High frequency of microsatellite instability in young patients with head-and-neck squamous-cell carcinoma: Lack of involvement of the mismatch repair geneshMLH1 ANDhMSH2

2001 ◽  
Vol 93 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Yimin Wang ◽  
Jonathan Irish ◽  
Christina MacMillan ◽  
Dale Brown ◽  
Yali Xuan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mismatch Repair ◽  
Squamous Cell ◽  
High Frequency ◽  
Young Patients ◽  
Neck Squamous Cell Carcinoma

scholarly journals Human papillomavirus status in young patients with head and neck squamous cell carcinoma

2011 ◽  
Vol 130 (8) ◽  
pp. 1806-1812 ◽  
Author(s):  
H.S. van Monsjou ◽  
M.L.F. van Velthuysen ◽  
M.W.M. van den Brekel ◽  
E.S. Jordanova ◽  
C.J.M. Melief ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Young Patients ◽  
Neck Squamous Cell Carcinoma

scholarly journals The clinical study of head and neck squamous cell carcinoma. Examination of the young patients and the aged patients.

1990 ◽  
Vol 36 (5) ◽  
pp. 1296-1307
Author(s):  
Mitsuhiro NAKAZAWA ◽  
Motohiro TSUJINO ◽  
Tomoji MORIYAMA ◽  
Tetsurou SUMI ◽  
Yoshihide MORI ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Study ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Young Patients ◽  
Neck Squamous Cell Carcinoma ◽  
Aged Patients

scholarly journals De-Escalating Strategies in HPV-Associated Head and Neck Squamous Cell Carcinoma

Viruses ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1787
Author(s):  
Panagiota Economopoulou ◽  
Ioannis Kotsantis ◽  
Amanda Psyrri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Young Patients ◽  
Treatment Strategies ◽  
Predictive Biomarker ◽  
Current Data ◽  
Neck Squamous Cell Carcinoma ◽  
Hpv Status

HPV-related head and neck squamous cell carcinoma (HNSCC) has emerged as a diverse clinical and biological disease entity, mainly in young patients with oropharyngeal tumors who are nonsmokers and nondrinkers. Indeed, during the past few years, the pendulum has shifted towards a new epidemiological reality, the “HPV pandemic”, where the majority of oropharyngeal squamous cell carcinomas (OPSCCs) are attributed to HPV. The oncogenic potential of the virus is associated to its capacity of integrating oncogenes E6 and E7 into the host cell, leading to the inactivation of several tumor suppressor genes, such as Rb. HPV status can affect prognosis in OPSCC, but its role as a predictive biomarker remains to be elucidated. Given the favorable prognosis associated with HPV-positive disease, the concept of de-escalation treatment strategies has been developed with the primary intent being the reduction of treatment-related long-term toxicities. In this review, we aim to depict current data regarding treatment de-escalation in HPV-associated OPSCC and discuss ongoing clinical trials.

Tetranucleotide Microsatellite Instability in Surgical Margins for Prediction of Local Recurrence of Head and Neck Squamous Cell Carcinoma

2004 ◽  
Vol 10 (12) ◽  
pp. 4022-4028 ◽  
Author(s):  
Stephane Temam ◽  
Odile Casiraghi ◽  
Jean-Baptiste Lahaye ◽  
Jacques Bosq ◽  
Xian Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Local Recurrence ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Surgical Margins ◽  
Neck Squamous Cell Carcinoma

scholarly journals The etiologic spectrum of head and neck squamous cell carcinoma in young patients

Oncotarget ◽  
2016 ◽  
Vol 7 (40) ◽  
pp. 66226-66238 ◽  
Author(s):  
Xin Liu ◽  
Xiao-lei Gao ◽  
Xin-hua Liang ◽  
Ya-ling Tang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Young Patients ◽  
Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma: Better to be young

2000 ◽  
Vol 122 (2) ◽  
pp. 253-258 ◽  
Author(s):  
Peter D. Lacy ◽  
Jay F. Piccirillo ◽  
Michael G. Merritt ◽  
Maria R. Zequeira
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Rate ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Young Patients ◽  
Neck Squamous Cell Carcinoma ◽  
Middle Aged ◽  
Old Patients ◽  
The Impact

Most head and neck squamous cell carcinoma patients are elderly, with few younger than 40 years. Controversy exists in the literature regarding outcomes for younger patients. The goal of this research project was to compare baseline features and outcomes for young patients (≤40 years), middle-aged patients (41–64 years), and old patients (≥65 years). To investigate the relationship between age and important presenting features and outcomes, 1160 recently diagnosed patients first treated at Washington University between 1980 and 1991 were identified from an existing database. Full 5-year survival information was available for 1030 patients (89%). Overall, the 5-year survival rate was 46% (478/1030); young patients (65%, 26/40) had a significantly better survival rate than middle-aged (52%, 292/566) or old patients (38%, 160/424) (χ2 = 24.5; P = 0.001). Survival was also related to smoking, comorbidity, primary site, TNM stage, and nodal disease. Age remained a significant factor even after we controlled for these other factors. Young patients developed fewer recurrent and new primary tumors. We conclude that young patients have a much better overall prognosis than older patients. The reasons for this difference are unclear, but it appears that the impact of age goes beyond an actuarial effect.

Analysis of 724 cases of primary head and neck squamous cell carcinoma (HNSCC) with a focus on young patients and p53 immunolocalization

Oral Oncology ◽  
2009 ◽  
Vol 45 (9) ◽  
pp. 777-782 ◽  
Author(s):  
A.M.B. De Paula ◽  
L.R. Souza ◽  
L.C. Farias ◽  
G.T.B. Corrêa ◽  
C.A.C. Fraga ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Young Patients ◽  
Neck Squamous Cell Carcinoma

High frequency of HPV16-associated head and neck squamous cell carcinoma in the Puerto Rican population

Head & Neck ◽  
2004 ◽  
Vol 26 (9) ◽  
pp. 778-784 ◽  
Author(s):  
Adriana Báez ◽  
José I. Almodóvar ◽  
Alan Cantor ◽  
Frederic Celestin ◽  
Luis Cruz-Cruz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Puerto Rican ◽  
Squamous Cell ◽  
High Frequency ◽  
Neck Squamous Cell Carcinoma

Microsatellite instability associated with durable complete response to PD-L1 inhibitor in head and neck squamous cell carcinoma

Oral Oncology ◽  
2018 ◽  
Vol 80 ◽  
pp. 104-107 ◽  
Author(s):  
Magalie P. Tardy ◽  
Ilaria Di Mauro ◽  
Nathalie Ebran ◽  
Sadal Refae ◽  
Alexandre Bozec ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Complete Response ◽  
Neck Squamous Cell Carcinoma ◽  
Durable Complete Response

Association between genetic polymorphisms in DNA mismatch repair-related genes with risk and prognosis of head and neck squamous cell carcinoma

2015 ◽  
Vol 137 (4) ◽  
pp. 810-818 ◽  
Author(s):  
Guilherme Augusto Silva Nogueira ◽  
Gustavo Jacob Lourenço ◽  
Camila Borges Martins Oliveira ◽  
Fernando Augusto Lima Marson ◽  
Leisa Lopes-Aguiar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Mismatch Repair ◽  
Genetic Polymorphisms ◽  
Squamous Cell ◽  
Dna Mismatch Repair ◽  
Neck Squamous Cell Carcinoma ◽  
Dna Mismatch
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