Quercetin enhances transforming growth factor β1, secretion by human ovarian cancer cells

1994 ◽  
Vol 57 (2) ◽  
pp. 211-215 ◽  
Author(s):  
Giovanni Scambia ◽  
Pierluigi Benedetti Panici ◽  
F. O. Ranelletti ◽  
G. Ferrandina ◽  
R. de Vincenzo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer

scholarly journals Transforming Growth Factor-β1-dependent Urokinase Up-regulation and Promotion of Invasion Are Involved in Src-MAPK-dependent Signaling in Human Ovarian Cancer Cells

2003 ◽  
Vol 279 (10) ◽  
pp. 8567-8576 ◽  
Author(s):  
Yoshiko Tanaka ◽  
Hiroshi Kobayashi ◽  
Mika Suzuki ◽  
Naohiro Kanayama ◽  
Toshihiko Terao
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer

miR-30d Blocked Transforming Growth Factor β1–Induced Epithelial-Mesenchymal Transition by Targeting Snail in Ovarian Cancer Cells

2015 ◽  
Vol 25 (9) ◽  
pp. 1574-1581 ◽  
Author(s):  
Zhongxue Ye ◽  
Le Zhao ◽  
Jie Li ◽  
Wei Chen ◽  
Xu Li
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Epithelial Mesenchymal Transition ◽  
Transforming Growth Factor Β1 ◽  
Ovarian Cancer Cells ◽  
Mesenchymal Transition ◽  
Polymerase Chain ◽  
Tgf Β1

ObjectiveMicroRNAs (miRs) are essential regulators of gene expression by suppressing translation or causing degradation of target mRNA. Growing evidence sheds light on the crucial roles of miR dysregulation in cancer development and progression. In this study, we focused on the role of miR-30d in transforming growth factor β1 (TGF-β1)–initiated epithelial-mesenchymal transition (EMT) in ovarian cancer cells.MethodsTransforming growth factor β1 (10 ng/mL) was used to initiate EMT in SKOV3 and 3AO cells. The expression of miR-30 family members was determined by quantitative real-time polymerase chain reaction. Messenger RNA and protein levels of E-cadherin, N-cadherin, vimentin, and Snail were detected by quantitative real-time polymerase chain reaction and Western blot, respectively. Cell migration and invasion capacities were evaluated by Transwell chamber assay. Luciferase activity assay was performed to verify the direct inhibition of Snail by miR-30d.ResultsMiR-30b, MiR-30c, and MiR-30d were down-regulated during TGF-β1–induced EMT in SKOV3 and 3AO ovarian cancer cells. Restoration of miR-30d by miR-30d mimic reversed TGF-β1–induced EMT phenotypes including the morphological changes, expression pattern of molecular markers (E-cadherin, N-cadherin), and migratory and invasive capabilities in ovarian cancer cells. Furthermore, Snail was identified as the direct target of miR-30d.ConclusionsOur results revealed that miR-30d functioned as a suppressor of ovarian cancer progression by decreasing Snail expression and thus blocking TGF-β1–induced EMT process, suggesting the potentiality of miR-30d analogs to be used as therapeutics for ovarian cancer.

scholarly journals Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites

Cancer ◽  
1994 ◽  
Vol 74 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Jean Hurteau ◽  
Gustavo C. Rodriguez ◽  
Regina S. Whitaker ◽  
Shafquat Shah ◽  
Gordon Mills ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Growth Factor Beta

Transforming growth factor-?1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells

2004 ◽  
Vol 93 (3) ◽  
pp. 437-453 ◽  
Author(s):  
Kiyoshi Wakahara ◽  
Hiroshi Kobayashi ◽  
Tatsuo Yagyu ◽  
Hidenori Matsuzaki ◽  
Toshiharu Kondo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Pai 1

scholarly journals Stimulation of c-myc protooncogene expression by transforming growth factor a in human ovarian cancer cells

1997 ◽  
Vol 29 (4) ◽  
pp. 203-208
Author(s):  
Jeong-Youn Choi ◽  
Young-Sook Hong ◽  
Hae-Young Park
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Stimulation Of

Inactivation of transforming growth factor-β-activated kinase 1 promotes taxol efficacy in ovarian cancer cells

2016 ◽  
Vol 84 ◽  
pp. 917-924 ◽  
Author(s):  
Li Bo ◽  
Huchuan Cui ◽  
Zhengxian Fang ◽  
Tao Qun ◽  
Caoyun Xia
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Ovarian Cancer Cells

scholarly journals Human Granulocyte-Macrophage Colony-stimulating Factor Is a Growth Factor Active on Human Ovarian Cancer Cells

1991 ◽  
Vol 82 (11) ◽  
pp. 1196-1198 ◽  
Author(s):  
Guido Cimoli ◽  
Patrizia Russo ◽  
Giovanna Billi ◽  
Gabriella Lucia Mariani ◽  
Elisabetta Rovini ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor
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