteration of Interleukin 4 Production Results in the Inhibition of T Helper Type 2 Cell–Dominated Inflammatory Bowel Disease in T Cell Receptor α Chain–Deficient Mice

1999 ◽  
Vol 190 (5) ◽  
pp. 607-616 ◽  
Author(s):  
Hideki Iijima ◽  
Ichiro Takahashi ◽  
Daisuke Kishi ◽  
Jin-Kyung Kim ◽  
Sunao Kawano ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Bowel Disease ◽  
Cell Receptor ◽  
Interleukin 4 ◽  
T Helper ◽  
Inflammatory Bowel ◽  
Α Chain

T cell receptor α chain–deficient (TCR-α−/−) mice are known to spontaneously develop inflammatory bowel disease (IBD). The colitis that develops in these mice is associated with increased numbers of T helper cell (Th)2-type CD4+TCR-ββ (CD4+ββ) T cells producing predominantly interleukin (IL)-4. To investigate the role of these Th2-type CD4+ββ T cells, we treated TCR-α−/− mice with anti–IL-4 monoclonal antibody (mAb). Approximately 60% of TCR-α−/− mice, including those treated with mock Ab and those left untreated, spontaneously developed IBD. However, anti–IL-4 mAb–treated mice exhibited no clinical or histological signs of IBD, and their levels of mucosal and systemic Ab responses were lower than those of mock Ab–treated mice. Although TCR-α−/− mice treated with either specific or mock Ab developed CD4+ββ T cells, only those treated with anti–IL-4 mAb showed a decrease in Th2-type cytokine production at the level of mRNA and protein and an increase in interferon γ–specific expression. These findings suggest that IL-4–producing Th2-type CD4+ββ T cells play a major immunopathological role in the induction of IBD in TCR-α−/− mice, a role that anti–IL-4 mAb inhibits by causing Th2-type CD4+ββ T cells to shift to the Th1 type.

scholarly journals The protective effect of curcumin on rats with DSS-induced ulcerative colitis and its mechanisms

2021 ◽  
Author(s):  
Jing Guo ◽  
Yan-yan Zhang ◽  
Mei Sun ◽  
Ling-fen Xu
Keyword(s):  
Ulcerative Colitis ◽  
Th17 Cells ◽  
Dextran Sulfate ◽  
Activity Index ◽  
Disease Activity Index ◽  
Treg Cells ◽  
Enzyme Linked Immunosorbent Assay ◽  
T Helper ◽  
T Helper 17 ◽  
Inflammatory Bowel

Abstract Aim This study aimed to explore effect of curcumin on inflammatory bowel disease (IBD) in rats and its mechanism.Methods: A dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) rat model was established. The disease activity index (DAI) scores were calculated. The histopathological damage scores were determined by haematoxylin-eosin (H&E) staining. Regulatory T (Treg) cells and T helper 17 (Th17) cells in the spleen were analysed by flow cytometry. The levels of interleukin (IL)-10 and IL-17A were determined by enzyme-linked immunosorbent assay (ELISA). Results: Compared with the DSS model group, the curcumin group exhibited significantly reduced DAI scores and improvements in histopathological damage. The expression of CD4+IL-17+ Th17 cells was significantly lower and the expression of CD4+CD25+Foxp3+ Treg cells was significantly higher in the curcumin group than in the DSS group.Conclusion: Curcumin may be a new and effective treatment for IBD by regulating the balance of Treg/Th17 cells and the expression of IL-10 and IL-17A.

scholarly journals Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87956 ◽  
Author(s):  
Maria Serena Longhi ◽  
Alan Moss ◽  
Aiping Bai ◽  
Yan Wu ◽  
Huang Huang ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Th17 Cells ◽  
Suppressor Activity ◽  
Inflammatory Bowel

scholarly journals Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

Gut ◽  
2013 ◽  
Vol 63 (4) ◽  
pp. 567-577 ◽  
Author(s):  
Cornelia Tillack ◽  
Laura Maximiliane Ehmann ◽  
Matthias Friedrich ◽  
Rüdiger P Laubender ◽  
Pavol Papay ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Th17 Cells ◽  
Skin Lesions ◽  
Interferon Γ ◽  
Th1 Cells ◽  
Antibody Treatment ◽  
Inflammatory Bowel
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