scholarly journals Second primary neoplasms in survivors of Wilms' tumour-A population-based cohort study from the British Childhood Cancer Survivor Study

2008 ◽  
Vol 122 (9) ◽  
pp. 2085-2093 ◽  
Author(s):  
Aliki J. Taylor ◽  
David L. Winter ◽  
Kathy Pritchard-Jones ◽  
Charles A. Stiller ◽  
Clare Frobisher ◽  
...  
Keyword(s):  
Cohort Study ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Population Based ◽  
Childhood Cancer Survivor ◽  
Second Primary ◽  
Wilms Tumour ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms ◽  
Childhood Cancer Survivor Study

scholarly journals Risk of Second Primary Thyroid Cancer after Radiotherapy for a Childhood Cancer in a Large Cohort Study: An Update from the Childhood Cancer Survivor Study

2010 ◽  
Vol 174 (6a) ◽  
pp. 741-752 ◽  
Author(s):  
Parveen Bhatti ◽  
Lene H. S. Veiga ◽  
Cécile M. Ronckers ◽  
Alice J. Sigurdson ◽  
Marilyn Stovall ◽  
...  
Keyword(s):  
Cohort Study ◽  
Thyroid Cancer ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Large Cohort ◽  
Childhood Cancer Survivor ◽  
Second Primary ◽  
Large Cohort Study ◽  
Childhood Cancer Survivor Study

scholarly journals Population-Based Risks of CNS Tumors in Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study

2010 ◽  
Vol 28 (36) ◽  
pp. 5287-5293 ◽  
Author(s):  
Aliki J. Taylor ◽  
Mark P. Little ◽  
David L. Winter ◽  
Elaine Sugden ◽  
David W. Ellison ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Cancer Survivor ◽  
Population Based ◽  
Childhood Cancer Survivor ◽  
Cns Tumors ◽  
Intrathecal Methotrexate ◽  
Second Primary ◽  
National Population ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer

Purpose CNS tumors are the most common second primary neoplasm (SPN) observed after childhood cancer in Britain, but the relationship of risk to doses of previous radiotherapy and chemotherapy is uncertain. Methods The British Childhood Cancer Survivor Study is a national, population-based, cohort study of 17,980 individuals surviving at least 5 years after diagnosis of childhood cancer. Linkage to national, population-based cancer registries identified 247 SPNs of the CNS. Cohort and nested case-control studies were undertaken. Results There were 137 meningiomas, 73 gliomas, and 37 other CNS neoplasms included in the analysis. The risk of meningioma increased strongly, linearly, and independently with each of dose of radiation to meningeal tissue and dose of intrathecal methotrexate. Those whose meningeal tissue received 0.01 to 9.99, 10.00 to 19.99, 20.00 to 29.99, 30.00 to 39.99 and ≥ 40 Gy had risks that were two-fold, eight-fold, 52-fold, 568-fold, and 479-fold, respectively, the risks experienced by those whose meningeal tissue was unexposed. The risk of meningioma among individuals receiving 1 to 39,40 to 69, and at least 70 mg/m2 of intrathecal methotrexate was 15-fold, 11-fold, and 36-fold, respectively, the risk experienced by those unexposed. The standardized incidence ratio for gliomas was 10.8 (95% CI, 8.5 to 13.6). The risk of glioma/primitive neuroectodermal tumors increased linearly with dose of radiation, and those who had CNS tissue exposed to at least 40 Gy experienced a risk four-fold that experienced by those who had CNS tissue unexposed. Conclusion The largest-ever study, to our knowledge, of CNS tumors in survivors of childhood cancer indicates that the risk of meningioma increases rapidly with increased dose of radiation to meningeal tissue and with increased dose of intrathecal methotrexate.

scholarly journals Predicting acute ovarian failure in female survivors of childhood cancer: a cohort study in the Childhood Cancer Survivor Study (CCSS) and the St Jude Lifetime Cohort (SJLIFE)

