scholarly journals Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure

2021 ◽  
Author(s):  
Sandra KaranoviĆ ◽  
Maude Ardin ◽  
Zuojian Tang ◽  
Karla TomiĆ ◽  
Stephanie Villar ◽  
...  
Keyword(s):  
Aristolochic Acid ◽  
Acid Exposure ◽  
Urinary Biomarkers ◽  
Upper Tract ◽  
Urothelial Carcinomas ◽  
Molecular Profiles

scholarly journals Impact of aristolochic acid exposure on oncologic outcomes of upper tract urothelial carcinoma after radical nephroureterectomy

2017 ◽  
Vol Volume 10 ◽  
pp. 5775-5782 ◽  
Author(s):  
Wenlong Zhong ◽  
Lei Zhang ◽  
Jiajian Ma ◽  
Shan Shao ◽  
Rongcheng Lin ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Aristolochic Acid ◽  
Acid Exposure ◽  
Upper Tract Urothelial Carcinoma ◽  
Oncologic Outcomes ◽  
Radical Nephroureterectomy ◽  
Upper Tract

scholarly journals TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR

Oncotarget ◽  
2014 ◽  
Vol 5 (23) ◽  
pp. 12428-12439 ◽  
Author(s):  
Kun Wang ◽  
Tiantian Liu ◽  
Nan Ge ◽  
Li Liu ◽  
Xiaotian Yuan ◽  
...  
Keyword(s):  
Distant Metastases ◽  
Urinary Biomarkers ◽  
Upper Tract ◽  
Urothelial Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

scholarly journals Comprehensive integrative profiling of upper tract urothelial carcinomas

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xiaoping Su ◽  
Xiaofan Lu ◽  
Sehrish Khan Bazai ◽  
Eva Compérat ◽  
Roger Mouawad ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Somatic Mutations ◽  
Suppressor Gene ◽  
Epigenetic Alterations ◽  
Upper Tract ◽  
Urothelial Carcinomas ◽  
Immune Alterations ◽  
Invasive Status ◽  
Muscle Invasive ◽  
First Time

Abstract Background Crosstalk between genetic, epigenetic, and immune alterations in upper tract urothelial carcinomas and their role in shaping muscle invasiveness and patient outcome are poorly understood. Results We perform an integrative genome- and methylome-wide profiling of diverse non-muscle-invasive and muscle-invasive upper tract urothelial carcinomas. In addition to mutations of FGFR3 and KDM6A, we identify ZFP36L1 as a novel, significantly mutated tumor suppressor gene. Overall, mutations of ZFP36 family genes (ZFP36, ZFP36L1, and ZFP36L2) are identified in 26.7% of cases, which display a high mutational load. Unsupervised DNA methylation subtype classification identifies two epi-clusters associated with distinct muscle-invasive status and patient outcome, namely, EpiC-low and EpiC-high. While the former is hypomethylated, immune-depleted, and enriched for FGFR3-mutated, the latter is hypermethylated, immune-infiltrated, and tightly associated with somatic mutations of SWI/SNF genes. Conclusions Our study delineates for the first time the key role for convergence between genetic and epigenetic alterations in shaping clinicopathological and immune upper tract urothelial carcinoma features.

Evaluation of upper tract urothelial carcinomas by contrast-enhanced ultrasound

2018 ◽  
Vol 60 (6) ◽  
pp. 496-503
Author(s):  
A.A. Painel Seguel ◽  
M.J. Martínez Pérez ◽  
T. Ripollés González ◽  
D.P. Gómez ◽  
J. Vizuete del Río ◽  
...  
Keyword(s):  
Contrast Enhanced Ultrasound ◽  
Upper Tract ◽  
Urothelial Carcinomas ◽  
Contrast Enhanced

A review of the contemporary management of upper urinary tract urothelial carcinoma

2017 ◽  
Vol 11 (1) ◽  
pp. 51-57
Author(s):  
Abhishek Reekhaye ◽  
Seshadri Sriprasad ◽  
Sanjeev Madaan
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Upper Urinary Tract ◽  
Rare Tumour ◽  
Endoscopic Techniques ◽  
Upper Tract ◽  
Urothelial Carcinomas ◽  
Urinary Tract Urothelial Carcinoma

Upper tract urothelial carcinoma (UTUC) is relatively rare and accounts for approximately 5% of all urothelial carcinomas. The estimated annual incidence of UTUC in Western countries is about two new cases per 100,000 inhabitants. The management of patients with upper tract urothelial carcinomas has changed significantly over the last decade with improved diagnostic techniques and treatment options. The gold-standard treatment used to be open radical nephroureterectomy with removal of the ipsilateral bladder cuff. The use of minimally invasive techniques for the diagnosis and management of upper urinary tract urothelial carcinoma is however expanding and has led to a paradigm shift in treatment strategies of upper tract urothelial carcinomas. In this article, we review the current diagnostic modalities and various endoscopic techniques being currently used in the management of this relatively rare tumour.

scholarly journals Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

2013 ◽  
Vol 5 (197) ◽  
pp. 197ra102-197ra102 ◽  
Author(s):  
M. L. Hoang ◽  
C.-H. Chen ◽  
V. S. Sidorenko ◽  
J. He ◽  
K. G. Dickman ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Aristolochic Acid ◽  
Acid Exposure ◽  
Mutational Signature ◽  
Whole Exome

scholarly journals Impact of the preoperative prognostic nutritional index on survival outcomes in upper tract urothelial carcinomas

2019 ◽  
Vol 8 (6) ◽  
pp. 2971-2978 ◽  
Author(s):  
Wenbin Xue ◽  
Ping Tan ◽  
Hang Xu ◽  
Lu Yang ◽  
Qiang Wei
Keyword(s):  
Prognostic Nutritional Index ◽  
Survival Outcomes ◽  
Upper Tract ◽  
Nutritional Index ◽  
Urothelial Carcinomas

Intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinomas: predictors and impact on subsequent oncological outcomes from a national multicenter study

2012 ◽  
Vol 31 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Evanguelos Xylinas ◽  
Pierre Colin ◽  
François Audenet ◽  
Véronique Phe ◽  
Luc Cormier ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Radical Nephroureterectomy ◽  
Upper Tract ◽  
Oncological Outcomes ◽  
Urothelial Carcinomas

Sex differences in upper tract urothelial carcinomas

2019 ◽  
Vol 29 (3) ◽  
pp. 256-260
Author(s):  
Nirmish Singla ◽  
Rashed A. Ghandour ◽  
Vitaly Margulis
Keyword(s):  
Sex Differences ◽  
Upper Tract ◽  
Urothelial Carcinomas

Towards the future of upper tract urothelial carcinoma surveillance: lessons learnt from bladder cancer urinary biomarkers

2019 ◽  
Vol 37 (9) ◽  
pp. 1985-1986 ◽  
Author(s):  
Andrea Gallioli ◽  
Romain Boissier ◽  
Angelo Territo ◽  
Alberto Breda
Keyword(s):  
Bladder Cancer ◽  
Urothelial Carcinoma ◽  
Urinary Biomarkers ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract ◽  
Lessons Learnt ◽  
The Future
Sign in / Sign up

Export Citation Format

Share Document