scholarly journals Selenium and cancer risk: wide‐angled Mendelian randomization analysis

2021 ◽  
Author(s):  
Shuai Yuan ◽  
Amy M. Mason ◽  
Paul Carter ◽  
Mathew Vithayathil ◽  
Siddhartha Kar ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Mendelian Randomization ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis

2018 ◽  
Vol 110 (9) ◽  
pp. 1035-1038 ◽  
Author(s):  
James Yarmolinsky ◽  
Carolina Bonilla ◽  
Philip C Haycock ◽  
Ryan J Q Langdon ◽  
Luca A Lotta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals 237P Breast cancer risk in patients with polycystic ovary syndrome: A Mendelian randomization analysis

2020 ◽  
Vol 31 ◽  
pp. S335
Author(s):  
X. Wu ◽  
Y. Wen ◽  
H. Peng ◽  
C. Li ◽  
H. Liang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Polycystic Ovary Syndrome ◽  
Mendelian Randomization ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: A Mendelian randomization analysis

PLoS Medicine ◽  
2019 ◽  
Vol 16 (8) ◽  
pp. e1002893 ◽  
Author(s):  
James Yarmolinsky ◽  
Caroline L. Relton ◽  
Artitaya Lophatananon ◽  
Kenneth Muir ◽  
Usha Menon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Cancer Risk ◽  
Epithelial Ovarian Cancer ◽  
Mendelian Randomization ◽  
Ovarian Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

Abstract 1270: Vitamin E related genetic variants and prostate cancer risk: A Mendelian randomization analysis

2017 ◽  
Author(s):  
Tracy M. Layne ◽  
Shakira M. Nelson ◽  
Stephanie J. Weinstein ◽  
Eric Karlins ◽  
Stephen J. Chanock ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Mendelian randomization study of spermine oxidase and cancer risk

2020 ◽  
Author(s):  
João Fadista ◽  
Victor Yakimov ◽  
Urmo Võsa ◽  
Christine S. Hansen ◽  
Silva Kasela ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Mendelian Randomization ◽  
Summary Statistics ◽  
Spermine Oxidase ◽  
Mendelian Randomization Analysis ◽  
Risk Of Cancer ◽  
Randomization Analysis

ABSTRACTImportanceSpermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of induced reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention.ObjectiveTo test the causality of SMOX levels with cancer risk using a Mendelian randomization analysis.Design, Setting, and ParticipantsWe performed a GWAS of spermidine/spermine ratio, from blood of 534 infants, to identify genetic variants associated with regulation of SMOX activity. In two additional data sets of 262 newborns and 508 adults, we quantified SMOX gene expression using RNA-sequencing and performed expression and methylation QTL lookups. We then did a Mendelian randomization analysis by testing the association between the SMOX genetic instrument and various cancer types using GWAS summary statistics.Main Outcomes and MeasuresNeuroblastoma, gastric, lung, breast, prostate, and colorectal cancers.ResultsThe GWAS of spermidine/spermine ratio identified a genome-wide significant locus (P=1.34×10−49) explaining 32% of the variance. The lead SNP rs1741315 was also associated with SMOX gene expression in newborns (P=8.48×10−28) and adults (P=2.748×10−8) explaining 37% and 6% of the variance, respectively. rs1741315 was not associated with neuroblastoma (OR=0.95; 95% CI:0.88, 1.03; P=0.18), gastric (OR=0.99; 95% CI:0.95, 1.03; P=0.54), lung (OR=0.97; 95% CI:0.94, 1.00; P=0.08), breast (OR=0.99; 95% CI:0.96, 1.02; P=0.47), prostate (OR=0.98; 95% CI:0.96, 1.00; P=0.05) nor colorectal cancer (OR=1.03; 95% CI:0.99, 1.07; P=0.10). A PheWAS of rs1741315 did not reveal any associations with risk factors of the cancers tested.Conclusions and RelevanceGenetic variation in the SMOX gene was strongly associated with SMOX activity in newborns, and less strongly in adults. Genetic down-regulation of SMOX was not significantly associated with lower odds of neuroblastoma, gastric, lung, breast, prostate and colorectal cancer. Further studies are needed to understand the effect of SMOX inhibition in relation to cancer risk.ARTICLE SUMMARYQuestionIs SMOX causally associated with risk of cancer?FindingsIn this Mendelian randomization study, genetically lower levels of SMOX were not associated with decreased risk of neuroblastoma, gastric, lung, breast, prostate and colorectal cancer.MeaningThese findings do not support a causal association between SMOX activity and risk of cancer, suggesting that ongoing efforts to identify SMOX inhibitors for chemoprevention may not be successful.STRENGHTS AND LIMITATIONS-Previous studies which examined SMOX activity and cancer risk were susceptible to recall bias, confounding and reverse causation, none of which are concerns of this Mendelian randomization study.-Our genetic instrument explained a sizeable proportion of the variance of SMOX activity-We used summary statistics from the largest meta-analyses of primary cancer GWAS to date.-Elevated SMOX levels in cancer could also be due to environmental factors not captured by genetics.-Our genetic instrument was developed based on normal range SMOX activity data, thus additional genetic variants might play a role in aberrant expression of this enzyme.

scholarly journals Association between serum iron status and primary liver cancer risk: a Mendelian randomization analysis

2021 ◽  
Vol 0 (0) ◽  
pp. 1533-1533
Author(s):  
Tao Tian ◽  
Feng Xiao ◽  
Hongdong Li ◽  
Dongyang Ding ◽  
Wei Dong ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Risk ◽  
Serum Iron ◽  
Mendelian Randomization ◽  
Iron Status ◽  
Primary Liver Cancer ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Letter regarding article, “Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis”

2019 ◽  
Vol 48 (3) ◽  
pp. 1014-1015 ◽  
Author(s):  
Vanessa Y Tan ◽  
James Yarmolinsky ◽  
Debbie A Lawlor ◽  
Nicholas J Timpson
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals P42.08 Association Between the Age at First-Live Birth and Lung Cancer Risk: Meta-Analysis and Mendelian Randomization Analysis

2021 ◽  
Vol 16 (3) ◽  
pp. S480-S481
Author(s):  
Y. Ao ◽  
Y. Li ◽  
Y. Wen ◽  
H. Liang ◽  
W. Liang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Live Birth ◽  
Lung Cancer Risk ◽  
Mendelian Randomization ◽  
Meta Analysis ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis
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