scholarly journals Hyperglycaemia and aberrated insulin signalling stimulate tumour progression via induction of the extracellular matrix component hyaluronan

2017 ◽  
Vol 141 (4) ◽  
pp. 791-804 ◽  
Author(s):  
Sören Twarock ◽  
Christina Reichert ◽  
Ulrike Peters ◽  
Daniel J. Gorski ◽  
Katharina Röck ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Insulin Signalling ◽  
Tumour Progression ◽  
Extracellular Matrix Component ◽  
Matrix Component

The impact of age on cardiac function and extracellular matrix component expression in adverse post-infarction remodeling in mice

2019 ◽  
Vol 119 ◽  
pp. 193-202 ◽  
Author(s):  
Felix Nagel ◽  
David Santer ◽  
Stefan Stojkovic ◽  
Christoph Kaun ◽  
Anne-Kristin Schaefer ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cardiac Function ◽  
Extracellular Matrix Component ◽  
Matrix Component ◽  
The Impact

Extracellular Matrix Component Shelled Nanoparticles as Dual Enzyme-Responsive Drug Delivery Vehicles for Cancer Therapy

2018 ◽  
Vol 4 (7) ◽  
pp. 2404-2411 ◽  
Author(s):  
Juan Zhou ◽  
Mingyu Wang ◽  
Huiyan Ying ◽  
Dandan Su ◽  
Huijie Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Extracellular Matrix ◽  
Cancer Therapy ◽  
Extracellular Matrix Component ◽  
Matrix Component ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development

2007 ◽  
Vol 310 (2) ◽  
pp. 291-303 ◽  
Author(s):  
Elaine E. Wirrig ◽  
Brian S. Snarr ◽  
Mastan R. Chintalapudi ◽  
Jessica L. O'Neal ◽  
Aimee L. Phelps ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Heart Development ◽  
Extracellular Matrix Component ◽  
Matrix Component ◽  
Link Protein

Isolation and characterization of monkey interphotoreceptor retinoid-binding protein, a unique extracellular matrix component of the retina

Biochemistry ◽  
1985 ◽  
Vol 24 (3) ◽  
pp. 787-793 ◽  
Author(s):  
Thomas M. Redmond ◽  
Barbara Wiggert ◽  
Frank A. Robey ◽  
Nguyen Nga Yen ◽  
Marc S. Lewis ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Binding Protein ◽  
Protein A ◽  
Extracellular Matrix Component ◽  
Matrix Component ◽  
Interphotoreceptor Retinoid Binding Protein ◽  
Isolation And Characterization

scholarly journals Transglutaminase 2 strongly binds to an extracellular matrix component other than fibronectin via its second C‐terminal beta‐barrel domain

FEBS Journal ◽  
2016 ◽  
Vol 283 (21) ◽  
pp. 3994-4010 ◽  
Author(s):  
Jorunn Stamnaes ◽  
Inês Cardoso ◽  
Rasmus Iversen ◽  
Ludvig M. Sollid
Keyword(s):  
Extracellular Matrix ◽  
Transglutaminase 2 ◽  
Extracellular Matrix Component ◽  
Matrix Component ◽  
Beta Barrel

scholarly journals Modulation of canonical Wnt signaling by the extracellular matrix component biglycan

2011 ◽  
Vol 108 (41) ◽  
pp. 17022-17027 ◽  
Author(s):  
A. D. Berendsen ◽  
L. W. Fisher ◽  
T. M. Kilts ◽  
R. T. Owens ◽  
P. G. Robey ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wnt Signaling ◽  
Extracellular Matrix Component ◽  
Canonical Wnt Signaling ◽  
Matrix Component ◽  
Canonical Wnt

scholarly journals Evidence of Swim secretion and association with extracellular matrix in the Drosophila embryo

2021 ◽  
Author(s):  
Valeria Kaltezioti ◽  
Katerina M. Vakaloglou ◽  
Aristidis S. Charonis ◽  
Christos G. Zervas
Keyword(s):  
Extracellular Matrix ◽  
Expression System ◽  
Ectopic Expression ◽  
Basement Membranes ◽  
Confocal Imaging ◽  
Drosophila Embryo ◽  
Dependent Manner ◽  
Extracellular Matrix Component ◽  
Matrix Component

Secreted wingless-interacting protein (Swim) is the Drosophila ortholog gene of the mammalian Tubulointerstitial Nephritis Antigen Like 1 (TINAGL1), known also as lipocalin-7 (LCN7), or adrenocortical zonation factor 1 (AZ-1). Swim and TINAGL1 proteins share a significant homology, including the somatomedin B and the predictive inactive C1 cysteine peptidase domains. In mammals, both TINAGL1 and its closely related homolog TINAG have been identified in basement membranes, where they may function as modulators of integrin-mediated adhesion. In Drosophila, Swim was initially identified in the eggshell matrix and subsequently was detected in the culture medium of S2 cells. Further biochemical analysis indicated that Swim binds to wingless (wg) in a lipid-dependent manner. This observation together with RNAiknockdown studies suggested that Swim is an essential cofactor of wg-signalling. However, recent elegant genetic studies ruled out the possibility that Swim is required alone to facilitate wgsignalling in Drosophila, because flies without Swim are viable and fertile. Here, we use the UAS/Gal4 expression system together with confocal imaging to analyze the in vivo localization of a chimeric Swim-GFP in the developing Drosophila embryo. Our data fully support the notion that Swim is an extracellular matrix component that upon ectopic expression is secreted and preferentially associates with the basement membranes of various organs and with the specialized tendon matrix at the muscle attachment sites (MAS). Interestingly, the accumulation of Swim at the MAS does not require integrins. In conclusion, Swim is an extracellular matrix component, and it is possible that Swim exhibits overlapping functions in concert with other undefined components.

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