Diverging incidence trends of oral tongue cancer compared with other head and neck cancers in young adults in France

Cardiac metastasis from a primary head and neck cancer is a rare finding. Most patients with cardiac metastases have nonspecific symptoms that may vary depending on the severity and location of the lesion. Due to the infrequency of reported cases, there are no clear guidelines for the diagnosis or management of cardiac metastasis in head and neck cancer patients. In this report, we discuss the case of a patient with a primary diagnosis of oral tongue cancer who developed a cardiac metastasis that was detected antemortem.

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The promise of immunotherapy in the treatment of young adults with oral tongue cancer

Laryngoscope Investigative Otolaryngology ◽

10.1002/lio2.366 ◽

2020 ◽

Vol 5 (2) ◽

pp. 235-242 ◽

Cited By ~ 2

Author(s):

Hassan Nasser ◽

Maie A. St. John

Keyword(s):

Young Adults ◽

Tongue Cancer ◽

Oral Tongue ◽

Oral Tongue Cancer

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Oral Cavity and Pharynx Cancer Incidence Trends by Subsite in the United States: Changing Gender Patterns

Journal of Oncology ◽

10.1155/2012/649498 ◽

2012 ◽

Vol 2012 ◽

pp. 1-10 ◽

Cited By ~ 28

Author(s):

Linda Morris Brown ◽

David P. Check ◽

Susan S. Devesa

Keyword(s):

Oral Cavity ◽

Tongue Cancer ◽

The United States ◽

Sexual Practices ◽

Birth Cohorts ◽

Oral Tongue ◽

Incidence Trends ◽

Oral Tongue Cancer ◽

Cancer Rates ◽

Pharynx Cancer

Objective. To evaluate oral cavity and pharynx cancer (OCPC) patterns by gender.Methods. We used Surveillance, Epidemiology, and End Results program data for 71,446 cases diagnosed during 1975–2008 to classify OCPC by anatomic subsite as potentially HPV-related or not, with oral tongue cancer considered a separate category.Results. Total OCPC rates among men were 2–4 times those among women. Among whites, total OCPC rates rose in the younger age groups due to substantial increases in successive birth cohorts for HPV-related cancers, more rapid among men than women, and oral tongue cancers, more rapid among women than men. Among blacks, total OCPC rates declined among cohorts born since 1930 reflecting the strong downward trends for HPV-unrelated sites. Among Hispanics and Asians, HPV-unrelated cancer rates generally declined, and oral tongue cancer rates appeared to be converging among young men and women.Conclusions. Decreases in total OCPC incidence reflect reductions in smoking and alcohol drinking. Rising HPV-related cancers among white men may reflect changing sexual practices. Reasons for the increasing young oral tongue cancer rates are unknown, but the narrowing of the gender differences provides a clue.

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ASSOCIATION OF THE DEPTH OF TUMOR & LYMPHATIC METASTASIS IN ORAL TONGUE CANCER

10.36106/ijsr/5011078 ◽

2020 ◽

pp. 1-4

Author(s):

Vishram Singh Gurjar ◽

D.P. Gupta ◽

Shubhangi Gupta ◽

Nand Kishor Lohar ◽

Shailesh Kumar Jain ◽

...

Keyword(s):

Head And Neck ◽

Lymphatic Metastasis ◽

Tongue Cancer ◽

Neck Region ◽

Nodal Metastasis ◽

Positive Lymph Node ◽

Tumor Thickness ◽

Oral Tongue ◽

Neck Node ◽

Oral Tongue Cancer

Carcinoma of tongue is one of the most notorious cancer of head and neck region. It constitutes about 36.5% of all oral malignancies. Neck node status is the single most important prognostic factor in oral tongue cancers and other head and neck cancers . Another important parameter which has the greatest influence on survival is the tumor thickness especially in carcinoma tongue . In this study, we assessed the association between tumor thickness & lymphatic metastasis in oral tongue cancer. The optimal cut-off point for tumor thickness was 4mm. Total 126 cases were studied of which maximum cases were between 40-49 years of age .Cases were more prevalent in males (69.05%) than females(30.95%) . As the T-stage of cancer progressed , the incidence of nodal metastasis also progressively advanced. It was also observed that as the tumor thickness increased , the proportion of positive lymph node cases also significantly increased. There was significant positive correlation between the tumor thickness measured on MRI and histopathology (r=0.709 , p<0.001)

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Clinical features and outcomes in young adults with oral tongue cancer

American Journal of Otolaryngology ◽

10.1016/j.amjoto.2018.09.022 ◽

2019 ◽

Vol 40 (1) ◽

pp. 93-96 ◽

Cited By ~ 3

Author(s):

Courtney Miller ◽

Aryan Shay ◽

Bobby Tajudeen ◽

Neilayan Sen ◽

Mary Fidler ◽

...

Keyword(s):

Young Adults ◽

Clinical Features ◽

Tongue Cancer ◽

Oral Tongue ◽

Oral Tongue Cancer

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Improving Risk Stratification of Early Oral Tongue Cancer with TNM-Immune (TNM-I) Staging System

Cancers ◽

10.3390/cancers13133235 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3235

Author(s):

Alhadi Almangush ◽

Ibrahim O. Bello ◽

Ilkka Heikkinen ◽

Jaana Hagström ◽

Caj Haglund ◽

...

Keyword(s):

Overall Survival ◽

Tongue Cancer ◽

Early Stage ◽

Disease Free Survival ◽

Tumor Infiltrating Lymphocytes ◽

Staging System ◽

Oral Tongue ◽

Oral Tongue Cancer ◽

Important Player ◽

Infiltrating Lymphocytes

Although patients with early-stage oral tongue squamous cell carcinoma (OTSCC) show better survival than those with advanced disease, there is still a number of early-stage cases who will suffer from recurrence, cancer-related mortality and worse overall survival. Incorporation of an immune descriptive factor in the staging system can aid in improving risk assessment of early OTSCC. A total of 290 cases of early-stage OTSCC re-classified according to the American Joint Committee on Cancer (AJCC 8) staging were included in this study. Scores of tumor-infiltrating lymphocytes (TILs) were divided as low or high and incorporated in TNM AJCC 8 to form our proposed TNM-Immune system. Using AJCC 8, there were no significant differences in survival between T1 and T2 tumors (p > 0.05). Our proposed TNM-Immune staging system allowed for significant discrimination in risk between tumors of T1N0M0-Immune vs. T2N0M0-Immune. The latter associated with a worse overall survival with hazard ratio (HR) of 2.87 (95% CI 1.92–4.28; p < 0.001); HR of 2.41 (95% CI 1.26–4.60; p = 0.008) for disease-specific survival; and HR of 1.97 (95% CI 1.13–3.43; p = 0.017) for disease-free survival. The TNM-Immune staging system showed a powerful ability to identify cases with worse survival. The immune response is an important player which can be assessed by evaluating TILs, and it can be implemented in the staging criteria of early OTSCC. TNM-Immune staging forms a step towards a more personalized classification of early OTSCC.

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