Expression and function of the insulin-like growth factor I system in human non-small-cell lung cancer and normal lung cell lines

1994 ◽  
Vol 56 (6) ◽  
pp. 858-866 ◽  
Author(s):  
Roberto E. Favoni ◽  
Alessandra De Cupis ◽  
Federica Ravera ◽  
Claudia Cantoni ◽  
Paolo Pirani ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Normal Lung ◽  
Small Cell Lung ◽  
Factor I ◽  
And Function

The Key microRNAs Regulated the Development of Non-small Cell Lung Cancer by Targeting TGF-β-induced epithelial–mesenchymal Transition

2019 ◽  
Vol 22 (4) ◽  
pp. 238-244 ◽  
Author(s):  
Gang Chen ◽  
Bo Ye
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Nsclc Cell ◽  
Normal Lung ◽  
Migration And Invasion ◽  
Small Cell Lung ◽  
Mesenchymal Transition

Purpose: Epithelial-to-Mesenchymal Transition (EMT) was reported to play a key role in the development of Non-Small Cell Lung Cancer (NSCLC). The process of EMT is regulated by the changes of miRNAs expression. However, it is still unknown which miRNA changed the most in the process of canceration and whether these changes played a role in tumor development. Methods: A total of 36 SCLC patients treated in our hospital between 11th, 2015 and 10th, 2017 were enrolled. The samples of cancer tissues and paracancer tissues of patients were collected and analyzed. Then, the miRNAs in normal lung cells and NSCLC cells were also analyzed. In the presence of TGF-β, we transfected the miRNA mimics or inhibitor into NSCLC cells to investigate the role of the significantly altered miRNAs in cell migration and invasion and in the process of EMT. Results: MiR-330-3p was significantly up-regulated in NSCLC cell lines and tissues and miRNA- 205 was significantly down-regulated in NSCLC cell lines and NSCLC tissues. Transfected miRNA-205 mimics or miRMA-330-3p inhibitor inhibited the migration and invasion of NCIH1975 cell and restrained TGF-β-induced EMT in NSCLC cells. Conclusion: miRNA-330-3p and miRNA-205 changed the most in the process of canceration in NSCLC. Furthermore, miR-330-3p promoted cell invasion and metastasis in NSCLC probably by promoting EMT and miR-205 could restrain NSCLC likely by suppressing EMT.

Production of immunoreactive insulin-like growth factor I and response to exogenous IGF-I in small cell lung cancer cell lines

1988 ◽  
Vol 176 (2) ◽  
pp. 336-343 ◽  
Author(s):  
Gabriele Jaques ◽  
Martin Rotsch ◽  
Cordelia Wegmann ◽  
Ursula Worsch ◽  
Michael Maasberg ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Small Cell ◽  
Immunoreactive Insulin ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Factor I ◽  
Igf I

scholarly journals Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

1988 ◽  
Vol 82 (1) ◽  
pp. 354-359 ◽  
Author(s):  
Y Nakanishi ◽  
J L Mulshine ◽  
P G Kasprzyk ◽  
R B Natale ◽  
R Maneckjee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Factor I

scholarly journals Somatomedin-C/insulin-like growth factor-I is a mitogen for human small cell lung cancer

1988 ◽  
Vol 57 (1) ◽  
pp. 91-93 ◽  
Author(s):  
VM Macauly ◽  
JD Teale ◽  
MJ Everard ◽  
GP Joshi ◽  
IE Smith ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Insulin Like Growth Factor ◽  
Small Cell Lung ◽  
Somatomedin C ◽  
Factor I ◽  
Growth Factor I

Serum insulin-like growth factor-I levels in patients with small cell lung cancer

1988 ◽  
Vol 24 (7) ◽  
pp. 1241-1242 ◽  
Author(s):  
Valentine M. Macaulay ◽  
J. Derrick Teale ◽  
Michele J. Everard ◽  
Gopu P. Joshi ◽  
John L. Millar ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Serum Insulin ◽  
Small Cell ◽  
Insulin Like Growth Factor ◽  
Small Cell Lung ◽  
Factor I ◽  
Growth Factor I

Production of insulin-like growth factor binding proteins by small-cell lung cancer cell lines

1989 ◽  
Vol 184 (2) ◽  
pp. 396-406 ◽  
Author(s):  
Gabriele Jaques ◽  
Paul Kiefer ◽  
Martin Rotsch ◽  
Cordula Hennig ◽  
Rüdiger Göke ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Binding Proteins ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung
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