scholarly journals An effective dendritic cell‐based vaccine containing glioma stem‐like cell lysate and CpG adjuvant for an orthotopic mouse model of glioma

2019 ◽  
Vol 144 (11) ◽  
pp. 2867-2879 ◽  
Author(s):  
Shan Zhu ◽  
Xinping Lv ◽  
Xuhao Zhang ◽  
Tete Li ◽  
Guoxia Zang ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Mouse Model ◽  
Orthotopic Mouse Model ◽  
Cell Lysate ◽  
Dendritic Cell Based Vaccine

scholarly journals Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease

2015 ◽  
Vol 11 (4) ◽  
pp. 922-930 ◽  
Author(s):  
Kenneth E Ugen ◽  
Xiaoyang Lin ◽  
Ge Bai ◽  
Zhanhua Liang ◽  
Jianfeng Cai ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Mouse Model ◽  
Parkinson Disease ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Dendritic Cell Based Vaccine

Combination therapy with dendritic cell-based vaccine and chemotherapy is active against acute myeloid leukemia in a mouse model

Cytotherapy ◽  
2013 ◽  
Vol 15 (4) ◽  
pp. S35
Author(s):  
W. Ng ◽  
M. Abdullah ◽  
P. Chong ◽  
C. Leong ◽  
S. Fadilah ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Dendritic Cell ◽  
Combination Therapy ◽  
Mouse Model ◽  
Myeloid Leukemia ◽  
Dendritic Cell Based Vaccine ◽  
Acute Myeloid

Transfection with CD40L induces tumour suppression by dendritic cell activation in an orthotopic mouse model of pancreatic adenocarcinoma

Gut ◽  
2008 ◽  
Vol 57 (3) ◽  
pp. 344-351 ◽  
Author(s):  
S Serba ◽  
J Schmidt ◽  
N Wentzensen ◽  
E Ryschich ◽  
A Marten
Keyword(s):  
Dendritic Cell ◽  
Mouse Model ◽  
Pancreatic Adenocarcinoma ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
Orthotopic Mouse Model ◽  
Tumour Suppression

scholarly journals PATH-67. RECOMBINANT INTERLEUKIN-7 ENHANCES THE ANTI-TUMOR IMMUNITY OF A DENDRITIC CELL VACCINE IN A MURINE MALIGNANT GLIOMA

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi158-vi158
Author(s):  
Sol Hooy Oh ◽  
Stephen Ahn ◽  
Jae Sung Park ◽  
Yong Kil Hong ◽  
Sin-Soo Jeon
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Mouse Model ◽  
Malignant Glioma ◽  
Tumor Immunity ◽  
Dendritic Cell Vaccine ◽  
Cell Vaccine ◽  
Orthotopic Mouse Model ◽  
Interleukin 7 ◽  
Polycytidylic Acid

Abstract BACKGROUND Dendritic cell (DC)-based vaccines have been suggested as one of the promising immunotherapies for treating various cancers, including glioblastoma. We already developed a novel vaccination protocol with peptide-loaded DCs followed by a mixture of synthetic peptides, polyinosine- polycytidylic acid (poly-IC) and anti-CD40 antibodies (Trivax) in a melanoma mouse model. However, in a glioma mouse model, therapeutic efficacy is not as much as enough maybe due to relatively low antigenicity and blood brain barrier. MATERIAL AND METHODS IL-7, which is one of the most important cytokines to expand and develop T cells with anti-tumor immunity, was co-administrated intravenously with Trivax in an orthotopic murine malignant glioma. RESULTS Co-administration of the Trivax and recombinant IL-7 (Trivax7) increased the number of survivin specific T cells measured using ELISPOT assay and the population of central memory T cells, comparing with administration of Trivax. The tumor size of orthotopic mouse model in Trivax 7 group was smaller than those of Trivax only group. Finally, overall survival in Trivax 7 was longer than those of Trivax only. In addition, there was a prolonged survival of antigen-specific T cells in Trivax7 group than Trivax only group. CONCLUSION In summary, our novel combinational immunotherapy may overcome the limitations of current cell-based cancer vaccines and could be applicable for the treatment of glioblastoma patients.

The Cyclooxygenase-2 Inhibitor Celecoxib Attenuates Hepatocellular Carcinoma Growth and c-Met Expression in an Orthotopic Mouse Model

2011 ◽  
Vol 19 (3) ◽  
pp. 131-139 ◽  
Author(s):  
Jibin Yin ◽  
Bingrong Liu ◽  
Baoxin Li ◽  
Zhaojun Liu ◽  
Xinyu Xie ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Cyclooxygenase 2 ◽  
Orthotopic Mouse Model

scholarly journals IT-07 * COMPARATIVE EVALUATION OF pDCs AND mDCs FOR DENDRITIC CELL BASED VACCINE STRATEGY FOR MALIGNANT GLIOMA

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v111-v111
Author(s):  
M. Dey ◽  
A. Chang ◽  
D. Wainwright ◽  
A. Ahmed ◽  
Y. Han ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Malignant Glioma ◽  
Comparative Evaluation ◽  
Vaccine Strategy ◽  
Dendritic Cell Based Vaccine

Hope and Challenges for Dendritic Cell–Based Vaccine Therapy for Glioblastoma

2012 ◽  
Vol 77 (5-6) ◽  
pp. 633-635 ◽  
Author(s):  
Ichiro Nakano ◽  
E. Antonio Chiocca
Keyword(s):  
Dendritic Cell ◽  
Vaccine Therapy ◽  
Dendritic Cell Based Vaccine

scholarly journals Characterization of Lung Cancer by Amide Proton Transfer (APT) Imaging: An In-Vivo Study in an Orthotopic Mouse Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77019 ◽  
Author(s):  
Osamu Togao ◽  
Chase W. Kessinger ◽  
Gang Huang ◽  
Todd C. Soesbe ◽  
Koji Sagiyama ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mouse Model ◽  
Proton Transfer ◽  
In Vivo Study ◽  
Amide Proton ◽  
Orthotopic Mouse Model ◽  
Amide Proton Transfer ◽  
Apt Imaging
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