Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas

2001 ◽  
Vol 93 (2) ◽  
pp. 232-235 ◽  
Author(s):  
Viola M.M. van Houten ◽  
Peter J.F. Snijders ◽  
Michiel W.M. van den Brekel ◽  
J. Alain Kummer ◽  
Chris J.L.M. Meijer ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Human Papillomaviruses ◽  
Biological Evidence

scholarly journals Causes and Consequences of HPV Integration in Head and Neck Squamous Cell Carcinomas: State of the Art

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4089
Author(s):  
Harini Balaji ◽  
Imke Demers ◽  
Nora Wuerdemann ◽  
Julia Schrijnder ◽  
Bernd Kremer ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Methylation Status ◽  
Squamous Cell Carcinomas ◽  
Human Papillomaviruses ◽  
Response To Therapy ◽  
Detection Techniques ◽  
Persistent Infections ◽  
Viral Dna Integration ◽  
The Impact

A constantly increasing incidence in high-risk Human Papillomaviruses (HPV)s driven head and neck squamous cell carcinomas (HNSCC)s, especially of oropharyngeal origin, is being observed. During persistent infections, viral DNA integration into the host genome may occur. Studies are examining if the physical status of the virus (episomal vs. integration) affects carcinogenesis and eventually has further-reaching consequences on disease progression and outcome. Here, we review the literature of the most recent five years focusing on the impact of HPV integration in HNSCCs, covering aspects of detection techniques used (from PCR up to NGS approaches), integration loci identified, and associations with genomic and clinical data. The consequences of HPV integration in the human genome, including the methylation status and deregulation of genes involved in cell signaling pathways, immune evasion, and response to therapy, are also summarized.

Prevalence of mucosotropic human papillomaviruses in squamous-cell carcinomas of the head and neck

1996 ◽  
Vol 66 (4) ◽  
pp. 464-469 ◽  
Author(s):  
Peter J. F. Snijders ◽  
Andrea G. M. Scholes ◽  
C. Anthony Hart ◽  
Andrew S. Jones ◽  
E. David Vaughan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Human Papillomaviruses

Smoking correlates with the presence of p53 mutations in squamous cell carcinomas of the head and neck (SCCHN)

1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Mutations

Identification of the Genomic Structure of Tumor Suppressor ING1 and Mutation Analysis in Head and Neck Squamous Cell Carcinomas

2005 ◽  
Vol 14 (2) ◽  
pp. 320-321
Author(s):  
Mehmet Gunduz ◽  
Esra Gunduz ◽  
Byung-Moo Min ◽  
Gene Lee ◽  
Ji-Jun Lim ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Head And Neck ◽  
Mutation Analysis ◽  
Squamous Cell ◽  
Genomic Structure ◽  
Squamous Cell Carcinomas

O53. Multicenter validation of a lymph node metastasis gene expression signature for head and neck squamous cell carcinomas

Oral Oncology ◽  
2011 ◽  
Vol 47 ◽  
pp. S46
Author(s):  
F.K.J. Leusink ◽  
P.J. Slootweg ◽  
M.W.M. van den Brekel ◽  
R.J. Baatenburg de Jong ◽  
F.C.P. Holstege ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Head And Neck ◽  
Squamous Cell ◽  
Gene Expression Signature ◽  
Squamous Cell Carcinomas ◽  
Expression Signature ◽  
Node Metastasis ◽  
Multicenter Validation

Long-Term Follow-up on an Intensified Treatment Regimen for Advanced Resectable Head and Neck Squamous Cell Carcinomas

2001 ◽  
Vol 19 (2) ◽  
pp. 127-136 ◽  
Author(s):  
John C. Grecula ◽  
David E. Schuller ◽  
Roy Smith ◽  
Chris A. Rhoades ◽  
Subir Nag ◽  
...  
Keyword(s):  
Head And Neck ◽  
Treatment Regimen ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Long Term Follow Up

Fever range whole body hyperthermia for re-irradiation of head and neck squamous cell carcinomas: Final results of a prospective study

Oral Oncology ◽  
2021 ◽  
Vol 116 ◽  
pp. 105240
Author(s):  
Sebastian Zschaeck ◽  
Julian Weingärtner ◽  
Pirus Ghadjar ◽  
Peter Wust ◽  
Felix Mehrhof ◽  
...  
Keyword(s):  
Prospective Study ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Whole Body ◽  
Whole Body Hyperthermia ◽  
A Prospective Study
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