2020 ◽  
Vol 21 (3) ◽  
pp. 436-445 ◽  
Author(s):  
Rebecca A Clark ◽  
Sogol Mostoufi-Moab ◽  
Yutaka Yasui ◽  
Ngoc Khanh Vu ◽  
Charles A Sklar ◽  
...  
Keyword(s):  
Cohort Study ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Ovarian Failure ◽  
Childhood Cancer Survivor ◽  
Female Survivors ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer

scholarly journals Cancer predisposition syndromes as risk factor for early second primary neoplasms after childhood cancer - a national cohort study

2020 ◽  
Author(s):  
Nicolas Waespe ◽  
Fabien Naomi Belle ◽  
Shelagh Redmond ◽  
Christina Schindera ◽  
Ben Daniel Spycher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Childhood Cancer ◽  
Cancer Patients ◽  
Cumulative Incidence ◽  
Cancer Predisposition ◽  
Second Primary ◽  
Hematopoietic Stem ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms

Background: Childhood cancer patients are at increased risk of second primary neoplasms (SPNs). We assessed incidence and risk factors for early SPNs with a focus on cancer predisposition syndromes (CPSs). Patients and methods: This cohort study used data from the Swiss Childhood Cancer Registry. We included patients with first primary neoplasms (FPN) until age 21 years from 1986 to 2015 and identified SPNs occurring before age 21. We calculated standardized incidence ratios (SIR) and absolute excess risks (AER) using Swiss population cancer incidence data and cumulative incidence of SPNs. We calculated hazard ratios (HR) of risk factors for SPNs using Fine and Gray competing risk regression. Results: Among 8,074 childhood cancer patients, 304 (4%) were diagnosed with a CPS and 94 (1%) developed early SPNs. The incidence of SPNs was more than 10-fold increased in childhood cancer patients compared to neoplasms in the general population (SIR 10.6, 95%-confidence interval [CI] 8.7-13.1) and the AER was 179/100,000 person-years (CI 139-219). Cumulative incidence of SPNs 20 years after FPN diagnosis was 23% in patients with CPSs and 3% in those without. Risk factors for SPNs were CPSs (HR 7.8, CI 4.8-12.7), chemotherapy (HR 2.2, CI 1.1-4.6), radiotherapy (HR 1.9, CI 1.2-2.9), hematopoietic stem cell transplantation (HR 1.8, CI 1-3.3), and older age (15-20 years) at FPN diagnosis (HR 1.9, CI 1.1-3.2). Conclusion: CPSs are associated with a high risk of SPNs before age 21 years. Identification of CPSs is important for appropriate cancer surveillance and targeted screening.

scholarly journals Cancer predisposition syndromes as a risk factor for early second primary neoplasms after childhood cancer – A national cohort study

2021 ◽  
Vol 145 ◽  
pp. 71-80
Author(s):  
Nicolas Waespe ◽  
Fabiën N. Belle ◽  
Shelagh Redmond ◽  
Christina Schindera ◽  
Ben D. Spycher ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Childhood Cancer ◽  
Cancer Predisposition ◽  
Second Primary ◽  
Second Primary Neoplasms ◽  
National Cohort ◽  
Primary Neoplasms

scholarly journals New Primary Neoplasms of the Central Nervous System in Survivors of Childhood Cancer: a Report From the Childhood Cancer Survivor Study

2006 ◽  
Vol 98 (21) ◽  
pp. 1528-1537 ◽  
Author(s):  
Joseph P. Neglia ◽  
Leslie L. Robison ◽  
Marilyn Stovall ◽  
Yan Liu ◽  
Roger J. Packer ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Childhood Cancer Survivor ◽  
The Central Nervous System ◽  
Primary Neoplasms ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer

scholarly journals No evidence of response bias in a population-based childhood cancer survivor questionnaire survey — Results from the Swiss Childhood Cancer Survivor Study

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176442 ◽  
Author(s):  
Corina S. Rueegg ◽  
Micòl E. Gianinazzi ◽  
Gisela Michel ◽  
Marcel Zwahlen ◽  
Nicolas X. von der Weid ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Response Bias ◽  
Cancer Survivor ◽  
Questionnaire Survey ◽  
Population Based ◽  
Childhood Cancer Survivor ◽  
Survey Results ◽  
Childhood Cancer Survivor Study
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