scholarly journals Cancer predisposition syndromes as a risk factor for early second primary neoplasms after childhood cancer – A national cohort study

2021 ◽  
Vol 145 ◽  
pp. 71-80
Author(s):  
Nicolas Waespe ◽  
Fabiën N. Belle ◽  
Shelagh Redmond ◽  
Christina Schindera ◽  
Ben D. Spycher ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Childhood Cancer ◽  
Cancer Predisposition ◽  
Second Primary ◽  
Second Primary Neoplasms ◽  
National Cohort ◽  
Primary Neoplasms

scholarly journals Cancer predisposition syndromes as risk factor for early second primary neoplasms after childhood cancer - a national cohort study

2020 ◽  
Author(s):  
Nicolas Waespe ◽  
Fabien Naomi Belle ◽  
Shelagh Redmond ◽  
Christina Schindera ◽  
Ben Daniel Spycher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Childhood Cancer ◽  
Cancer Patients ◽  
Cumulative Incidence ◽  
Cancer Predisposition ◽  
Second Primary ◽  
Hematopoietic Stem ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms

Background: Childhood cancer patients are at increased risk of second primary neoplasms (SPNs). We assessed incidence and risk factors for early SPNs with a focus on cancer predisposition syndromes (CPSs). Patients and methods: This cohort study used data from the Swiss Childhood Cancer Registry. We included patients with first primary neoplasms (FPN) until age 21 years from 1986 to 2015 and identified SPNs occurring before age 21. We calculated standardized incidence ratios (SIR) and absolute excess risks (AER) using Swiss population cancer incidence data and cumulative incidence of SPNs. We calculated hazard ratios (HR) of risk factors for SPNs using Fine and Gray competing risk regression. Results: Among 8,074 childhood cancer patients, 304 (4%) were diagnosed with a CPS and 94 (1%) developed early SPNs. The incidence of SPNs was more than 10-fold increased in childhood cancer patients compared to neoplasms in the general population (SIR 10.6, 95%-confidence interval [CI] 8.7-13.1) and the AER was 179/100,000 person-years (CI 139-219). Cumulative incidence of SPNs 20 years after FPN diagnosis was 23% in patients with CPSs and 3% in those without. Risk factors for SPNs were CPSs (HR 7.8, CI 4.8-12.7), chemotherapy (HR 2.2, CI 1.1-4.6), radiotherapy (HR 1.9, CI 1.2-2.9), hematopoietic stem cell transplantation (HR 1.8, CI 1-3.3), and older age (15-20 years) at FPN diagnosis (HR 1.9, CI 1.1-3.2). Conclusion: CPSs are associated with a high risk of SPNs before age 21 years. Identification of CPSs is important for appropriate cancer surveillance and targeted screening.

scholarly journals Second primary neoplasms in survivors of Wilms' tumour-A population-based cohort study from the British Childhood Cancer Survivor Study

2008 ◽  
Vol 122 (9) ◽  
pp. 2085-2093 ◽  
Author(s):  
Aliki J. Taylor ◽  
David L. Winter ◽  
Kathy Pritchard-Jones ◽  
Charles A. Stiller ◽  
Clare Frobisher ◽  
...  
Keyword(s):  
Cohort Study ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Population Based ◽  
Childhood Cancer Survivor ◽  
Second Primary ◽  
Wilms Tumour ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms ◽  
Childhood Cancer Survivor Study

Primary Malignant Neoplasms Associated with Chronic Lymphocytic Leukemia

1980 ◽  
Vol 66 (4) ◽  
pp. 431-438 ◽  
Author(s):  
Armando Santoro ◽  
Franco Rilke ◽  
Franca Franchi ◽  
Silvio Monfardini
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Alkylating Agents ◽  
Malignant Lesion ◽  
Lymphocytic Leukemia ◽  
Second Primary ◽  
Malignant Neoplasms ◽  
Primary Malignancy ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms ◽  
Cellular And Humoral Immunity

Over the past 2 decades there has been an almost exponential increase in the frequency with which cases of leukemia associated with another primary malignant lesion have been reported. In this study we reported the occurrence of a second primary neoplasm in 82 consecutive cases of chronic lymphocytic leukemia (CLL) admitted to the Istituto Nazionale Tumori of Milan from September 1962 to December 1978. In 16 of these (19.5%), an associated neoplasm was diagnosed subsequently (8 cases) or concurrently (8 cases) to CLL. Head and neck carcinomas and breast cancer had the highest incidence (5 and 3 cases, respectively). The results of this study further support the hypothesis that patients with CLL are prone to develop subsequent cancer. The defective cellular and humoral immunity in CLL may have an etiological role in the development of an additional primary malignancy. Although alkylating agents are known carcinogens in experimental animals and man, our results support the lack of a correlation between treatment with alkylating agents and incidence of second primary neoplasms, as demonstrated by Greene et al. (10).

Second Primary Neoplasms Following a Diagnosis of Breast Cancer

2016 ◽  
pp. 213-234
Author(s):  
Felicity Paterson ◽  
Susannah Stanway ◽  
Lone Gothard ◽  
Navita Somaiah
Keyword(s):  
Breast Cancer ◽  
Second Primary ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms

CT and MRI Features of Recurrent Tumors and Second Primary Neoplasms in Pediatric Patients with Retinoblastoma

2003 ◽  
Vol 181 (3) ◽  
pp. 879-884 ◽  
Author(s):  
Ukihide Tateishi ◽  
Tadashi Hasegawa ◽  
Kunihisa Miyakawa ◽  
Minako Sumi ◽  
Noriyuki Moriyama
Keyword(s):  
Pediatric Patients ◽  
Second Primary ◽  
Second Primary Neoplasms ◽  
Recurrent Tumors ◽  
Mri Features ◽  
Primary Neoplasms ◽  
Ct And Mri

Smoke and alcohol consumption as a risk factors in the development of second primary neoplasms (SPN) in head & neck cancer (HNC) patients. A case-control study

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5582-5582
Author(s):  
T. Macarulla ◽  
M. Prado Venegas ◽  
X. León ◽  
A. López Pousa ◽  
M. Quer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Consumption ◽  
Case Control Study ◽  
Case Control ◽  
Second Primary ◽  
Head Neck Cancer ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms ◽  
Head Neck ◽  
Control Study

Second primary neoplasms after 19281 endocrine gland tumours

2001 ◽  
Vol 37 (15) ◽  
pp. 1886-1894 ◽  
Author(s):  
K Hemminki ◽  
Y Jiang
Keyword(s):  
Second Primary ◽  
Endocrine Gland ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms

scholarly journals Short-term and long-term effects of childhood cancer on income from employment and employment status: A national cohort study in Sweden

Cancer ◽  
2016 ◽  
Vol 123 (7) ◽  
pp. 1238-1248 ◽  
Author(s):  
Annika Lindahl Norberg ◽  
Scott M. Montgomery ◽  
Matteo Bottai ◽  
Mats Heyman ◽  
Emma I. Hovén
Keyword(s):  
Cohort Study ◽  
Childhood Cancer ◽  
Employment Status ◽  
Long Term Effects ◽  
Short Term ◽  
National Cohort

scholarly journals Second Primary Neoplasms in Patients With Laryngeal Carcinoma

2000 ◽  
Vol 110 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Angelos C. Nikolaou ◽  
Constantinos D. Markou ◽  
Dimitrios G. Petridis ◽  
Ioannis C. Daniilidis
Keyword(s):  
Laryngeal Carcinoma ◽  
Second Primary ◽  
Second Primary Neoplasms ◽  
Primary Neoplasms
Sign in / Sign up

Export Citation Format

Share Document